Catalog No.
Product Name
Application
Product Information
Citations
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Antibiotic Agent
Trovafloxacin is a broad-spectrum quinolone antibiotic that primarily targets DNA gyrase and topoisomerase IV, exhibiting potent activity against Gram-positive, Gram-negative, and anaerobic bacteria. In addition to its antibacterial effects, Trovafloxacin is a selective inhibitor of the pannexin 1 channel (PANX1) with an IC50 of 4 μM, effectively modulating PANX1 inward current. Furthermore, Trovafloxacin influences cellular processes by inducing dysregulated fragmentation of apoptotic cells through PANX1 inhibition. This dual activity positions Trovafloxacin as a valuable reagent for research in microbiology and cell biology. -
Biosurfactant
Surfactin is a cyclic lipopeptide biosurfactant exhibiting strong ionophoric activity by modulating the transport of mono- and divalent cations, such as calcium, across lipid bilayer membranes. This compound demonstrates significant antimicrobial properties, including antibacterial, antifungal, antimycoplasma, and hemolytic effects. Additionally, Surfactin possesses antiviral activity against various enveloped viruses, making it a valuable reagent for studies in microbiology, virology, and cell membrane research. -
Antibiotic
Cefoxitin is a cephalosporin-class antibiotic that exhibits strong stability against β-Lactamase. It demonstrates a broad spectrum of antibacterial activity, effective against both Gram-negative and Gram-positive bacteria. This compound is widely utilized in microbiological research and clinical studies focusing on antibiotic resistance and infection treatment. -
Antibiotic Agent
Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, demonstrating potent activity against Gram-positive, Gram-negative, and anaerobic pathogens. Additionally, it serves as a selective and orally active inhibitor of the pannexin 1 channel (PANX1), with an IC50 of 4 μM for PANX1 inward current. Unlike other channels, Trovafloxacin mesylate does not affect connexin 43 gap junctions or PANX2, leading to potential therapeutic applications in the regulation of apoptosis by disrupting normal fragmentation of apoptotic cells through PANX1 inhibition. -
Bacterial Inhibitor
Gastric mucin is a glycoprotein that acts as a bacterial inhibitor, particularly effective against Helicobacter pylori infection. It exhibits natural antibiotic properties and scavenges hydroxyl radicals, contributing to its protective role in the gastrointestinal tract. Gastric mucin plays a critical role in safeguarding against acid, proteases, and pathogenic microorganisms, while also providing defense against mechanical trauma. This functionality makes it a valuable reagent for research focused on gastrointestinal health and microbiome interactions. -
Antibiotic
G-418 is an aminoglycoside antibiotic that inhibits protein synthesis by binding to the ribosomal subunits, affecting both eukaryotic and prokaryotic cells. Its potent antibacterial properties make it a valuable tool in research applications such as the selection and maintenance of genetically modified cells, allowing for the study of gene function and expression. G-418 is widely utilized in molecular biology and cell culture workflows. -
β-lactam Antibiotic
Piperacillin is a semisynthetic broad-spectrum β-lactam antibiotic that exerts bactericidal activity against a range of Gram-negative bacteria and select Gram-positive strains by targeting penicillin-binding proteins. This compound is frequently utilized in combination with the β-lactamase inhibitor Tazobactam to enhance its efficacy in clinical applications, particularly for treating infections caused by resistant bacteria. Its extensive antimicrobial profile makes it valuable for research in infectious disease and antibiotic resistance. -
Beta-lactamase Inhibitor
Avibactam sodium hydrate is a reversible non-β-lactam β-lactamase inhibitor that specifically targets β-lactamase enzymes TEM-1 and CTX-M-15, demonstrating IC50 values of 8 nM and 5 nM, respectively. This compound is crucial for enhancing the efficacy of β-lactam antibiotics against resistant bacterial strains. Its use in research applications includes investigations into antibiotic resistance mechanisms and the development of combination therapies to overcome β-lactamase-mediated resistance. -
Cephalosporin Antibiotic
Cefazolin is a first-generation cephalosporin antibiotic that targets bacterial cell wall synthesis, inhibiting bacterial growth. It exhibits significant antibacterial activity against various gram-positive and some gram-negative bacteria, making it useful in research on bacterial infections. Additionally, Cefazolin has demonstrated anti-inflammatory properties, indicating potential applications in studies related to post-operative cognitive dysfunction (POCD). -
Bacterial Inhibitor
