Catalog No.
Product Name
Application
Product Information
Citations
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E3 Ligase Ligand-Linker Conjugates
(S,R,S)-AHPC-C3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, featuring the VHL ligand derived from VH032. This compound is designed for use in PROTAC (Proteolysis Targeting Chimera) technology, facilitating the targeted degradation of specific proteins. Its application in research includes the modulation of protein levels and the exploration of ubiquitin-proteasome system dynamics, making it a valuable tool for studies in cellular signaling and therapeutic development. -
E3 Ligase Ligand-Linker Conjugate
JQ-1 carboxylic acid-PEG3-C2-NH2 is an E3 ligase ligand-linker conjugate designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates targeted protein degradation by promoting the interaction between E3 ligases and specific substrates, thereby enabling the selective modulation of protein levels within cells. Its utility in creating PROTACs highlights its vital role in bivalent ligand design and drug development for therapeutic applications. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-AHPC-C2-PEG4-N3 is an E3 ligase ligand-linker conjugate designed for use in PROTAC technology, featuring the (S,R,S)-AHPC-based VHL ligand and a four-unit PEG linker. This reagent enables the synthesis of vRucaparib-TP4, a potent PARP1 degrader with a DC50 of 82 nM. Additionally, (S,R,S)-AHPC-C2-PEG4-N3 contains an azide group, facilitating click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAc) or strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Its applications include targeted protein degradation and advanced chemical biology research. -
Protein Ligand
VH 032 amide-alkylC5-azide is a functionalized ligand targeting the von-Hippel-Lindau (VHL) protein, specifically designed for PROTAC research and development. This compound features an E3 ligase ligand along with an alkyl linker, culminating in a terminal azide group suitable for conjugation to target protein ligands. Its unique structure facilitates the creation of innovative protein degradation systems, making it a valuable tool in chemical biology and therapeutic research. -
E3 Ligase Ligand-Linker Conjugate
Desamino lenalidomide-Pip hydrochloride is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN)-based ligand. This compound serves as a crucial building block for the synthesis of PROTACs (Proteolysis Targeting Chimeras), which facilitate target protein degradation via the ubiquitin-proteasome system. Its utility in chemical biology includes applications in targeted therapeutics and the study of protein degradation mechanisms. -
E3 Ligase Ligand-Linker Conjugate
Pomalidomide-C2-acid is an E3 ligase ligand-linker conjugate that combines the cereblon ligand derived from Pomalidomide with a specialized linker utilized in PROTAC technologies. This reagent is designed to facilitate targeted protein degradation through the ubiquitin-proteasome pathway. Its application in research allows for the development of innovative therapeutic strategies that manipulate protein dynamics in cellular systems. -
Ligands for E3 Ligase
Pomalidomide 4'-alkylC6-azide is a cereblon (CRBN) ligand that facilitates selective protein targeting via the recruitment of the CRBN protein. It serves as a key component in the development of PROTACs (Proteolysis Targeting Chimeras), enabling targeted degradation of specific proteins. This reagent is essential for research in targeted protein degradation and the modulation of cellular pathways critical for disease mechanisms. -
E3 Ligase Ligand-Linker Conjugate
Pomalidomide-propargyl is an E3 ligase ligand-linker conjugate designed for click chemistry applications. This compound features a potent E3 ligase ligand alongside a terminal alkyl group, facilitating efficient conjugation to target proteins. Pomalidomide-propargyl is an important tool for the development of Proteolysis Targeting Chimeras (PROTACs), enabling targeted protein degradation and advancing research in cancer biology and therapeutic discovery. -
E3 Ligase Ligand-Linker Conjugates
Pomalidomide-PEG3-C2-NH2 TFA is a synthetic ligand-linker conjugate designed for targeting the E3 ligase Cereblon. This compound consists of a Pomalidomide-derived cereblon ligand connected by a three-unit polyethylene glycol (PEG) linker. Pomalidomide-PEG3-C2-NH2 TFA is suitable for the synthesis of PROTACs (Proteolysis Targeting Chimeras), facilitating targeted degradation of specific proteins in various biological research applications. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride serves as an E3 ligase ligand-linker conjugate, featuring the (S,R,S)-AHPC VHL ligand integrated with a linker utilized in PROTAC technology. This compound facilitates targeted protein degradation, enhancing research applications in targeted therapy and chemical biology. Its utility in developing PROTACs makes it a valuable reagent for studying E3 ligase activity and pathway modulation in various biological contexts. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-AHPC-C4-NH2 dihydrochloride is a specialized E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This compound features the (S,R,S)-AHPC-based VHL ligand, facilitating the recruitment of E3 ligases for enhanced substrate degradation. It serves as an essential tool for researchers developing EED-targeted PROTACs, contributing to investigations in cellular regulation and therapeutic development. -
