Catalog No.
Product Name
Application
Product Information
Citations
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ASADH Inhibitor
Naphthalene-2,3-Dicarboxaldehyde functions as a potent inhibitor of Aspergillus nidulans succinate semialdehyde dehydrogenase (ASADH), with a reported inhibition constant (Ki) of 45 μM. Its biological activity extends to inhibiting the growth of Candida albicans strain CAF2-1, exhibiting an IC50 of 58.2 μM and a minimum inhibitory concentration (MIC) of 12 μg/mL. This compound is valuable for research applications focused on antifungal mechanisms and metabolic pathway studies involving ASADH. -
Antimalarial Agent
Halofantrine hydrochloride is an antimalarial agent that primarily targets human ERG channels, inhibiting the delayed rectifier potassium current. This compound demonstrates significant antimalarial activity against Plasmodium strains in both in vitro and animal models, while also exhibiting antifungal properties by inhibiting the Cap1-dependent oxidative stress response in Candida albicans. Its effectiveness extends to enhancing the antifungal activity of agents inducing oxidative damage and is particularly relevant for research on invasive candidiasis, falciparum malaria, and vivax malaria. -
Polyene Macrolide
Lagosin is a polyene macrolide antibiotic that targets fungal cell membranes. It exhibits broad-spectrum antifungal activity, making it effective against various fungal pathogens. Due to its unique mechanism of action, Lagosin remains resistant to many common antifungal resistance mechanisms, making it a valuable reagent for research in mycology and antifungal drug development. -
Antifungal Agent
Nikkomycin Z is a nucleoside peptide that functions as an orally active antifungal agent. It acts as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine, thereby inhibiting chitin synthesis. This mechanism contributes to its notable antifungal activity, making Nikkomycin Z a valuable tool for research in fungal infections and chitin metabolism. -
Glucanase
Endo-1,3-β-glucanase is an endoenzyme that specifically targets β-1,3-glycosidic bonds within glucan chains. Its catalytic activity hydrolyzes polysaccharides into oligosaccharides, making it valuable in research focused on fungal infections, notably Candida spp. This enzyme is particularly applicable in studies related to recurrent Candida vaginitis, where it can aid in understanding the pathogen's cell wall composition and potential therapeutic strategies. -
Antibacterial Agent
Germacrene D is an antibacterial agent derived from Solidago canadensis. It exhibits significant antibacterial and antifungal activities, demonstrating potential as an adjuvant in enhancing the efficacy of aminoglycosides and azoles. This compound is valuable for research applications focused on combating microbial infections and exploring synergistic effects in antimicrobial therapies. -
β-1,3-glucan Inhibitor
Ibrexafungerp citrate is a potent β-1,3-glucan synthesis inhibitor with promising antifungal properties. This compound demonstrates efficacy against a range of fungal infections, specifically targeting Candida and Aspergillus species. Ibrexafungerp citrate is currently under investigation for its therapeutic potential in the treatment of these serious infections. -
Antifungal Agent
4-Isopropylbenzoic acid is an aromatic monoterpenoid known for its antifungal properties. Isolated from the stem bark of Bridelia retusa, this compound demonstrates significant activity against various fungal strains. Additionally, it acts as a reversible and uncompetitive inhibitor of mushroom tyrosinase, making it relevant in studies related to enzymatic inhibition and fungal pathogen research. -
Fungal Inhibitor
Paclobutrazol is a triazole-based compound that functions primarily as a fungal inhibitor by disrupting the biosynthesis of gibberellins. Its antifungal properties make it useful in investigating plant-pathogen interactions and enhancing plant resilience. Additionally, Paclobutrazol can suppress abscisic acid synthesis and promote chilling tolerance in various plant species, supporting research into plant stress responses and growth regulation. -
Antibacterial Agent
GI261520A functions as an antibacterial agent primarily by inhibiting the PhoQ phosphorylation pathway. This compound exhibits a dose-dependent suppression of PhoP/PhoQ activity and demonstrates an IC50 value of 3.2 μM in inhibiting pagC reporter expression levels. Additionally, GI261520A effectively reduces PhoQc autokinase activity by 80%, allowing it to penetrate eukaryotic cell membranes and target intravacuolar Salmonella, thereby preventing intramacrophage proliferation. It serves as a valuable tool for research into antibacterial mechanisms and intracellular bacterial behavior. -
HER2 Ligand