Mecillinam, a β-lactam antibiotic, primarily targets bacterial cell wall synthesis by inhibiting penicillin-binding proteins in gram-negative organisms. It demonstrates a broad spectrum of antibacterial activity, making it valuable in studying bacterial infections and resistance mechanisms. Researchers often utilize Mecillinam for its effectiveness against various pathogenic strains, aiding in the development of therapeutic strategies and understanding bacterial physiology. -
Bacteriostatic Antibiotic
Fusidic acid is a bacteriostatic antibiotic derived from the fungus Fusidium coccineum, classified as a steroid. Its primary mechanism of action involves the inhibition of the release of translation elongation factor G (EF-G) from the ribosome, thereby suppressing bacterial growth. This compound is of particular interest in research focused on anticancer and anti-infective applications. -
Antibacterial Agent
Zosurabalpin is a polypeptide antibiotic that targets the LPS transporter complex (LptB2FGC), effectively inhibiting the transport of lipopolysaccharides (LPS). This mechanism leads to the accumulation of endotoxins within cells, demonstrating significant antibacterial activity against Carbapenem-resistant Acinetobacter baumannii (CRAB). Zosurabalpin serves as a valuable tool for research in antibiotic resistance and bacterial infection mechanisms. -
Antibiotic
Pleuromutilin is a potent antibiotic that exerts its effects by inhibiting bacterial protein synthesis. This compound is effective against a variety of Gram-positive bacteria, making it a valuable tool in the study and treatment of antibiotic-resistant infections. Its specific mechanism of action targets the peptidyl transferase center of the ribosome, thereby disrupting essential bacterial cellular processes. Research applications include studies in microbiology, pharmacology, and infectious disease therapeutics. -
Antibiotic
Gramicidin S is a cationic cyclic peptide antibiotic that primarily targets bacterial cell membranes. It exhibits potent antibacterial activity by disrupting membrane integrity and inhibiting critical membrane protein functions, leading to cell death. The compound inserts into the phospholipid bilayer, specifically binding to negatively charged lipids, which interferes with cell division and wall synthesis. Additionally, Gramicidin S has been shown to inhibit ion channels, with IC50 values of 41 μM for Na+/K+-ATPase, 24 μM for tobacco leaf plasma membrane Mg2+/K+-ATPase, and 3 μM for rat heart plasma membrane Ca2+-ATPase, making it a valuable tool for research in microbiology and cell biology. -
Antibiotic
Lolamicin is an orally effective antibiotic that specifically targets the Gram-negative bacterial lipoprotein transport system, particularly the LolCDE complex. By competitively binding to lipoprotein binding sites, it inhibits the transmembrane transport of outer membrane lipoproteins, compromising the integrity of the bacterial outer membrane and resulting in cell death. Lolamicin demonstrates significant bactericidal and antibacterial activity against multidrug-resistant Enterobacteriaceae pathogens, including Escherichia coli and Klebsiella pneumoniae. This reagent is valuable for studying infections such as acute pneumonia and sepsis caused by Gram-negative bacteria. -
Bacterial Inhibitor
Cecropin A is a linear antimicrobial polypeptide composed of 37 residues that exhibits potent antibacterial activity. Additionally, it demonstrates anticancer and anti-inflammatory properties, making it a valuable tool for research in infectious diseases, cancer therapy, and inflammatory response studies. Its ability to disrupt bacterial membranes can be leveraged in the development of novel antimicrobial agents. -
Antibacterial Agent
Tebipenem is an orally available carbapenem antibiotic that exhibits broad-spectrum antibacterial activity against a variety of Gram-positive and Gram-negative bacteria, with the exception of Pseudomonas aeruginosa. It targets bacterial cell wall synthesis, making it a valuable tool in research focused on antimicrobial resistance and the development of new antibacterial therapies. Tebipenem is particularly relevant in studies aiming to characterize the pharmacodynamics and mechanisms of action of novel antibiotics. -
Antibiotic
Brilacidin tetrahydrochloride is a defensin mimetic antibiotic that exhibits potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It demonstrates minimum inhibitory concentrations (MIC90) of 1 μg/mL against Streptococcus pneumoniae and 8 μg/mL against Streptococcus viridans, alongside MIC90 values of 8 μg/mL for Haemophilus influenzae and 4 μg/mL for Pseudomonas aeruginosa. This compound is particularly valuable in microbiological research and the development of novel therapeutic strategies for bacterial infections. -
Antibiotic
