Fig. 1 · Structure
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Ivacaftor-d19
Stable Isotope
Ivacaftor-d19 is a stable isotope variant of the established CFTR modulator, Ivacaftor. It demonstrates effective potentiation of the CFTR protein, exhibiting an EC50 value of 255 nM in G551D/F508del human bronchial epithelial cells. This deuterated analog serves as a valuable tool for cystic fibrosis research, enabling detailed studies of CFTR function and pharmacological modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1413431-22-7 |
| Applications | Stable Isotope |
| Formula | C24H9D19N2O3 |
| Molecular Weight | 411.61 |
| Synonyms | VX-770-d19 |
| SMILES | O=C(C1=CNC2=C(C=CC=C2)C1=O)NC3=CC(O)=C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])C([2H])=C3C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.