Catalog No.
Product Name
Application
Product Information
Citations
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Tyrosinase
Tyrosinase-IN-6 is a potent inhibitor of the enzyme tyrosinase, exhibiting an IC50 value of 3.80 μM. This compound demonstrates notable antioxidant activity, making it valuable for research applications focused on pigmentation pathways and oxidative stress. Tyrosinase-IN-6 can be utilized in studies aimed at understanding skin disorders, melanin production, and developing cosmetic or therapeutic agents targeting hyperpigmentation. -
Tyrosinase Inhibitor
Dodoviscin A is a potent tyrosinase inhibitor that can be derived from the aerial parts of Dodonaea viscosa. It effectively reduces melanin production in B16-F10 melanoma cells and significantly suppresses mushroom tyrosinase activity. In addition, Dodoviscin A inhibits the phosphorylation of cAMP response element binding protein, which is stimulated by 3-isobutyl-1-methylxanthine and forskolin, making it a valuable tool for research applications focused on pigmentation and related signaling pathways. -
Tyrosinase Inhibitor
Tyrosinase-IN-37 is a potent inhibitor of tyrosinase, displaying an IC50 of 1.02 μM, significantly more effective than kojic acid, which has an IC50 of 14.74 μM. This compound demonstrates the capability to prevent browning in Rosa roxburghii and offers broader applications by inhibiting browning processes independent of tyrosinase activity. Its efficacy makes Tyrosinase-IN-37 a valuable tool in research focused on pigmentation and enzymatic regulation. -
Tyrosinase Inhibitor
Azo-resveratrol is a potent inhibitor of tyrosinase, demonstrating an IC50 value of 36.28 μM. This compound is particularly relevant for research applications focused on melanogenesis, skin pigmentation disorders, and potential therapeutic interventions for hyperpigmentation. Azo-resveratrol's ability to modulate tyrosinase activity highlights its significance in biochemical studies related to melanin synthesis. -
Tyrosinase Inhibitor
Mycosporine 2 glycine is a selective inhibitor of tyrosinase-related protein 1 (TYRP1), demonstrating strong binding affinity and stability. This compound exhibits biological activity that can modulate melanogenesis, making it valuable in research focused on hyperpigmentation disorders. Additionally, Mycosporine 2 glycine is commonly utilized in sunscreen formulations due to its protective properties against UV-induced skin damage. -
Tyrosinase Inhibitor
Tyrosinase-IN-42 is a potent inhibitor of tyrosinase, exhibiting an IC50 of 1.363 µM. This compound demonstrates significant anti-browning effects in fresh-cut apples and exhibits antioxidant properties through scavenging of DPPH and ABTS free radicals, with IC50 values of 57.90 µM and 45.64 µM, respectively. Tyrosinase-IN-42 is useful in research applications focused on food preservation and the study of oxidative stress. -
Tyrosinase Inhibitor
Taraxinic acid is a potent inhibitor of tyrosinase, an enzyme crucial for melanin biosynthesis. Derived from the roots of Taraxacum flavostylum and Taraxacum lucidum, it exhibits a dose-dependent inhibition of tyrosinase activity, achieving approximately 54.5% inhibition at 50 μg/mL. Additionally, Taraxinic acid demonstrates cytotoxic effects against melanoma cell lines A375 and HTB140 with an IC50 of 83.2 μM, and WM793 with an IC50 of 60.4 μM, indicating significant potential for applications in anticancer research. -
Tyrosinase Activator
5-epi-Arvestonate A is a sesquiterpenoid that acts as a tyrosinase activator, enhancing melanogenesis through the activation of the microphthalmia-associated transcription factor (MITF) and genes within the tyrosinase family. This compound furthermore exhibits anti-inflammatory properties by inhibiting the expression of interferon-gamma (IFN-γ)-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells. Its biological activity makes it a valuable reagent for research in dermatological studies and pigmentation processes. -
Tyrosinase Inhibitor
FQ is a potent tyrosinase inhibitor, specifically designed to inhibit the diphenolase activity of mushroom tyrosinase, with an IC50 value of 120 μM. This reagent is valuable for research applications focusing on pigmentation processes, allowing investigators to explore the biochemical pathways associated with melanin synthesis and regulation. Its ability to modulate tyrosinase activity makes FQ a critical tool in dermatological and cosmetic research. -
Tyrosinase Inhbitor
