Other inhibitors

Diosmetin is an O-methylated flavone, a chemical compound that can be found in the Caucasian vetch.

Ribitol is a crystalline pentose alcohol formed by the reduction of ribose.

Nobiletin is a chemical compound. It is an O-methylated flavone, a flavonoid isolated from citrus peels like in tangerine. Nobiletin was found to have anti-inflammatory and anti-tumor invasion, proliferation, and metastasis in vitro and in vivo. Nobiletin was also found to potentially inhibit cartilage degradation.

Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.

Rutin is one of the phenolic compounds found in the invasive plant species Carpobrotus edulis and contributes to the antibacterial and antioxidant properties of the plant

Iopamidol is a non-ionic, water-soluble radiographic contrast agent.

Theobromine(3,7-Dimethylxanthine) is a xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than theophylline and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension.

Ioversol is low osmolality, nonionic, radiographic contrast agent.

Cefdinir is a third generation oral cephalosporin antibiotic.

Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic (anti-itching drug).

Oxacillin sodium monohydrate is an antibacterial agent and is a narrow spectrum beta-lactam antibiotic of the penicillin class.

Pristinamycin is an antibiotic used primarily in the treatment of staphylococcal infections, and to a lesser extent streptococcal infections.

Meropenem is a β-lactam antibiotic of the carbapenem subclass that has been shown to inhibit penicillinase-negative, -positive and methicillin-susceptible staphylococci.

Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria

Rifapentine is an antibiotic drug used in the treatment of tuberculosis.

5-BrdU is a synthetic thymidine analog; incorporated into DNA during replication. Used in assays for cell proliferation.

Dihydroartemisinin is the active metabolite of all artemisinin compounds (artemisinin, artesunate, artemether, etc.) and is also available as a drug in itself. It is a semi-synthetic derivative of artemisinin and is widely used as an intermediate in the preparation of other artemisinin-derived antimalarial drugs.

Paroxetine is an antidepressant drug of the SSRI type.

Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone, which is secreted from the prothoracic glands.

Haematoxylin is extracted from the heartwood of the logwood tree.When oxidized it forms haematein, a compound that forms strongly coloured complexes with certain metal ions, the most notable ones being Fe(III) and Al(III) salts. Metal-haematein complexes are used to stain cell nuclei prior to examination under a microscope.

Zanamivir is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.

Streptozotocin (Streptozocin, Zanosar, STZ)is used in medical research to produce an animal model for Type 1 diabetes, which directly inhibist the O-GlcNAcase activity of the enzyme NCOAT in vitro.

Sinomenine(Cucoline) is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and arthritis.

Tirapazamine is a bioreductive, anti-neoplastic, anti-cancer agent that is selectively toxic to cells under hypoxic conditions.

AdipoRon is a novel small-molecule AdipoR agonist; binds to both AdipoR1(Kd= 1.8 uM) and AdipoR2(Kd=3.1 uM). IC50 value: 1.8/3.1 uM(AdipoR1/2, Kd)

Osthole(Osthol) is a type of coumarin.

Laquinimod (ABR-215062) is a potent immunomodulator.

Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015.

QS-11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor.

Troxacitabine is a nucleoside analogue with anticancer activity. Its use is being studied in patients with refractory lymphoproliferative diseases.

P005672 is a phase II drug for antibacterial/anti-inflammatory acne treatment.

Cefozopran is a fourth-generation cephalosporin. It would be effective against respiratory tract, urinary tract, and soft tissue infections caused by a variety of gram-positive and gram-negative bacteria in humans.

Azafen is a tricyclic antidepressant.It acts as a potent inhibitor of the reuptake of serotonin.

Besifloxacin is a fourth-generation fluoroquinolone antibiotic.

Calcipotriol hydrate is the hydrate form of vitamin D3 that displays minimal effects on calcium homeostasis.

CB 300919 is a potential therapy for ovarian cancer. Preclinical data showed that this quinazoline-based compound CB 300919 has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft

Caspofungin is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals.

Cot inhibitor-1 is a COT/Tpl2 inhibitor.

Collagen proline hydroxylase inhibitor-1 is an antifibroproliferative agents.

Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars.

LY2608204 is a potent used to treat type 2 diabetes. In a clinical trial, a study was performed to evaluate the safety and tolerability of LY2608204 in patients with type 2 diabetes.

D-Fagomine is an iminosugar originally isolated from seeds of buckwheat (Fagopyrum sculentum Moench)

Glyoxalase I inhibitor is a potent Glyoxalase I inhibitor, candidate for anticancer agents.

BD-AcAc 2, added in diet, could elevated mean blood ketone bodies of 3.5 mm and lowered plasma glucose, insulin, and leptin in animals; ketone ester given orally would delay CNS-OT seizures in rats breathing hyperbaric oxygen.

Ko 143 is potent and selective inhibitor of breast cancer resistance protein multidrug transporter (BCRP) with an EC90 value of 26 nM.

Rocuronium (Org-9426) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia.

Salmefamol is useful for treatment of respiratory diseases

Tedizolid (TR-701) is a novel oxazolidinone antibacterial agent.

Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice.

Clindamycin palmitate HCl is a water soluble hydrochloride salt of the ester of clindamycin and palmitic acid and a lincosamide antibiotic.