Catalog No.
Product Name
Application
Product Information
Citations
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Thrombin
Desethyl KBT-3022 is the primary active metabolite of the novel antiplatelet agent KBT-3022, targeting thrombin. This compound inhibits thrombin activity, playing a significant role in the regulation of blood coagulation and platelet aggregation. Its primary applications include studies on thrombosis, hemostasis, and the development of therapeutic strategies for cardiovascular diseases. -
Tyrosinase Inhibitor
(E)-2-Methoxycinnamaldehyde is a potent inhibitor of tyrosinase, demonstrating an IC50 of 0.42 mM for mushroom tyrosinase. Isolated from the twigs of Cinnamomum cassia, this compound is relevant in the study of melanin biosynthesis as well as potential applications in skin depigmentation. Additionally, (E)-2-Methoxycinnamaldehyde has been investigated for its role in Parkinson's disease research, providing insights into neuroprotective strategies. -
Tyrosinase Inhibitor
Isobutylamido thiazolyl resorcinol is a selective inhibitor of human tyrosinase with an IC50 of 1.1 μM, demonstrating notable efficacy against melanin production. This compound also shows an IC50 of 108 μM against mushroom tyrosinase, highlighting its specificity. Isobutylamido thiazolyl resorcinol effectively mitigates pigmentation induced by UVB exposure and significantly reduces the visibility of hyperpigmentation related to acne. Its applications in dermatological research make it a valuable tool for studying skin pigmentation processes and developing treatments for skin discoloration disorders. -
Tyrosinase Inhibitor
3',4'-Dihydroxyacetophenone is a potent tyrosinase inhibitor, demonstrating a strong inhibitory effect on enzyme activity with an IC50 value of 10 μM. Isolated from Picea schrenkiana needles, this compound also exhibits antioxidant properties and vasoactive effects, making it valuable for research applications in skin pigmentation and melanogenesis. Its ability to modulate tyrosinase activity positions it as a useful tool in studies related to pigmentation disorders and cosmetic formulations. -
Tyrosinase Inhibitor
(R)-Trolox is a vitamin E analogue and a competitive inhibitor of tyrosinase, exhibiting a Ki value of 0.83 mM and an ID50 of 1.88 mM. This compound demonstrates a greater affinity for tyrosinase compared to its (S) enantiomer, which has a Ki value of 0.61 mM. (R)-Trolox is valuable for research focused on skin pigmentation, oxidative stress, and potential therapeutic applications in disorders related to hyperpigmentation. -
Tyrosinase Inhibitor
Mulberroside F acts as a potent tyrosinase inhibitor, primarily derived from the mulberry plant (Morus alba L.). This compound effectively inhibits tyrosinase activity, leading to a reduction in melanin formation, making it valuable in research related to hyperpigmentation and skin disorders. Additionally, Mulberroside F demonstrates superoxide scavenging activity, contributing to its protective effects against oxidative stress. -
Tyrosinase Inhibitor
4-Bromobenzoic acid is a potent inhibitor of tyrosinase, with an IC50 range of 0-0.3 mg/mL. This compound plays a significant role in the study of melanin biosynthesis and is applicable in research focused on cosmetic whitening and pigmentation disorders. Its metabolism via the protocatechuic acid (PCA) pathway provides additional insights into its biochemical interactions and potential therapeutic benefits. -
Tyrosinase Inhibitor
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound that acts as an effective inhibitor of the enzyme tyrosinase, exhibiting an IC50 of 29.75 μM. This compound plays a significant role in regulating melanin production and is of interest in research applications related to skin pigmentation disorders and cosmetic formulations. Its inhibitory effect on tyrosinase makes it a valuable reagent for studies exploring pigmentary conditions and related therapeutic interventions. -
Tyrosinase Inhibitor
5-Feruloylquinic acid is a potent inhibitor of tyrosinase, an enzyme involved in melanin biosynthesis. Isolated from green coffee beans, this hydroxycinnamic acid derivative exhibits significant antioxidant properties and has demonstrated anticancer activity against various cancer types, including lymphoma, oral epidermal cancer, and breast cancer. Its ability to modulate enzymatic activity and protect against oxidative stress makes it a valuable compound for research in cancer biology and metabolic studies. -
Tyrosinase Inhibitor