Tyrosinase-IN-20 is a potent inhibitor of tyrosinase, exhibiting an IC50 of 28.50 μM. This compound effectively dampens melanin production by inhibiting the enzymatic activity of tyrosinase, making it valuable for research into pigmentation disorders and skin-related applications. Its ability to modulate melanin synthesis allows for exploration in fields such as dermatology and cosmetic formulations. -
Tyrosine Aminopeptidases Substrate
H-Tyr-AMC is a fluorogenic substrate specifically designed for tyrosine aminopeptidases. Its biological activity includes serving as an inhibitor of tobacco and potato hydroxycinnamoyl-CoA:tyramine N-(hydroxycinnamoyl)transferase (THT), demonstrating Ki values of 0.72 μM and 0.42 μM, respectively. This compound is valuable for research applications involving enzyme kinetics and substrate specificity in plant biochemistry. -
HER2-RAS-MEK-ERK signaling pathway Modulator, mushroom tyrosinase Inhibitor
Broussoflavonol F is a modulator of the HER2-RAS-MEK-ERK signaling pathway and an inhibitor of mushroom tyrosinase, exhibiting an IC50 of 82.3 μM against the latter. This compound effectively reduces protein expression levels of RAS, HER2, phosphorylated BRAF, phosphorylated MEK, and phosphorylated ERK, leading to the induction of apoptosis and G0/G1 phase cell cycle arrest. It demonstrates notable cytotoxicity against colon cancer cells, making it a valuable tool for research focused on colon cancer and related signaling pathways. -
Leucine Aminopeptidase Inhibitor
L-Val-P is a selective inhibitor of leucine aminopeptidase (LAP), exhibiting a Ki value of 0.15 μM. This compound demonstrates significant potential in studies related to HIV infection, inflammatory processes, lens cataract formation, and various types of cancer. Its ability to modulate LAP activity makes L-Val-P a valuable tool for researchers investigating associated biological pathways and therapeutic targets. -
NEDD8 Activating Enzyme Inhibitor
ZM223 hydrochloride is a potent non-covalent inhibitor of the NEDD8 activating enzyme (NAE). This compound demonstrates significant anticancer activity, making it a valuable tool in cancer research. Its primary mechanism involves the disruption of NEDD8 conjugation processes, which can lead to altered protein stability and function, thereby influencing various cellular pathways. ZM223 hydrochloride is suitable for investigating the roles of NEDD8 modifications in tumor biology and therapeutic responses. -
NEP Inhibitor
Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. By competitively binding to NEP, Thiorphan inhibits its activity, thereby preventing the degradation of neuropeptides such as substance P and neurokinin A. This compound is particularly relevant in neonatal brain injury research, as it can elevate levels of these neuropeptides, activate NK1 and NK2 receptors, and mitigate excessive NMDA receptor activation, thus providing neuroprotection against excitotoxicity. Additionally, Thiorphan may play a role in studying respiratory diseases through its potential to inhibit NEP-mediated bronchoconstriction. -
NEP Inhibitor
Sacubitril sodium is a potent and orally active neprilysin (NEP) inhibitor, exhibiting an IC50 of 5 nM. By enhancing the activity of the natriuretic peptide (NP) system, it demonstrates significant antihypertensive effects. Sacubitril sodium is not only crucial in heart failure therapy but also serves as a valuable tool for research related to heart failure, hypertension, and COVID-19. -
Neprilysin Inhibitor
Phenylalanylalanine is a dipeptide that acts as a neprilysin inhibitor. This compound plays a significant role in modulating the metabolism of amyloid peptides, making it valuable in neurodegenerative disease research. It can be utilized to explore pathways related to proteolytic processing and may have implications in studies focused on Alzheimer's disease and other conditions linked to proteostasis. -
Neprilysin Inhibitor
Risotilide is a potent neprilysin inhibitor that effectively impedes enkephalinase B activity, with an IC50 value of 0.35 µM. Additionally, it demonstrates strong inhibition of enkephalinase A (IC50 = 0.02 µM) and aminopeptidase activity (IC50 = 13 µM). This comprehensive inhibition profile makes Risotilide a valuable reagent for studying enkephalin biodegradation and its implications in neurobiology and pain management research. -
Neprilysin Inhibitor
Mixanpril is a potent neprilysin inhibitor that significantly modulates insulin sensitivity. In studies using obese Zucker rats, Mixanpril demonstrates the ability to enhance insulin-mediated glucose disposal and effectively regulate femoral blood flow. Its distinct mechanism of action sets it apart from traditional ACE inhibitors, making it a valuable reagent for research in metabolic disorders and cardiovascular physiology. -