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride is an E3 ligase ligand-linker conjugate designed to facilitate protein degradation through the use of PROTAC technology. This compound features the VH032-derived VHL ligand, which selectively targets proteins for ubiquitination. Its alkyl linker enhances the formation of effective protein-degradative complexes, making it a valuable tool for research in targeted protein modulation and therapeutic development. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is an E3 ligase ligand-linker conjugate featuring a VHL ligand and a polyethylene glycol (PEG) linker. This compound facilitates targeted degradation of proteins through the PROTAC mechanism, enhancing the development of targeted therapeutics. Its applications include use in studies related to BRD4 degradation and other related research involving protein ubiquitination and modulation. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate featuring a VHL ligand combined with an optimized linker structure. This compound facilitates targeted protein degradation and is applicable in the development of PROTACs, such as DT2216, for studying protein regulation and interaction in cellular processes. Its role in enhancing E3 ligase activity makes it a valuable tool for drug discovery and therapeutic research. -
E3 Ligase Ligand-Linker Conjugates
Pomalidomide-5'-PEG8-C2-COOH is an E3 ligase ligand-linker conjugate that combines pomalidomide with an eight-unit polyethylene glycol linker. This compound is primarily utilized in the synthesis of proteolysis-targeting chimeras (PROTACs), facilitating selective degradation of target proteins. Its unique structure aids in enhancing the stability and bioavailability of PROTACs for targeted protein modulation in various biological research applications. -
E3 Ligase Ligand-Linker Conjugates
Pomalidomide-amino-PEG3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that combines the Pomalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG) linker. This compound is designed for use in PROTAC (Proteolysis Targeting Chimera) technology, facilitating targeted degradation of proteins by harnessing the ubiquitin-proteasome system. It serves as a valuable tool in chemical biology for investigating protein function and dynamics. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-Piperazine-Piperidine hydrochloride is an E3 ligase ligand-linker conjugate designed for use in targeted protein degradation applications. This compound combines a thalidomide-derived cereblon ligand with a piperazine-piperidine linker, enabling the development of PROTAC molecules. It plays a crucial role in modulating protein levels within cellular systems and may be employed for research into therapeutic strategies that harness the ubiquitin-proteasome pathway. -
Azide Compound
Pomalidomide 4'-alkylC4-azide is an azide-modified derivative of pomalidomide, designed to serve as a linker conjugate for E3 ligase ligands. This compound plays a crucial role in the synthesis of MIDI azide libraries and aids in advancing research on proteolysis-targeting chimeras (PROTAC) for targeted protein degradation. Its structure enhances the potential for molecular assembly and innovative therapeutic developments within chemical biology and pharmacology. -
E3 Ligase Ligand-Linker Conjugates
Pomalidomide-PEG3-C2-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that combines the Pomalidomide-derived cereblon ligand with a polyethylene glycol (PEG) linker. This compound facilitates targeted protein degradation through the PROTAC (proteolysis targeting chimera) technology by promoting the recruitment of E3 ubiquitin ligases. It is suitable for applications in investigations of protein turnover and cellular signaling pathways. -
Protein Ligand
VH032-C7-COOH is a functionalized ligand targeting the von-Hippel-Lindau (VHL) protein, primarily utilized in PROTAC (Proteolysis Targeting Chimera) research and development. This compound features an E3 ligase ligand along with an alkyl linker terminating in an amine group, facilitating the conjugation of target protein ligands. VH032-C7-COOH supports studies in targeted protein degradation, making it a valuable tool for advancing therapeutic strategies in cancer and other diseases. -