Mirificin, a tyrosinase inhibitor derived from Puerariae Lobatae Radix, demonstrates inhibitory activity with an IC50 of 12.66 μM. This isoflavone is of particular interest in studies related to pigmentation disorders and skin hyperpigmentation, offering a potential therapeutic avenue for regulating melanin synthesis. Its ability to modulate tyrosinase activity underscores its relevance in chemical and pharmacological research applications. -
Tyrosinase Inhibitor
2-Methoxycinnamic acid is a noncompetitive inhibitor of tyrosinase, an enzyme critical in melanin biosynthesis. This compound effectively reduces melanin production, making it valuable in studies focused on pigmentation disorders and skin whitening applications. Its ability to modulate tyrosinase activity positions it as a significant reagent for research in dermatology and cosmetic science. -
Tyrosinase Iinhibitor
Dihydromorin is a natural flavanonol compound that acts as a potent inhibitor of tyrosinase. Its inhibitory activity on this enzyme is significant for research applications focused on regulating melanin production, offering potential insights into hyperpigmentation disorders and skin-related studies. Dihydromorin can serve as an important tool for investigating mechanisms of skin pigmentation and the effects of natural compounds on melanin synthesis. -
Tyrosinase Inhibitor
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound that serves as an effective inhibitor of tyrosinase, with an IC50 value of 1.64 μM. This compound is derived from Morus nigra root and exhibits significant potential for applications in studies related to pigmentation and skin disorders. Its inhibitory action on tyrosinase makes it a valuable tool for research in cosmetic and dermatological fields. -
Tyrosinase Inhibitor
Neorauflavane is a potent inhibitor of tyrosinase, exhibiting an IC50 of 30 nM for monophenolase activity and 500 nM for diphenolase activity. Derived from Campylotropis hirtella, this compound effectively reduces melanin content in B16 melanoma cells. Neorauflavane serves as a valuable tool for research in pigmentation disorders and skin biology. -
Tyrosinase Inhibitor
Tyrosinase-IN-11 is a potent inhibitor of tyrosinase, exhibiting IC50 values of 50 nM for L-tyrosinase and 64 nM for L-dopa. This compound demonstrates significant antioxidant properties and low cytotoxicity, making it suitable for biological assays. Tyrosinase-IN-11 is particularly relevant for research into skin hyperpigmentation and related dermatological applications. -
Mushroom Tyrosinase Inhibitor
Sanggenon O is a potent inhibitor of mushroom tyrosinase, demonstrating an IC50 value of 1.15 μM. This compound, derived from Morus nigra, is valuable for research applications focused on enzymatic activity modulation, particularly in studies related to melanin biosynthesis and skin pigmentation. Its inhibitory effects on tyrosinase make it a useful tool in cosmetic and therapeutic research aimed at addressing hyperpigmentation and related conditions. -
Tyrosinase Inhibitor
Obtusifolin-2-O-glucoside is a potent inhibitor of tyrosinase, demonstrating an IC50 value of 9.2 μM. This compound, which can be isolated from cassia seed, has significant implications in the study of melanogenesis and skin pigmentation. Its inhibitory properties make it a valuable tool for research into hyperpigmentation disorders and skin-lightening agents. -
Tyrosinase Inhibitor
Viscumneoside III is a dihydroflavone O-glycoside that functions as a potent inhibitor of tyrosinase, exhibiting an IC50 value of 0.5 mM. This compound demonstrates significant anti-angina pectoris activity, making it a valuable reagent for research into melanogenesis and cardiovascular health. Its ability to modulate tyrosinase activity further supports its applications in studies related to pigmentation disorders and metabolic conditions. -
Tyrosinase Inhibitor
Isolindleyin is a butyrophenone that acts as a potent inhibitor of tyrosinase, exhibiting a Kd of 54.8 μM in human tyrosinase assays. This compound demonstrates notable anti-inflammatory, analgesic, and anti-melanogenic activities, making it valuable for research in skin-related disorders and the modulation of pigmentation processes. Its multifunctional properties position it as a significant tool for studying enzyme inhibition and related biological pathways. -
Tyrosinase Inhibitor
Chimonanthine is an alkaloid derived from Chimonanthus praecox, known for its ability to inhibit tyrosinase activity. This compound also reduces the expression of tyrosine-related protein-1 mRNA, leading to the suppression of melanogenesis. Due to its mechanism of action, Chimonanthine is valuable in research focused on pigmentation disorders and potential therapeutic applications in hyperpigmentation conditions. -