Neprilysin Inhibitor
Benproperine is a selective neprilysin inhibitor characterized by its unique N-acyl-L-prolyl-L-valine structure, featuring an α-isobutylsuccinic acid β-hydroxamic acid moiety. This compound exhibits significant biological activity by modulating the degradation of neuropeptides and other substrates of neprilysin. It is utilized in research applications aimed at investigating neurodegenerative diseases and the modulation of neuropeptide signaling pathways. -
NEP Inhibitor
SCH-39370 is a highly selective inhibitor of neutral metalloendopeptidase (NEP), exhibiting an IC50 value of 11.2 nM in rabbit kidney assays. This compound enhances the biological responses to atrial natriuretic factor and demonstrates significant antihypertensive effects in desoxycorticosterone acetate-sodium hypertensive rat models. SCH-39370 is valuable for research on cardiovascular function and the regulation of blood pressure through NEP inhibition. -
NEP Inhibitor
SCH-42354 is a potent, orally active inhibitor of neutral endopeptidase (NEP). This compound enhances the biological activity of atrial natriuretic peptide (ANP) by preventing its hydrolysis, which is crucial for regulating blood pressure. Inhibition studies demonstrate that SCH-42354 exhibits IC50 values of 8.3 nM for leu-enkephalin and 10.0 nM for atrial natriuretic factor (ANF). Its significant antihypertensive activity makes it a valuable tool for cardiovascular research and the study of peptide regulation in clinical applications. -
NEP Inhibitor
(Rac)-UK-414495 is a potent inhibitor of neutral endopeptidase (NEP), a key enzyme involved in peptide regulation. This compound has been shown to enhance cyclic AMP (cAMP) levels in the female genitalia, suggesting its potential role in modulating reproductive physiological processes. Its applicability in research may extend to studies focused on sex-based physiological response and NEP-related pathways. -
NEP Inhibitor
SCH 47896 is a potent and selective inhibitor of neprilysin (NEP), a metalloendopeptidase involved in the degradation of vasoactive peptides. This compound has demonstrated significant biological activity in research applications focused on cardiovascular diseases, particularly hypertension. By inhibiting NEP, SCH 47896 may provide insights into therapeutic strategies aimed at modulating cardiovascular function and improving patient outcomes. -
NEP Inhibitor
UK-447841 is a selective neprilysin (NEP) inhibitor. This compound has been identified for its potential role in modulating neuropeptide levels, making it applicable in studies related to female sexual arousal disorder. Research utilizing UK-447841 may provide insights into the therapeutic modulation of sexual function and related disorders. -
NEP Inhibitor
CGS25155 is a potent inhibitor of neutral endopeptidase 24.11 (NEP 24.11) with an IC50 of 3 nM. By inhibiting NEP, CGS25155 effectively slows the degradation of the cardiac hormone atrial natriuretic peptide (ANP), demonstrating antihypertensive effects in the DOCA-salt induced rat hypertension model. This compound is valuable for research in cardiovascular diseases and the study of peptide metabolism. -
Neprilysin Inhibitor
Dexecadotril is a selective neprilysin (NEP) inhibitor known for its potent biological activity. As a prodrug of the R-enantiomers of Thiorphan, Dexecadotril exhibits significant intestinal antisecretory properties. This reagent is valuable for research exploring the modulation of neuropeptide levels and potential therapeutic applications in conditions related to sodium and fluid balance. -
NEP Inhibitor
SCH-34826 is an orally active neutral metalloendopeptidase (NEP) inhibitor that effectively reduces ANF degradation, thereby enhancing its antihypertensive and diuretic effects. This compound is valuable for research applications in cardiovascular and renal disease studies, allowing for deeper insights into the modulation of fluid balance and blood pressure regulation. -
Neprilysin Inhibitor
NEP-In-1 is a potent inhibitor of neprilysin (NEP), exhibiting an IC50 value of 2 nM for dNEP. This compound effectively modulates the activity of NEP, an enzyme involved in the degradation of bioactive peptides. NEP-In-1 is valuable for research applications investigating neuropeptide signaling pathways and potential therapeutic strategies in neurodegenerative disorders. -
NEP Inhibitor