Ertapenem disodium is a broad-spectrum β-lactam antibiotic known for its long-lasting activity against a wide range of pathogens. It exhibits significant anti-anaerobic efficacy, with a minimum inhibitory concentration (MIC) of 0.12 μg/mL against various anaerobic bacteria. This reagent is particularly useful in research focused on severe infections affecting the skin, lungs, stomach, pelvis, and urinary tract. -
Antibiotic
SPR206 acetate is a polymyxin analog that exhibits potent antibiotic activity against Gram-negative pathogens, including multidrug-resistant strains. Its mechanism involves disrupting the outer membrane of bacteria, leading to bactericidal effects. SPR206 acetate demonstrates low minimum inhibitory concentration (MIC) values of 0.125 mg/L against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301, making it a valuable tool in the study of bacterial infections and antibiotic resistance. -
Bacteriostatic Antibiotic
Trimethoprim lactate is a bacteriostatic antibiotic that functions as a dihydrofolate reductase inhibitor. It exhibits activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, making it valuable in research related to urinary tract infections, Shigellosis, and Pneumocystis pneumonia. Additionally, Trimethoprim lactate has been shown to inhibit Influenza A virus infection in chick embryos when used in combination with zinc. -
Bacteriostatic Antimycobacterial Agent
Ethambutol dihydrochloride is a bacteriostatic antimycobacterial agent that inhibits the activity of arabinosyltransferase, thereby preventing cell wall synthesis in Mycobacterium species. This compound is primarily utilized in research to study tuberculosis and other mycobacterial infections, as well as to establish animal models for hyperuricemia and optic neuropathy. Its mechanism and applications make it an important tool for investigating various microbial pathologies and associated therapeutic strategies. -
Parasite Inhibitor
Milbemycin oxime is an orally active macrolide that serves as a potent inhibitor of parasite activity. This compound, a mixture of oxime derivatives related to milbemycin A4 and A3, selectively binds to glutamate-gated chloride channels, leading to paralysis and death of various intestinal nematodes and lung/heart worms. It is widely utilized in research focused on antiparasitic drug development and mechanisms of parasitic resistance. -
Bacterial Biofilm Formation Inhibitor
Ethyl acetoacetate is an ester compound that acts as an inhibitor of bacterial biofilm formation. Its unique chemical structure facilitates its role in impairing the ability of bacteria to adhere and form protective biofilms, making it a valuable research tool in studying microbial resistance and infection control. This reagent is useful in various biological applications, particularly in investigations aimed at understanding bacterial behavior and developing new antimicrobial strategies. -
Antibiotic
Cefuroxime is a second-generation cephalosporin antibiotic that exerts its effects through inhibition of bacterial cell wall synthesis. It demonstrates a broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria while exhibiting enhanced stability to β-lactamase enzymes. Cefuroxime is widely utilized in research applications aimed at studying bacterial infections and antibiotic resistance. -
Aminoglycoside Antibiotic
Amikacin sulfate is an aminoglycoside antibiotic and a semisynthetic derivative of kanamycin, primarily targeting bacterial ribosomal subunits 30S and 50S to inhibit protein synthesis. This compound exhibits potent bactericidal activity against a wide range of Gram-negative bacteria, including strains resistant to gentamicin and tobramycin. Additionally, amikacin sulfate is effective against infections caused by susceptible Nocardia and nontuberculous mycobacteria, making it valuable in various microbiological research applications. -
Antibiotic
Colominic acid sodium salt is a polysaccharide derived from the cell wall of Escherichia coli and various animal sources. This compound exhibits antibacterial activity and is characterized by a distinctive red color, with an absorption maximum at 530 nm. It serves as a valuable tool in microbiological research, particularly for studying bacterial interactions and polysaccharide functions in biological systems. -
Antibacterial Antibiotic
Cephaloridine hydrate is a broad-spectrum antibacterial antibiotic that targets bacterial cell wall synthesis. It exhibits significant antibacterial activity against a variety of gram-positive and gram-negative organisms. Although effective, it is important to note that cephaloridine has been associated with dose-related nephrotoxicity, which should be considered in experimental applications. -
Antibiotic
Plazomicin sulfate is a semi-synthetic aminoglycoside antibiotic that primarily targets bacterial ribosomes to disrupt protein synthesis. It functions as a substrate for aminoglycoside acetyltransferase and aminoglycoside phosphotransferase while remaining unmodified by several common aminoglycoside-modifying enzymes. Plazomicin sulfate exhibits selective inhibition of MATE2-K and demonstrates significant efficacy against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales. This compound is valuable for research applications focusing on antibiotic resistance and the mechanisms of action of aminoglycosides. -