E3 Ligase Ligand-Linker Conjugate
Pomalidomide 4'-alkylC4-acid is an E3 ligase ligand-linker conjugate that incorporates a cereblon ligand, an alkylC4 chain, and a terminal acid. This compound facilitates the synthesis of PROTACs (proteolysis-targeting chimeras) by coupling with targeted protein ligands, enhancing the development of novel protein degradation strategies. Its biochemical properties make it a valuable tool for research in targeted therapeutics and protein modulation studies. -
E3 Ligase Ligand-Linker Conjugates
Pomalidomide-C4-NH2 hydrochloride is a potent E3 ligase ligand-linker conjugate featuring the Pomalidomide-derived cereblon ligand. This compound is designed for use in PROTAC (PROteolysis TArgeting Chimeras) technology, facilitating targeted protein degradation. Its unique structure enables effective modulation of protein levels within cells, making it a valuable tool for chemical biology and therapeutic research applications. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-CO-C2-acid is a functionalized von-Hippel-Lindau (VHL) protein ligand designed for use in E3 ligase ligand-linker conjugates. This compound enables the development of proteolysis-targeting chimeras (PROTACs) by facilitating the conjugation of target protein ligands. Its application enhances the targeted degradation of specific proteins, making it a valuable tool in the field of targeted protein modulation and therapeutic development. -
E3 Ligase Ligand-Linker Conjugate
Pomalidomide-PEG2-acetic acid is an E3 ligase ligand-linker conjugate designed for use in PROTAC synthesis. This compound facilitates the targeted degradation of specific proteins through the recruitment of E3 ligases, promoting the ubiquitination and subsequent proteasomal degradation of the desired targets. Its innovative structure supports advancements in the development of targeted protein degradation therapies and various cellular research applications. -
E3 Ubiquitin Ligase Ligand-Linker Conjugate
Thalidomide-O-C3-azide is a modified form of the cereblon (CRBN) inhibitor, Thalidomide, featuring an azide group that enables efficient insertion into click chemistry reactions. This compound undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, making it a valuable tool for the synthesis of E3 ubiquitin ligase ligand-linker conjugates. Thalidomide-O-C3-azide is primarily utilized in the development of PROTACs, facilitating targeted protein degradation studies and advancing research in cellular signaling and therapeutic applications. -
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-C5-NH2 dihydrochloride is an E3 ligase ligand-linker conjugate that features a VH032-derived VHL ligand coupled with a linker designed for estrogen-related receptor α (ERRα) PROTAC degradation. This compound facilitates targeted protein degradation through specific ubiquitination of ERRα, making it a valuable tool for research applications involving synthetic biology and therapeutic interventions in hormone-related pathways. Its design enhances the efficiency of targeted protein degradation processes, providing researchers with a potent means of modulating protein levels in cellular systems. -
E3 Ligase Ligand-Linker Conjugates
Pomalidomide-C3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate designed for use in PROTAC technology. This compound integrates the cereblon ligand derived from pomalidomide, facilitating targeted protein degradation. Its key applications include studying ubiquitin-proteasome pathways and developing targeted therapeutics for various diseases. -
E3 Ligase Ligand-Linker Conjugate
Lenalidomide-C3-NH2 is an E3 ligase ligand-linker conjugate that incorporates the Lenalidomide-based cereblon (CRBN) ligand. This compound is designed for use in the synthesis of PROTAC BET degrader-2. It enables targeted protein degradation through modulation of E3 ligase activity, making it a valuable tool in research involving protein homeostasis and degradation pathways. -
E3 Ligase Ligand-Linker Conjugates
Pomalidomide-amido-C1-Br is an E3 ligase ligand-linker conjugate that utilizes the cereblon ligand from Pomalidomide, designed for targeted protein degradation applications. This compound serves as a key component in the development of B-Raf PROTACs, specifically aiding in the construction of PROTAC B-Raf degrader 1, which exhibits notable anti-cancer activity. Researchers can leverage this conjugate to explore novel therapeutic strategies for malignancies driven by B-Raf mutations. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-AHPC-PEG5-Boc is an E3 ligase ligand-linker conjugate designed for targeted protein degradation. This compound combines the (S,R,S)-AHPC variant of the VHL ligand with a polyethylene glycol (PEG) linker to facilitate the efficient ubiquitination of Cdc20. Its primary application lies in the development of targeted therapeutic strategies aimed at modulating protein levels within cellular systems. This compound is ideal for use in drug discovery research focusing on E3 ligase-mediated degradation. -