Camelliaside A is a phytochemical that functions as a HER2 ligand. It plays a significant role in breast cancer-related research, contributing to the understanding of HER2 signaling pathways. Notably, Camelliaside A does not exhibit antifungal activity against the pathogen Rhizoctonia solani, demonstrating its specificity in targeting HER2 without adversely affecting mycelial growth. -
Anticancer/antifungal Agent
Echinoside A is a saponin that primarily targets Topoisomerase II alpha (Top2α), inhibiting its catalytic activity and reducing its noncovalent binding to DNA. This compound activates Caspase-3 and induces PARP cleavage, thereby promoting apoptosis. Echinoside A exhibits significant anticancer properties against various cancers, including prostate cancer, hepatocellular carcinoma, and S-180 sarcoma. Additionally, it displays antifungal activity across a spectrum of fungi, with a minimum inhibitory concentration ranging from 3.12 to 50.0 μg/mL, demonstrating particularly strong effects against Aspergillus and Penicillium species. -
Histone Acetyltransferase Inhibitor
Rtt109 inhibitor 1 is a potent inhibitor of the histone acetyltransferase Rtt109, functioning through a tight-binding, uncompetitive mechanism. This compound demonstrates significant antifungal activity by specifically targeting acetylation at the H3K56 site. Rtt109 inhibitor 1 is suitable for research applications focused on histone modifications and their roles in fungal pathogenesis. -
RNA Modifying Substance
N4-Acetylcytidine is an RNA-modifying nucleoside metabolite produced during tRNA degradation, primarily via N-acetyltransferase 10 and additional enzymes. This compound has been shown to enhance NLRP3 inflammasome activation through the upregulation and release of HMGB1. N4-Acetylcytidine plays a crucial role in modifying the stability and translation efficiency of mRNA, tRNA, and rRNA, particularly in relation to enterovirus 71 RNA. Its applications extend to research in cancer, neuroinflammatory diseases, viral infections, and obesity. -
HDM Inhibitor
HDM-IN-1 is a potent inhibitor of histone demethylases (HDM), specifically targeting H3K27me3 methylation in fungal pathogens such as Cryptococcus neoformans and Candida auris, with IC50 values of 134 nM and 12 nM, respectively. This compound demonstrates significant antifungal activity, achieving MIC80 values between 0.5-2 μg/mL by disrupting biofilm and capsule formation. In vivo studies in an ICR mouse model further confirm its efficacy as an antifungal agent. HDM-IN-1 is a valuable tool for research on histone modifications and their implications in fungal virulence and drug resistance. -
Bacterial Inhibitor
Enoxacin is a fluoroquinolone antibacterial that primarily targets bacterial DNA gyrase and topoisomerase IV, with reported IC50 values of 126 µg/ml and 26.5 µg/ml, respectively. It exhibits strong inhibitory activity against both gram-positive and gram-negative bacteria. Additionally, Enoxacin acts as a miRNA processing activator, facilitating siRNA-mediated mRNA degradation and promoting the biogenesis of endogenous miRNAs. Notably, Enoxacin serves as a cancer-specific growth inhibitor through the enhancement of TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing, making it valuable for research in bacterial inhibition and cancer biology. -
Parasite Inhibitor
Dihydroartemisinic acid, a biosynthetic precursor to the antimalarial compound Artemisinin, functions primarily as a parasite inhibitor. This compound demonstrates potent activity against malaria-causing Plasmodium species, making it valuable for research in malaria treatment and drug development. Its role in synthesizing Artemisinin positions it as an important reagent for studies focusing on antimalarial therapies. -
Anti-HIV Agent
Oleanonic acid, a triterpene, primarily targets anti-HIV activity. It exhibits notable anti-inflammatory properties and can ameliorate conditions associated with oxidative stress, autophagy dysfunction, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress, particularly induced by Amyloid-β in vitro. Additionally, oleanonic acid has been demonstrated to reduce myocardial hypertrophy in rat models in vivo, highlighting its potential for therapeutic applications in cardiovascular and neurodegenerative research. -
Antifungal Agent
Fluconazole is a triazole antifungal agent that primarily targets fungal infections by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. It exhibits potent activity against a wide spectrum of fungi, particularly Candida albicans and Candida kefyr, with IC99 values ranging from 0.20 μg/mL to 0.39 μg/mL. Fluconazole is widely utilized in research to study fungal pathogenesis and develop therapeutic strategies against fungal infections. -
Quinolone Antibiotic
