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Rosuvastatin-d3

Stable Isotope

Rosuvastatin-d3 is a stable isotope-labeled form of Rosuvastatin, a potent competitive inhibitor of HMG-CoA reductase, demonstrating an IC50 of 11 nM. This compound also significantly inhibits the human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM. Research applications include studying cholesterol biosynthesis, cardiac repolarization, and the effects of statins on action potential durations and corrected QT intervals in cardiac tissues.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1133429-16-9
Applications	Stable Isotope
Formula	C₂₂H₂₅D₃FN₃O₆S
Molecular Weight	484.56
Synonyms	ZD 4522 d3
SMILES	FC(C=C1)=CC=C1C2=NC(N(C([2H])([2H])[2H])S(=O)(C)=O)=NC(C(C)C)=C2/C=C/[C@@H](O)C[C@@H](O)CC(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.