Tyrosinase Inhibitor
Kojic acid dipalmitate is a derivative of kojic acid and functions as a reversible competitive inhibitor of tyrosinase. This compound is primarily studied for its skin-lightening properties due to its ability to inhibit melanin production. It is frequently utilized in research applications aiming to understand pigmentation mechanisms and the development of cosmetic agents targeting hyperpigmentation disorders. -
Tyrosinase Inhibitor
6-Hydroxykaempferol is a competitive inhibitor of tyrosinase, exhibiting an IC50 value of 124 μM. This flavonoid demonstrates a Ki value of 148 μM when L-DOPA serves as the substrate, effectively inhibiting the enzymatic activity by binding to the active site. Its inhibitory properties make it a valuable tool for research in skin pigmentation, cosmetic formulations, and enzymatic activity studies related to melanogenesis. -
Tyrosinase Inhibitor
Tyrosinase-IN-16 is a potent inhibitor of tyrosinase, exhibiting a Ki value of 470 nM. This compound demonstrates significant cytotoxicity against B16F10 melanoma cells, achieving over 90% inhibition at a concentration of 20 μM. Tyrosinase-IN-16 is valuable for studies investigating mechanisms of melanin synthesis and potential therapeutic applications in pigmentary disorders and melanoma research. -
Tyrosinase Inhibitor
Tyrosinase-IN-3 is a potent inhibitor of tyrosinase, a copper-containing metalloenzyme that catalyzes the rate-limiting step in melanin biosynthesis and enzymatic browning processes. This compound exhibits significant biological activity in mitigating melanin production, making it valuable for research into skin whitening agents and food preservatives. Its application potential extends to various fields requiring modulation of pigmentation and oxidative reactions. -
Tyrosinase Inhibitor
4-Prenyloxyresveratrol is a derivative of oxyresveratrol that functions as a potent inhibitor of tyrosinase, exhibiting an IC50 of 0.90 μM. This compound demonstrates significant biological activity in inhibiting melanin production, making it valuable in research applications related to pigmentation disorders, skin protection, and potential therapeutic interventions in hyperpigmentation. -
Tyrosinase Inhibitor
Tyrosinase-IN-5 is a highly potent inhibitor of tyrosinase, exhibiting an IC50 value of 0.02 μM. This compound effectively suppresses melanogenesis while demonstrating minimal cytotoxicity to cells. Tyrosinase-IN-5 is applicable in research focused on skin pigmentation disorders and the development of skin-lightening agents. -
Tyrosinase Inhibitor
Tyrosinase-IN-1 is a potent inhibitor of the enzyme tyrosinase, a copper-containing metalloenzyme integral to melanin biosynthesis and enzymatic browning processes. This compound demonstrates significant biological activity as a tyrosinase inhibitor, making it a valuable tool for research into skin whitening agents and food preservation applications. Its effectiveness in modulating tyrosinase activity positions it as a key reagent for studies aimed at understanding pigmentation mechanisms and enhancing food shelf life. -
Tyrosinase Inhibitor
Phaeosphaone D is a thiodiketopiperazine alkaloid that demonstrates strong inhibitory activity against tyrosinase, an enzyme critical in melanin biosynthesis. Isolated from the endophytic fungus Phaeosphaeria fuckelii, Phaeosphaone D exhibits an IC50 value of 33.2 μM, indicating its potency. This compound is valuable for research applications focused on skin pigmentation, melanoma, and potential therapeutic strategies for hyperpigmentation disorders. -
Tyrosinase Inhibitor
Tyrosinase-IN-7 is a potent inhibitor of tyrosinase, exhibiting an IC50 value of 1.57 µM. This compound demonstrates effective inhibition of cell growth while maintaining low cytotoxicity, making it suitable for research applications focused on melanin synthesis and related disorders. Its unique properties position it as a valuable tool in the study of pigmentation mechanisms and potential therapeutic interventions. -
Tyrosinase Inhibitor
6-Acetylnimbandiol is a non-cytotoxic tyrosinase inhibitor that demonstrates an IC50 value of 69.85 μM, effectively reducing melanin production and MITF expression. This compound is valuable for investigating the mechanisms of pigmentation and has potential applications in melanoma research. -
Tyrosinase Inhibitor