Lomefloxacin hydrochloride is a difluoroquinolone antibiotic that primarily targets bacterial topoisomerase II, inhibiting DNA supercoiling and replication. It exhibits broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria and induces reactive oxygen species (ROS) production, leading to apoptosis. Additionally, Lomefloxacin hydrochloride demonstrates anticancer effects, particularly against melanoma, making it a valuable reagent for studying systemic bacterial infections and skin malignancies. -
Antifungal Agent
Miconazole is an imidazole antifungal agent that acts through the inhibition of ergosterol synthesis, disrupting fungal cell membrane integrity. In addition to its antifungal properties, Miconazole exhibits antibacterial effects, making it a versatile compound in microbiological studies. This reagent is commonly utilized in research focusing on antifungal therapies and mechanisms of microbial resistance. -
Antifungal Agent
Miconazole nitrate is an imidazole antifungal agent that exhibits its primary mechanism through the inhibition of ergosterol synthesis, leading to compromised fungal membrane integrity. This compound demonstrates significant antifungal activity against a broad spectrum of fungi, making it valuable for research in antifungal drug development and therapeutic applications. Additionally, Miconazole nitrate possesses antibacterial properties, contributing to its utility in studies related to infections and microbial resistance. -
Antibiotic
Novobiocin sodium is a potent antibiotic that primarily targets DNA gyrase, exhibiting significant inhibitory action in various bacterial strains. Additionally, it acts as an antagonist of heat shock protein 90 (Hsp90), expanding its potential applicability in therapeutic research. Novobiocin sodium is particularly valuable for studies on beta-lactam-resistant pneumococcal infections and demonstrates anti-orthopoxvirus activity, highlighting its relevance in infectious disease research. -
Bacterial Inhibitor
Roxithromycin is a semi-synthetic macrolide antibiotic that exerts its antibacterial effects by inhibiting protein biosynthesis at the elongation step through binding to the 50S subunit of the bacterial ribosome. This compound demonstrates broad biological activity, including antimicrobial, antiproliferative, and anti-inflammatory properties. Additionally, Roxithromycin has been shown to inhibit tumor vasculature and alleviate lung injury, making it a valuable reagent for research applications in infectious disease, cancer therapy, and respiratory health. -
Nucleoside Reverse Transcriptase Inhibitor
Stavudine is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that selectively targets HIV-1 and HIV-2. In addition to its antiviral properties, Stavudine inhibits mitochondrial DNA replication and has been shown to reduce NLRP3 inflammasome activation while modulating Amyloid-β autophagy. Furthermore, Stavudine is associated with the induction of apoptosis, making it a valuable tool for research in HIV treatment and cellular apoptosis mechanisms. -
Antimicrobial Agent
Terbinafine is a potent antimicrobial agent that primarily acts as a non-competitive inhibitor of squalene epoxidase, exhibiting a Ki of 30 nM against Candida species. This compound demonstrates significant antifungal activity and also shows antibacterial effects against select Gram-positive and Gram-negative bacteria. Additionally, Terbinafine features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) for versatile chemical applications in research. -
Antifungal Agent
Oxiconazole nitrate is a broad-spectrum antifungal agent targeting various fungal pathogens, including Candida, Aspergillus, and Trichophyton. In addition to its antifungal properties, it acts as a potent activator of CYP3A4 transactivation, with the potential for competitive antagonism by Rifampicin. Furthermore, Oxiconazole nitrate exhibits inhibitory effects against colorectal cancer through mechanisms involving peroxiredoxin-2 (PRDX2)-mediated autophagy arrest, making it valuable for research in both antifungal therapy and cancer biology. -
Squalene Epoxidase Inhibitor
Liranaftate is a potent squalene epoxidase inhibitor exhibiting anti-fungal properties. It is primarily utilized in research focusing on dermatophyte infections. Additionally, Liranaftate has been shown to suppress the fungal element-mediated production of interleukin-8 (IL-8) and modulate inflammatory responses, making it valuable for studies involving inflammatory pathways in fungal infections. -
Antibiotic
Bifonazole is an imidazole antifungal agent that primarily targets fungal cell membranes. It exhibits broad-spectrum antibacterial and antifungal activity, making it effective against various dermatophytes and yeast infections. Bifonazole is utilized in research settings to study antifungal mechanisms and evaluate new therapeutic strategies for fungal infections. -
Antifungal Agent