E3 ligase ligand-Linker Conjugate
(S,R,S)-AHPC-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It features the (S,R,S)-AHPC-based VHL ligand along with a three-unit PEG linker that facilitates the targeted degradation of proteins. This compound is essential for studying E3 ligase activity and its applications in targeted protein modulation research. -
E3 Ligase Ligand-Linker Conjugates
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride is an E3 ligase ligand-linker conjugate featuring a cereblon (CRBN) ligand. This compound facilitates the design of PROTACs, such as MD-224, enabling targeted protein degradation through the modulation of ubiquitin-proteasome pathways. Additionally, it serves as a click chemistry reagent, containing an alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it a versatile tool for chemical biology research. -
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-C6-NH2 hydrochloride is an E3 ligase ligand-linker conjugate designed to facilitate targeted protein degradation through the VHL E3 ligase pathway. This compound incorporates a linkable moiety suitable for AKT PROTAC applications, promoting the selective degradation of target proteins. It serves as a valuable tool in drug discovery and development, particularly in studies exploring protein turnover and cellular signaling pathways. -
E3 Ligase Ligand-Linker Conjugates
Pomalidomide-PEG6-NH2 hydrochloride is a conjugate designed for E3 ligase-mediated ubiquitination, combining the cereblon ligand derived from Pomalidomide with a six-unit polyethylene glycol (PEG) linker. This compound facilitates the development of PROTAC (proteolysis-targeting chimeras) by enabling targeted protein degradation through the recruitment of E3 ligases. Its unique structure supports applications in drug discovery and targeted therapy research, particularly for modulating protein levels within cellular systems. -
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-C8-NH2 hydrochloride is an E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It features a VH032-derived VHL ligand, facilitating the targeted degradation of proteins through the ubiquitin-proteasome system. This compound is suited for applications in chemical biology and drug discovery, enabling researchers to investigate cellular pathways and protein interactions. -
Ligand-Linker Conjugate
(S,R,S)-AHPC-Me-C10-Br is a ligand-linker conjugate targeting E3 ligases. This compound features a VHL E3 ligase linker along with MS432, which is derived from the MEK1/2 inhibitor PD0325901. It is designed for applications in chemical biology and therapeutic research, particularly in the study of protein degradation pathways and targeted protein modulation. -
E3 Ligase Ligand-Linker Conjugates
Pomalidomide-PEG6-butyl iodide is a synthetic E3 ligase ligand-linker conjugate that features a Pomalidomide-derived cereblon ligand connected by a six-unit PEG linker. This compound is designed for use in PROTAC technology, facilitating targeted protein degradation by harnessing the ubiquitin-proteasome system. It serves as a valuable tool for researchers investigating protein regulation and degradation pathways, enhancing the development of therapeutic strategies against various diseases. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-AHPC-O-Ph-PEG1-NH2 is an E3 ligase ligand-linker conjugate, designed to incorporate a VHL ligand that targets the E3 ubiquitin ligase. This compound serves as a critical component in the development of PROTAC molecules, specifically utilized in the PROTAC EED degrader-1, which targets the EED protein with a pKD of 9.02. Its application is relevant in studies of targeted protein degradation and cellular signaling pathways, making it valuable for research in cancer and other diseases influenced by protein homeostasis. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-AHPC-amido-C5-acid functions as a ligand-linker conjugate targeting the VHL E3 ubiquitin ligase. This compound is designed to facilitate the development of PROTAC-based applications, effectively enabling the selective degradation of target proteins. It serves as a crucial building block in the synthesis of specialized compounds, exemplified by XY028-133. -
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride is an E3 ligase ligand-linker conjugate that combines the (S,R,S)-AHPC ligand with a two-unit polyethylene glycol (PEG) linker. This compound facilitates the design and synthesis of PROTACs (Proteolysis Targeting Chimeras) by promoting targeted protein degradation. It serves as a valuable tool in drug discovery and biological research focused on elucidating cellular mechanisms and developing novel therapeutic strategies. -