2,3-Dihydroisoginkgetin is a biflavonoid that functions as a potent inhibitor of tyrosinase, exhibiting a 36.84% inhibition rate at a concentration of 0.1 mM. This compound demonstrates reduced cytotoxicity in human epidermal melanocyte (HEMn) cells, with an IC50 value of 86.16 μM. 2,3-Dihydroisoginkgetin is valuable for research applications focused on skin pigmentation, melanin production, and potential therapeutic strategies for hyperpigmentation disorders. -
Tyrosinase Inhibitor
Tyrosinase-IN-4 is a potent inhibitor of the enzyme tyrosinase, a copper-containing metalloenzyme that catalyzes the rate-limiting step in melanin biosynthesis, which is essential for pigmentation in various biological systems. This compound has significant implications for research in skin whitening agents and food preservation, making it a valuable tool for studies focused on reducing pigmentation and preventing enzymatic browning in food products. -
Mushroom Tyrosinase Diphenolase Inhibitor
Tyrosinase-IN-33 is a pyridine-based compound that acts as a potent inhibitor of mushroom tyrosinase diphenolase activity. It effectively reduces enzyme activity, with an IC50 value of 9.0 μM, making it a valuable tool for research into melanogenesis and related disorders. This compound is suitable for studies investigating enzymatic inhibition and the regulation of pigmentation processes. -
Tyrosinase Inhibitor
Tyrosinase-IN-44 is a potent inhibitor of tyrosinase, exhibiting IC50 values of 0.47 μM for monophenolase activity and 0.53 μM for diphenolase activity. This compound demonstrates significant antioxidant properties through its glutathione peroxidase-like catalytic function and DPPH radical scavenging ability. Tyrosinase-IN-44 effectively prevents browning in fruit juices, particularly in banana and apple, by inhibiting polyphenol oxidase (PPO). Its applications extend to redox regulation and food preservation, making it a valuable reagent in biochemical research. -
Tyrosinase Inhibitor
Cardanol diene is a phenolic compound that acts as an inhibitor of tyrosinase, exhibiting an IC50 value of 52.5 μM in vitro. It is utilized in research aimed at exploring pigmentation processes and has applications in the synthesis of cardanol-metal complexes, which have been shown to inhibit biofilm formation by uropathogenic E. coli. -
Tyrosinase Inhibitor
Broussonin C is a competitive inhibitor of tyrosinase, a key enzyme involved in melanin biosynthesis. Isolated from Broussonetia kazinoki, Broussonin C exhibits potent inhibitory activity with IC50 values of 0.43 μM for monophenolase and 0.57 μM for diphenolase. This compound is valuable for research applications focused on skin pigmentation, oxidative stress, and potential therapeutic interventions in hyperpigmentation disorders. -
tyrosinase Inhibitor
Tyrosinase-IN-27 is a selective tyrosinase (TYR) inhibitor with an IC50 value of 0.88 μM. This compound acts by binding to TYR, resulting in a decrease in α-helical content and altering the enzyme's secondary structure, leading to reduced enzymatic activity. Tyrosinase-IN-27 has potential applications in the food industry, specifically for preventing enzymatic browning in products such as lotus root slices. -
Tyrosinase Inhibitor
7-Methoxy obtusifolin acts as a competitive inhibitor of tyrosinase, exhibiting an IC50 value of 7.0 μM. This compound is utilized in studies focused on melanogenesis and pigmentation disorders, making it a valuable tool for research in skin biology and potential therapeutic development for hyperpigmentation conditions. -
Tyrosinase Inhibitor
Tyrosinase-IN-2 is a selective inhibitor of the enzyme tyrosinase, a copper-containing metalloenzyme that catalyzes the critical step in melanin biosynthesis and contributes to enzymatic browning. This compound demonstrates significant inhibitory activity, making it a valuable tool for research in skin whitening agents and food preservation applications. Its ability to modulate melanin production positions Tyrosinase-IN-2 as a promising candidate for studies focused on pigmentation and related processes. -
Tyrosinase Inhibitor
Tyrosinase-IN-10 is a partially competitive inhibitor of tyrosinase, exhibiting an IC50 of 1.6 μM against tyrosinase activity in human melanoma cell lysates. This compound is valuable for research applications focused on melanin production and skin disorders, as well as for studying the biochemical pathways associated with tyrosinase. Its specific inhibition properties make it a useful tool for exploring potential therapeutic strategies in pigmentation-related conditions. -
Tyrosinase Inhibitor