Gartanin is a natural xanthone derived from mangosteen, primarily functioning as an antifungal agent. It exhibits significant antioxidant and anti-inflammatory properties, alongside neuroprotective and antineoplastic effects. Gartanin has been shown to induce cell cycle arrest and autophagy, while also inhibiting migration in human glioma cells, making it a valuable compound for research in cancer and fungal pathologies. -
Fungal Inhibitor
Pseudolaric Acid C is a bioactive diterpenoid derived from the root bark of Pseudolarix amabilis, primarily acting as a fungal inhibitor. It exhibits significant antifungal activity, making it a valuable tool for research focused on fungal pathogenesis and the development of antifungal therapies. Its ability to disrupt fungal growth positions it as an important compound in the study of mycology and related fields. -
Fungal Inhibitor
5-Hydroxymethylfurfural is a furan derivative that serves as a potent fungal inhibitor. It exhibits anti-yeast activity by suppressing growth and fermentation under stress conditions, making it valuable for studies related to microbial resistance and fermentation processes. This compound is utilized in research focused on food preservation and biotechnological applications. -
Antibacterial/Anticancer Agent
Usnic acid is a secondary metabolite derived from lichens, exhibiting significant antibacterial and anticancer properties. It functions primarily by inhibiting DNA and RNA synthesis, leading to cell cycle arrest and apoptosis in various cancer cell lines. Additionally, usnic acid suppresses RANKL-mediated osteoclast formation and function through downregulation of NFATc1. Its antioxidant and anti-inflammatory effects are attributed to the inhibition of lipid peroxidation and myeloperoxidase activity, making it a valuable reagent for diverse biological research applications. -
Bactericidal Agent
Terpinen-4-ol, a naturally occurring monoterpene, acts primarily as a bactericidal agent. This compound exhibits significant antifungal, anti-inflammatory, and antitumor activities, making it a valuable tool for diverse research applications, especially in the study of microbial resistance and inflammation. Its multiple biological effects also support investigations into potential therapeutic uses in various diseases. -
Bicyclic Sesquiterpene
Caryophyllene oxide is a bicyclic sesquiterpene known for its anticancer properties, particularly its ability to induce apoptosis in PC-3 prostate cancer cells. This compound also exhibits significant analgesic and anti-inflammatory activities, making it valuable for pain management research. Additionally, caryophyllene oxide demonstrates a range of biological activities, including insecticidal, antioxidant, antimicrobial, antifungal, and antiparasitic effects, supporting its utility in various pharmacological studies and natural product research. -
Anti-Fungal Agent
Hypocrellin B is a photosensitizer with significant apoptotic properties, primarily used in photodynamic therapy for cancer treatment. Isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, it exhibits both antimicrobial and antileishmanial activities. This compound is valuable in research exploring its efficacy against various fungal infections and its potential therapeutic applications in oncology. -
Antifungal Agent
4-Methylcinnamic acid is a cinnamic acid derivative primarily known for its antifungal properties. This compound demonstrates the capability to enhance the efficacy of traditional antifungal agents by lowering their minimum inhibitory concentrations, particularly in the presence of glutathione reductase mutants. Its mechanism includes disrupting fungal cell walls, making it a promising candidate for research into combating drug-resistant fungi. 4-Methylcinnamic acid shows potential applications in the development of more effective antifungal therapies. -
Antifungal Agent
Vincetoxicoside B is an antifungal agent that exhibits potent activity against various fungal pathogens. This compound can be utilized in research focused on fungal infections and the development of new therapeutic strategies. Its mechanism of action and efficacy make it a valuable tool in the study of antifungal mechanisms and resistance. -
Fungal Inhibitor
Hecogenin is a steroid saponin derived from Agave sisalana, known for its selective inhibition of human UDP-glucuronosyltransferases. It exhibits a diverse range of biological activities, particularly as a potent antifungal agent, while also demonstrating anti-inflammatory and gastroprotective properties. Hecogenin is of interest in pharmacological research for its potential therapeutic applications in treating fungal infections and inflammatory conditions. -
Antioxidant/Antibacterial/Anticancer Agent