Antibiotic
Dalfopristin is a semisynthetic sulfone antibiotic that functions by inhibiting bacterial protein synthesis. Although Dalfopristin exhibits limited antibacterial activity on its own, it demonstrates significant bactericidal effects in synergy with Quinupristin, particularly against a range of pathogenic Gram-positive cocci. This compound is utilized in research focused on antibiotic resistance and the development of combination therapies for bacterial infections. -
Antibiotic
Cefquinome sulfate is a broad-spectrum cephem antibiotic that targets bacterial cell wall synthesis, effectively inhibiting a wide range of Gram-positive and Gram-negative bacteria. Its antibacterial activity extends to species such as Staphylococci, Streptococci, Pseudomonas, and Enterobacteriaceae. Cefquinome sulfate is primarily used in veterinary medicine for the treatment of bacterial infections, making it a valuable tool in microbiological research and antibiotic susceptibility studies. -
Antibiotic
SPR741 is a cationic peptide antibiotic derived from polymyxin B, functioning primarily as a potentiator. It enhances the permeability of the outer membrane in Gram-negative bacteria, making it an effective agent against multidrug-resistant strains. SPR741 is utilized in research focused on severe Gram-negative infections and can broaden the spectrum of activity when used in combination with other antibiotics. -
Antibiotic
Nalidixic acid sodium salt is a quinolone antibiotic targeting DNA gyrase and topoisomerase IV. It exhibits bacteriostatic activity at lower concentrations and becomes bactericidal at higher concentrations, effectively inhibiting DNA replication in susceptible gram-positive and gram-negative bacteria. This compound is valuable for microbiological research and antibiotic susceptibility testing, facilitating the study of bacterial infections and resistance mechanisms. -
Antibacterial Agent
Colistin methanesulfonate sodium salt is an antibacterial agent that primarily targets Gram-negative bacteria, including Pseudomonas aeruginosa. It demonstrates minimum inhibitory concentration (MIC) values ranging from 4 to 16 mg/L against susceptible strains, making it an essential compound for research in antimicrobial resistance and the efficacy of antibiotic treatments. This reagent is suitable for studies requiring a focus on antibiotic susceptibility and the mechanisms of action of colistin derivatives. -
Antibiotic
Nosiheptide is a thiopeptide antibiotic that targets bacterial protein synthesis. It is produced by Streptomyces actuosus and features a unique indole side ring system along with regiospecific hydroxyl groups on its macrocyclic core. Nosiheptide is utilized in research applications focused on antimicrobial activity and has also been used as a feed additive to promote animal growth. -
Antibiotic
Lefamulin acetate is an orally active antibiotic that targets bacterial protein synthesis by binding to the peptidyl transferase center of the 50S ribosomal subunit. This mechanism disrupts bacterial growth and has been shown to possess anti-inflammatory properties. Lefamulin acetate is applicable in research focused on bacterial infections, including those caused by pneumonia-inducing pathogens. -
Antibacterial Agent
Pectin is a heteropolysaccharide primarily derived from the cell walls of higher plants, functioning as an effective antibacterial agent. It exhibits broad-spectrum antimicrobial activity, binding to bacterial toxins and irritants in the intestinal mucosa, thereby alleviating mucosal irritation. Additionally, pectin serves as a versatile agent for the formation of nanoparticles, facilitating the delivery of therapeutic compounds. Its properties make it valuable for research in gastrointestinal health and drug delivery systems. -
Antibiotic
Virginiamycin M1 is a polyunsaturated macrocyclic lactone antibiotic derived from Streptomyces virginiae. It exhibits significant antibacterial activity against Staphylococcus aureus, with a minimal inhibitory concentration (MIC) of 0.25 μg/mL. This compound is commonly utilized in research applications to investigate antibiotic mechanisms and resistance, as well as for the study of bacterial pathogens. -
Antibiotic
Framycetin sulfate, an aminoglycoside antibiotic, primarily targets RNase P, functioning as a potent inhibitor of its cleavage activity with a Ki of 35 μM. It competes for divalent metal ion binding sites within RNase P RNA, effectively inhibiting the hammerhead ribozyme with a Ki of 13.5 μM. Additionally, as a 5″-azido neomycin B precursor, Framycetin sulfate binds to the Drosha site in miR-525, making it applicable in the study of hepatic encephalopathy and enteropathogenic E. coli infections. -
Antibiotic