Glabrene is an isoflavene derived from licorice root, functioning primarily as a tyrosinase inhibitor with an IC50 of 3.5 μM. It exhibits estrogen-like activity and is utilized in research investigating skin pigmentation, melanogenesis, and potential therapeutic applications in hyperpigmentation disorders. Its ability to modulate enzymatic activity makes it a valuable reagent for studies related to skin biology and pigmentation regulation. -
Tyrosinase inhibitor
Allamandicin is an iridoid lactone that acts as a potent inhibitor of tyrosinase. Isolated from the roots of Allamanda cathartica, Allamandicin exhibits significant biological activity by effectively reducing melanin production. This compound is valuable in research applications focused on skin pigmentation, cosmetics, and potential therapeutic strategies for conditions related to hyperpigmentation. -
Tyrosinase Inhibitor
Persiconin is a potent inhibitor of tyrosinase, an enzyme crucial for melanin synthesis. Isolated from Prunus persica, Persiconin exhibits a notable tyrosinase inhibitory activity, achieving an inhibition of 46% at a concentration of 500 μM. This compound is particularly valuable in research applications focused on skin whitening and pigmentation modulation. -
Tyrosinase Inhibitor
Tyrosinase-IN-17 is a potent inhibitor of tyrosinase, exhibiting a lipophilic nature and skin permeability with a pIC50 value of 4.99. This compound demonstrates non-cytotoxic properties, making it suitable for in vitro studies. Tyrosinase-IN-17 is primarily employed in research related to melanin synthesis and disorders, including melanoma and other melanogenesis-related diseases. -
Tyrosinase Inhibitor
Tyrosinase-IN-31 is a selective inhibitor of tyrosinase, targeting both monophenolase (IC50=70.44 μM) and diphenolase (IC50=1.89 μM) activities. This compound effectively inhibits tyrosinase and melanogenesis, demonstrating potential applications in skin depigmentation research. Additionally, Tyrosinase-IN-31 exhibits the ability to penetrate the blood-brain barrier, allowing it to enter the central nervous system, where it may confer neuroprotective effects and improve symptoms related to Parkinson's disease. -
Tyrosinase Inhibitor
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is a potent tyrosinase inhibitor that effectively reduces melanin synthesis. Isolated from Pteris fern, this compound targets the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF), modulating melanin production. Key structural features including the 11α-OH, 15-oxo, and 16-en functionalities contribute to its inhibitory effects on melanin synthesis, while the 19-COOH moiety may help mitigate cytotoxicity associated with related compounds. This reagent is valuable in research focused on skin pigmentation and potential therapeutic applications for hyperpigmentation disorders. -
Tyrosinase Inhibitor
Tyrosinase-IN-35 is a potent inhibitor of human tyrosinase, exhibiting an IC50 of 2.09 μM, significantly surpassing the efficacy of Kojic Acid, which has an IC50 of 16.38 μM. This compound effectively reduces melanin content in B16F10 melanoma cells in vitro at concentrations of 4 μM and 8 μM. Tyrosinase-IN-35 serves as a valuable tool for research in pigmentation disorders and related therapeutic applications. -
Mushroom Tyrosinase Inhibitor
Chetoseminudin B is a potent inhibitor of mushroom tyrosinase, exhibiting an IC50 value of 31.7 μM. This compound is significant for research applications focused on melanin biosynthesis, pigmentation disorders, and potential cosmetic formulations aimed at skin lightening. Its ability to modulate enzymatic activity makes it valuable for investigating the role of tyrosinase in various biological processes. -
Tyrosinase Inhibitor
Sorocein H is a potent inhibitor of tyrosinase, demonstrating an IC50 value of 6.49 μM. This compound effectively reduces melanin synthesis and serves as a valuable tool in the study of pigment-related disorders. Research applications include investigations into skin pigmentation and related pathological conditions. -
Tyrosinase Inhibitor
Aspochalasin I is a potent tyrosinase inhibitor that effectively suppresses melanogenesis, achieving an IC50 of 22.4 μM. This compound also demonstrates cytotoxic effects against various cancer cell lines, including NCI-H460, MCF-7, and SF-268, with IC50 values of 22.1, 33.4, and 19.9 μM, respectively. Due to its role in inhibiting melanin production, Aspochalasin I can be utilized in research aimed at developing skin whitening agents and exploring therapeutic avenues in cancer treatment.