Carvacrol is a monoterpenic phenol that functions as an antioxidant, antibacterial, and anticancer agent. It has demonstrated the ability to cause cell cycle arrest in the G0/G1 phase, downregulate Notch-1 and Jagged-1, and induce apoptosis in cancerous cells. Carvacrol is frequently utilized in research to investigate its therapeutic effects in various biological systems, alongside its applications in food preservation and cosmetic formulations due to its flavoring and fragrance properties. -
Cytochrome P450 1A1 Inactivator
Rhapontigenin is a potent and selective inactivator of cytochrome P450 1A1, demonstrating an IC50 of 400 nM. This natural analog of resveratrol exhibits significant anticancer, antioxidant, antifungal, and antibacterial properties. Due to its 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively, Rhapontigenin is a valuable tool for research focused on cancer biology and drug metabolism. -
Bacterial Inhibitor
Benzoic acid is an aromatic carboxylic acid that functions as a bacterial inhibitor. It demonstrates significant antimicrobial activity by inhibiting the growth of bacteria and fungi, making it an effective preservative. Benzoic acid is widely utilized in food, beverages, cosmetics, and various research applications to study microbial growth inhibition and preservation techniques. -
Antifungal Agent
Xanthoxylin, an antifungal agent derived from Zanthoxylum simulans, exhibits notable antifungal and antioxidant properties. It demonstrates minimum inhibitory concentrations (MIC) of 50 µg/mL against Toxoplasma neonatorum and 75 µg/mL against Aspergillus fumigatus. This compound is valuable for investigating antifungal therapies and exploring potential applications in the context of anti-epileptic diseases. -
Antibacterial/Antifungal agent
Dehydroacetic acid is a pyrone derivative known for its antibacterial and antifungal properties. This compound exhibits significant phytotoxic activity, making it a valuable agent in various applications such as preservation in cosmetics, food, and beverages. Additionally, dehydroacetic acid serves as a precursor in the synthesis of various heterocycles and cycloaddition products, providing utility in chemical research and development. -
Antibiotic
Phenothiazine is an antibiotic that exhibits broad-spectrum biological activity, including insecticidal, fungicidal, antibacterial, and anthelmintic effects. Additionally, it is instrumental in research related to neurological diseases, offering insights into potential therapeutic mechanisms. This compound serves as a valuable tool for scientists studying microbial resistance and the treatment of parasitic infections. -
Antifungal Agent
Sertaconazole nitrate is a broad-spectrum topical antifungal agent that primarily targets fungal infections. In addition to its antifungal properties, it exhibits anti-inflammatory activity through the activation of the p38-COX-2-PGE2 pathway. Sertaconazole nitrate also acts as a microtubule inhibitor, demonstrating antiproliferative effects, as well as the ability to induce apoptosis and autophagy. Furthermore, it can inhibit cell migration, making it valuable for various research applications in mycology and cellular biology. -
Antifungal Agent
Sulconazole mononitrate is an imidazole derivative that acts as a broad-spectrum antifungal agent. It exhibits significant efficacy against various fungal infections, making it useful for research related to dermatomycoses, pityriasis versicolor, and cutaneous candidiasis. This compound can facilitate studies aimed at understanding the mechanisms of fungal resistance and the development of effective treatment options. -
Antibiotic
Sulfacetamide sodium is a sulfonamide antibiotic targeting bacterial infections, primarily utilized in ocular research. It exhibits both antibacterial and antifungal activity, making it an important reagent for studying and treating various infections. Applications include investigation of microbial resistance and the efficacy of topical treatments against ocular pathogens. -
Bacterial Inhibitor
Tilmicosin is a macrolide antibiotic and calcium channel antagonist that targets the bacterial ribosome's 50S subunit, effectively inhibiting protein synthesis. It possesses significant antimicrobial activity and is primarily utilized in treating respiratory diseases in livestock, including cattle, sheep, and pigs. Additionally, Tilmicosin exhibits immunomodulatory and anti-inflammatory properties, making it a valuable reagent in veterinary medicine research. -
Antimicrobial Agent
Mafenide Acetate is a potent sulfonamide antimicrobial agent primarily targeting bacterial infections. It exhibits significant antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, as well as antifungal activity against filamentous fungi, including Lichtheimia and Aspergillus flavus. This compound is valuable in research applications related to skin grafts on burn wounds, post-traumatic invasive fungal infections, and the treatment of bacterially contaminated wounds.