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-Me-C7 ester is an E3 ligase ligand-linker conjugate designed for the synthesis of BCL-XL PROTAC degraders. This compound facilitates targeted protein degradation by linking E3 ligases with substrates, thereby enabling the selective degradation of BCL-XL. It is particularly useful in studies focused on cancer therapeutics and biochemical pathways involving protein regulation. -
E3 Ligand-Linker Conjugate
Desamino lenalidomide-acetylene-C2-NH2 TFA is an E3 ligand-linker conjugate designed to target cereblon (CRBN) for targeted protein degradation applications. This compound serves as a crucial component in the synthesis of proteolysis-targeting chimeras (PROTACs), facilitating the selective degradation of specific proteins within cells. Its unique structure enables effective recruitment of the E3 ligase, thereby expanding research potential in therapeutic strategies aimed at modulating protein levels for various biological studies. -
E3 Ligase Ligand-Linker Conjugates
Glutarimide-Isoindolinone-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that targets cereblon, facilitating the development of PROTAC (Proteolysis Targeting Chimeras) technology. This compound enables the recruitment of E3 ligases for the selective degradation of specific proteins, making it invaluable for studying protein homeostasis and therapeutic intervention. Its application extends to research in targeted protein degradation and drug discovery, enhancing the efficacy of protein-targeted approaches. -
E3 Ligase Ligand-Linker Conjugate
Pomalidomide-PEG1-NH2 hydrochloride is an E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This compound incorporates pomalidomide, a well-characterized E3 ligase ligand, fused with a PEGylated crosslinker featuring a terminal amine. It facilitates the conjugation to carboxyl groups on target ligands, enhancing specificity and stability in biochemical assays and research involving the modulation of protein degradation pathways. -
E3 Ligase Ligand-Linker Conjugate
E3 Ligase Ligand-Linker Conjugate 157 is designed to target E3 ligases, facilitating the formation of proteolysis-targeting chimeras (PROTACs). This conjugate plays a crucial role in the synthesis of the PROTAC degrader KT-253, enabling selective degradation of target proteins. It is a valuable tool for researchers investigating targeted protein degradation and related therapeutic applications. -
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is an E3 ligase ligand-linker conjugate designed for utilization in PROTAC (Proteolysis Targeting Chimera) technology. This compound effectively engages E3 ubiquitin ligases, facilitating the selective degradation of target proteins through ubiquitination. It serves as a valuable tool in chemical biology for the development of novel therapeutics by enabling targeted protein modulation. -
E3 Ligase Ligand-Linker Conjugate
Pomalidomide-PEG6-C2-COOH is an E3 ligase ligand-linker conjugate that features the cereblon-binding Pomalidomide compound and a six-unit polyethylene glycol (PEG) linker. This reagent is designed for use in PROTAC (Proteolysis Targeting Chimera) technology, facilitating targeted protein degradation. It serves as a valuable tool for researchers exploring the modulation of E3 ligase activity and studying the implications of targeted protein degradation in various therapeutic contexts. -
CRBN Ligand
Pomalidomide-C6-COOH is a cereblon (CRBN) ligand derived from pomalidomide, designed for the specific recruitment of CRBN proteins. This compound serves as a vital building block for the development of PROTACs by enabling the conjugation of CRBN with various proteins via a linker. Its utility in targeted protein degradation makes it a valuable reagent for research applications in cellular signaling and therapeutic interventions. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-AHPC-C1-Br is a synthetic E3 ligase ligand-linker conjugate that utilizes the (S,R,S)-AHPC-based VHL ligand along with a specialized linker for targeted protein degradation applications. This compound is essential for research involving proteolysis-targeting chimeras (PROTACs), facilitating the selective degradation of specific proteins through the ubiquitin-proteasome system. Its design enhances the engagement and modulation of E3 ligases, contributing to advancements in therapeutic strategies targeting various diseases. -
E3 ligase ligand-linker conjugate
(S,R,S)-AHPC-PEG2-C4-Cl is an E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This compound features the (S,R,S)-AHPC derivative, coupled with a 13-atom-length halogen-linked alkyl/ether-based linker. Its ability to induce the degradation of target proteins, such as GFP-HaloTag7, makes it a valuable tool for researchers investigating E3 ligase-mediated pathways and protein homeostasis in cellular models.