SCH 42495 is an orally active neutral endopeptidase (NEP) inhibitor that exerts antihypertensive effects. As the ethyl ester proagent of SCH 42354, it is utilized in research applications focused on cardiovascular diseases and the modulation of peptide metabolism. This compound serves as a valuable tool for investigating the role of NEP in various physiological and pathological processes. -
Neprilysin Inhibitor
SQ28603 is a selective inhibitor of neprilysin (NEP), an enzyme involved in the degradation of numerous peptides including atrial natriuretic peptide (ANP). By inhibiting NEP, SQ28603 can enhance the levels of ANP and potentially influence cardiovascular and renal function. This compound is valuable for research into heart failure, hypertension, and other conditions where atrial natriuretic peptide regulation is crucial. -
Neprilysin Inhibitor
NEP-IN-2 is a selective inhibitor of neprilysin, an enzyme involved in the degradation of bioactive peptides. This compound is critical for studying its role in the context of cardiovascular diseases such as atherosclerosis and restenosis. Researchers can utilize NEP-IN-2 to investigate the effects of neprilysin inhibition on cell proliferation and related signaling pathways in these disease models. -
Thrombin Inhibitor, Plasmin Inhibitor
PPACK TFA is a potent and selective irreversible inhibitor of thrombin, demonstrating significant anticoagulant properties. It serves as an alternative to lithium heparin for blood gas and whole blood electrolyte analyses. Additionally, PPACK TFA inhibits plasminogen activator (rt-PA), interfering with its binding to plasma protease inhibitors, and mitigates plasmin-induced alterations in endothelial permeability and morphology in bovine aortic endothelial cell monolayers. This compound is valuable for investigations related to thrombosis and endothelial function. -
uPA Inhibitor
APC8696 is a reversible inhibitor of urokinase-type plasminogen activator (uPA), exhibiting a nanomolar inhibitory constant (Ki) of 8 nM. This compound is valuable for investigating uPA-mediated processes in various biological systems. It is particularly relevant in cancer research and studies addressing tissue remodeling and inflammation. -
uPA Inhibitor
UCD74A hydrochloride is a 5-substituted amiloride analog that functions as a selective inhibitor of urokinase-type plasminogen activator (uPA), exhibiting an IC50 of 110 μM. This compound modulates plasminogen activation cascades associated with extracellular matrix remodeling, making it valuable in the study of tumor metastasis. UCD74A hydrochloride serves as a useful tool for researchers investigating the underlying mechanisms of cancer progression and tissue invasion. -
Thrombin Inhibitor
PPACK dihydrochloride is a potent and selective irreversible inhibitor of thrombin. It serves as an alternative anticoagulant to lithium heparin for blood gas and electrolyte analyses in whole blood. Additionally, PPACK dihydrochloride inhibits plasminogen activator (rt-PA), preventing its binding to plasma protease inhibitors. This compound also reduces plasmin-induced endothelial permeability and morphological changes in bovine aortic endothelial cell monolayers, making it suitable for investigations in thrombosis-related research. -
uPA Inhibitor
ZK824190 hydrochloride is a selective inhibitor of the urokinase plasminogen activator (uPA), demonstrating promising potential for the treatment of multiple sclerosis. With IC50 values of 237 nM for uPA, and higher IC50s of 1600 nM and 1850 nM for tissue plasminogen activator (tPA) and Plasmin, respectively, this compound can effectively modulate pathways associated with neuroinflammation. Its oral bioavailability also supports its applicability in in vivo studies aimed at elucidating the role of uPA in various disease models. -
uPA Substrate
Glutaryl-Gly-Arg-AMC is a specific peptide substrate for urokinase plasminogen activator (uPA). This compound is utilized in biochemical assays to measure uPA activity, making it a valuable tool in research focused on cancer metastasis and tissue remodeling processes. Its fluorescent properties allow for sensitive detection and quantification of uPA activity in various biological samples. -
uPA Inhibitor
Bicyclic UK18 is a competitive inhibitor of human urokinase-type plasminogen activator (uPA), demonstrating a Ki value of 53 nM. This compound plays a significant role in modulating fibrinolytic activity, making it useful in research related to thrombolysis and cancer metastasis. Its selective inhibition of uPA allows for detailed investigations into tissue remodeling and inflammatory processes. -
uPA inhibitor
