Delmopinol hydrochloride

Delmopinol is a surface-active cationic compound that functions as an anti-plaque and anti-gingivitis agent. It interacts with the acquired pellicle—a thin salivary film composed of proteins and glycoproteins that coats the teeth and gums—and forms a protective barrier over oral surfaces. This barrier inhibits microbial adhesion and biofilm formation, thereby preventing plaque accumulation and gingival inflammation.

Although Delmopinol does not possess direct bactericidal activity, its ability to interfere with bacterial colonization makes it effective in maintaining oral hygiene. It has been approved by the U.S. FDA under the trade name **Decapinol** for the treatment of gingivitis and the prevention of periodontitis.