Nemadectin is an orally active broad-spectrum endectocide that targets gastrointestinal helminths. It demonstrates potent anthelmintic activity, making it effective against natural infections in canines caused by major helminth species. This compound is valuable for research applications focused on parasitic infections and the development of novel anthelmintic therapies. -
Antibiotic
Kanamycin sulfate is a broad-spectrum aminoglycoside antibiotic that primarily targets bacterial protein synthesis by binding to the 30S ribosomal subunit. This reagent is effective against a range of bacterial infections, particularly those caused by certain staphylococci and Gram-negative bacilli. However, caution is advised due to its potential ototoxic effects. Kanamycin sulfate is commonly utilized in microbiological research and treatment protocols for severe bacterial infections. -
Antibiotic
Cefpodoxime is a broad-spectrum antibiotic that exhibits activity against a variety of gram-positive and gram-negative bacteria. Its primary mechanism of action involves inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Cefpodoxime is useful for research applications related to acute otitis media, sinusitis, and tonsillopharyngitis, enabling investigations into microbial resistance and treatment efficacy. -
Tetracycline Antibiotic
Demeclocycline is an orally active tetracycline antibiotic that targets bacterial protein synthesis. It functions by binding to the 30S ribosomal subunit, effectively inhibiting the binding of aminoacyl-tRNA. Demeclocycline demonstrates antibacterial activity against a broad spectrum of bacterial infections and is utilized in various research applications related to antibiotic resistance and microbial pathogenesis. -
Antibiotic
Gentamicin C1a is an aminoglycoside antibiotic that primarily targets bacterial ribosomes, inhibiting protein synthesis. As the major component of the Gentamicin complex, it exhibits significant antibacterial activity against a wide range of Gram-negative and some Gram-positive bacteria. Gentamicin C1a is commonly employed in microbiological research and clinical studies to evaluate antibacterial efficacy and resistance mechanisms. -
Antibiotic Agent
Cloxacillin sodium is a β-lactam antibiotic and a potent β-lactamase inhibitor with an IC50 of 0.04 µM. It exhibits significant antibacterial activity, particularly against Staphylococcus aureus, and can effectively attenuate the S. aureus-induced inflammatory response by inhibiting the activation of MAPK, NF-κB, and NLRP3-related proteins. This compound is relevant for research in antimicrobial resistance and inflammation pathways. -
Antibiotic
Lefamulin is an orally active antibiotic that primarily targets bacterial protein synthesis by binding to the peptidyl transferase center of the 50S ribosomal subunit. This binding effectively inhibits the formation of peptide bonds, leading to disruption of bacterial growth. In addition to its antimicrobial properties, Lefamulin exhibits anti-inflammatory activity. It is valuable for research applications focused on bacterial infections, including conditions such as bacterial pneumonia. -
Antibiotic
Amoxicillin-clavulanate potassium is a combination antibiotic that targets bacterial cell wall synthesis and inhibits beta-lactamase enzymes. It exhibits broad-spectrum antibacterial activity against a variety of Gram-positive and Gram-negative pathogens. This reagent is commonly utilized in research to study bacterial infections and evaluate potential therapeutic strategies for combating antibiotic resistance. -
Antibiotic
Contezolid is an orally active oxazolidinone antibiotic targeting resistant Gram-positive bacteria. It demonstrates significant efficacy against complicated skin and soft tissue infections (cSSTI) while exhibiting a reduced risk of myelosuppression and minimal monoamine oxidase inhibition. This unique profile makes Contezolid a promising candidate for the treatment of infections caused by resistant strains. -
Antibacterial Agent
Ceftolozane is a cephalosporin antibiotic that specifically targets bacterial infections by inhibiting cell wall synthesis. It exhibits potent antibacterial activity against Pseudomonas aeruginosa and various Enterobacteriaceae strains, with minimal inhibitory concentrations (MICs) reported at 0.5 mg/L and 0.25-0.5 mg/L, respectively. This reagent is valuable for research applications focused on antibiotic resistance and the development of new therapeutic strategies. -
Antibiotic
Mupirocin lithium is an antibiotic that targets bacterial isoleucyl-tRNA synthetase, effectively inhibiting protein synthesis. This compound exhibits potent activity against a range of Gram-positive bacteria, including Staphylococcus and Streptococcus, as well as certain Gram-negative strains such as Haemophilus influenzae. Mupirocin lithium is utilized in research focused on skin infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA), and chronic sinusitis.