CJ-463 is a potent and selective inhibitor of urokinase plasminogen activator (uPA). It exhibits significant antitumor activity, making it a valuable tool for cancer research. This compound is primarily utilized to investigate the role of uPA in tumor progression and metastasis, and may facilitate the development of novel therapeutic strategies targeting uPA-related pathways. -
Prolyl Endopeptidase Inhibitor
SUAM 1221 is a potent inhibitor of prolyl endopeptidase, an enzyme involved in the metabolism of neuroactive peptides. This compound exhibits significant biological activity by modulating peptide levels, making it a valuable tool in Alzheimer’s disease research. Its application facilitates the exploration of therapeutic strategies aimed at neurodegeneration and cognitive decline. -
Prolyl Endopeptidase (PEP) Substrate
Suc-Ala-Pro-pNA is a specific substrate for prolyl endopeptidase (PEP), designed to facilitate the measurement of PEP activity and stability. This peptide substrate releases para-nitroaniline (pNA) upon hydrolysis, enabling quantification in various experimental settings. It is valuable for biochemical assays and research focused on proteolytic enzyme activity, particularly in the context of neurodegenerative diseases and other related disorders. -
PREP Inhibitor
PREP inhibitor-1 is a potent prolyl oligopeptidase (PREP) inhibitor with an IC50 value of less than 1 nM. This compound selectively targets PREP, an enzyme involved in the modulation of neuropeptides and signaling pathways. Its high inhibitory activity makes it a valuable tool for research on neurodegenerative disorders and related neurological studies. -
Prolyl Endopeptidase (PREP)
Z-Gly-Pro-pNA is a substrate designed for the assessment of prolyl endopeptidase (PEP) activity. This compound can be utilized in assays to quantify PEP inhibition, offering insights into enzymatic function and regulation. It serves as an important tool for researchers investigating the role of PEP in various biological processes and potential therapeutic targets. -
Prolyl endopeptidase Inhibitor
Prolyl Endopeptidase Inhibitor 1 is a potent inhibitor of prolyl endopeptidase (PEP), with a Ki value of 15 nM. Its inhibitory action on PEP suggests potential applications in neurobiology, particularly for the investigation of cognitive processes. Additionally, Prolyl Endopeptidase Inhibitor 1 has demonstrated anti-amnesic effects, indicating its relevance in research on memory and cognitive disorders. -
Prolyl endopeptidase Inhibitor
Prolyl Endopeptidase Inhibitor 2 is a selective inhibitor of prolyl endopeptidase (PEP) with an IC50 value of 31.11 μM. This compound plays a crucial role in the modulation of proline-rich peptides and is relevant to research on neurodegenerative diseases. Its ability to inhibit PEP makes it a valuable tool for exploring therapeutic strategies in conditions where peptide degradation is implicated. -
PREP Inhibitor
Pramiracetam sulfate is a selective inhibitor of prolyl endopeptidase (PREP). It has been shown to enhance cognitive function, particularly following traumatic brain injury, making it a valuable tool in studying neurodegenerative diseases. This compound is suitable for research focused on the mechanisms of cognitive enhancement and potential therapeutic interventions for brain injuries and related disorders. -
POP Inhibitor
POP-IN-2 is a potent, covalent inhibitor of prolyl oligopeptidase (POP) with a Ki value of 6 nM. This reagent serves as a valuable tool for investigating the physiological roles of POP in neurodegenerative diseases and cancer, facilitating research into therapeutic strategies targeting these conditions. Its high specificity makes it suitable for detailed mechanistic studies in various biological contexts. -
PREP Inhibitor
Y-29794 is a selective, orally active inhibitor of non-peptide prolyl endopeptidase (PREP), demonstrating an IC50 of 3 nM and a Ki of 0.95 nM. It enhances the efficacy of thyrotropin-releasing hormone (TRH) on acetylcholine release in the rat hippocampus, indicating potential neuroprotective effects. Additionally, Y-29794 exhibits anticancer activity by inhibiting the IRS1-AKT-mTORC1 signaling pathway and shows the capability to penetrate the blood-brain barrier (BBB), making it valuable for various neurological and oncology research applications. -
Prolyl Endopeptidase Inhibitor
Z-Thioprolyl-Thiazolidine is a potent and selective inhibitor of prolyl endopeptidase, exhibiting a Ki value of 0.36 nM for bovine brain prolyl endopeptidase. This compound is valuable for research applications focused on peptide metabolism and neuropeptide regulation. Its specificity makes it an essential tool for studying the physiological and pathological roles of prolyl endopeptidase in various biological systems.
