Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
tert-Butyl 20-bromoicosanoate serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound is integral in constructing bifunctional molecules that can target specific proteins for degradation via the ubiquitin-proteasome pathway. Its unique structure enhances the selectivity and efficacy of PROTACs in cellular studies and therapeutic applications, making it a valuable reagent for researchers in targeted protein degradation. -
PROTAC Linker
1-Boc-4-(4-Carboxybenzyl)piperazine is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of targeted protein degradation strategies, enabling researchers to selectively degrade specific proteins in biological research. Its unique structure enhances the binding efficiency of PROTACs, making it suitable for a wide range of applications in biochemistry and drug discovery. -
PROTAC Linker
6-tert-Butyl 2-methyl 6-azaspiro[3.4]octane-2,6-dicarboxylate is a specialized PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by promoting interactions between E3 ligases and specific proteins of interest. Its unique structural attributes enhance the efficiency of PROTAC development for studies in cellular mechanisms and therapeutic targeting. -
PROTAC Linker
N1,N4-Dimethylbutane-1,4-diamine is a versatile PROTAC linker utilized in the design and synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the conjugation of target proteins to E3 ligases, thereby promoting ubiquitination and subsequent proteasomal degradation. This compound plays a crucial role in targeted protein degradation research and drug discovery applications, allowing for the selective modulation of protein levels in various biological systems. -
PROTAC Linker
tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate serves as a key PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). Its structure enables efficient conjugation between an E3 ligase and a target protein, enhancing the selective degradation of specific proteins within cellular environments. This compound is instrumental in drug discovery and development research aimed at targeted protein degradation strategies. -
PROTAC Linker
Thalidomide-O-PEG4-acid is a PROTAC linker designed for targeted protein degradation applications. It features a reactive site for amine-containing moieties, enabling efficient conjugation in the presence of coupling agents such as EDC or HATU. This compound is crucial for the development of bifunctional molecules that facilitate the selective degradation of target proteins, supporting research in cancer, neurodegenerative diseases, and cellular regulation. -
PROTAC Linker
Methyl 2-[3-(aminomethyl)cyclobutyl]acetate hydrochloride serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins, making it valuable for targeted protein modulation in various research applications. Its structural properties contribute to the development of innovative therapeutic strategies in drug discovery and cancer research. -
PROTAC Linker
2-(2-((Tert-butyldimethylsilyl)oxy)ethoxy)acetic acid acts as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). Its structure enables efficient conjugation to target proteins, enhancing the selectivity and efficacy of targeted protein degradation strategies. This compound is valuable for researchers investigating protein regulation and the development of innovative therapeutic approaches in oncology and other fields. -
PROTAC Linker
Methyl 10-hydroxydecanoate is a versatile PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the specificity and efficacy of targeted protein degradation, making it an essential reagent for researchers focused on proteomics and drug development. Its unique structural properties allow for optimal integration in various PROTAC constructs, aiding in the exploration of novel therapeutic mechanisms. -
PROTAC Linker
Benzyl 5-hydroxypentanoate is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases, enabling targeted degradation of specific proteins within cellular pathways. Its application in drug discovery research supports the development of innovative therapeutics that selectively modulate protein levels. -
PROTAC Linker
Hex-3-enedinitrile is a versatile PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). Its unique chemical structure enhances the conjugation of targeting and E3 ligase components, promoting effective targeted protein degradation. This compound is instrumental in advancing research on targeted therapies and cellular protein regulation. -
PROTAC Linker
4-(Azetidin-3-yl)piperazin-2-one hydrochloride functions as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins through the ubiquitin-proteasome pathway, making it a valuable tool for studying protein function and regulation. Its application in the development of targeted protein degradation strategies supports advances in therapeutic interventions in various diseases. -
PROTAC Linker
4-Bromobutyl acetate serves as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in connecting target proteins with E3 ligases, thereby promoting targeted protein degradation. It is valuable for researchers investigating the modulation of protein levels in various biological pathways. -
PROTAC Linker
5-Aminopentanoic acid hydrochloride functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). By serving as a connecting unit between a target protein and an E3 ligase, it enhances the selective degradation of specific proteins within cells. This compound is valuable in chemical biology and drug discovery applications, particularly in studies focusing on targeted protein degradation mechanisms. -
PROTAC linker
endo-BCN-PEG3-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs by enabling targeted protein degradation. This compound features a bicyclononyne (BCN) group, which allows for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its applications extend to the development of advanced therapeutic modalities in chemical biology and drug discovery. -
PROTAC Linker
22-Bromodocosanoic acid serves as a versatile PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the development of targeted protein degradation strategies, enabling selective gene regulation and therapeutic development. Its chemical structure supports efficient conjugation, enhancing the stability and efficacy of resulting PROTACs for various biological applications in drug discovery and molecular biology research. -
PROTAC Linker
Boc-Piperazine-piperidine-2-F-Ph-CHO is a versatile PROTAC linker that facilitates the construction of targeted protein degradation molecules. This compound enables selective ubiquitination and subsequent degradation of specific proteins, making it vital in research areas focusing on proteostasis and therapeutic development. Its utilization in synthesizing bifunctional small molecules underscores its importance in advancing drug discovery and oncology research. -
PROTAC Linker
tert-Butyl N-methyl-N-[4-(methylamino)butyl]carbamate serves as a PROTAC linker, facilitating the development of targeted protein degradation therapeutics. This compound enables the formation of PROTACs by providing a flexible and stable connection between target proteins and E3 ligases. Its structural properties make it a valuable tool for researchers investigating innovative approaches to manipulate cellular protein levels in various biological studies. -
PROTAC Linker
tert-Butyl (3-aminopropyl)carbamate hydrochloride serves as a PROTAC (Proteolysis Targeting Chimeras) linker, facilitating the design and synthesis of novel PROTAC compounds. This reagent is essential for the development of targeted protein degradation strategies, enabling researchers to modulate protein levels in a selective manner. Its application in chemical biology provides valuable insights into protein function and regulation, making it a crucial tool for drug discovery and development. -
PROTAC Linker
Cbz-NH-C4-O-NH2 is a PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases for targeted protein degradation, enhancing the efficacy of therapeutic agents. Its use in PROTAC development supports various research applications in drug discovery and development, particularly in exploring targeted degradation mechanisms in cellular models. -
PROTAC Linker
p-Phenylenedipropionic acid serves as an effective PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances target specificity and stability of PROTACs, thereby enabling selective degradation of intracellular proteins. Its application is critical in drug discovery and development, particularly in the study of protein regulation and targeted protein degradation mechanisms. -
PROTAC Linker
Tert-butyl 4-((1r,4r)-4-aminocyclohexyl)piperazine-1-carboxylate is a functional linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the assembly of bifunctional molecules that can recruit E3 ligases to target proteins for ubiquitination and degradation. It is instrumental in advancing research in targeted protein degradation and therapeutic development. -
PROTAC Linker
Boc-C-PEG3-I is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the effective conjugation of target proteins with E3 ligases, enhancing the targeted degradation of intracellular proteins. Its unique structure allows for improved solubility and stability, making it suitable for diverse research applications in drug discovery and cancer therapy. -
PROTAC Linker
tert-Butyl 4-(azetidin-3-yl)piperidine-1-carboxylate is a specialized PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of bifunctional molecules that can selectively induce the degradation of target proteins, enabling targeted therapeutic interventions. Its role in PROTAC development makes it a valuable tool for researchers investigating protein regulation and degradation mechanisms in cellular processes. -
PROTAC Linker
3-Oxopropanoic acid serves as a key PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). This compound is integral in the construction of bifunctional molecules designed to induce targeted protein degradation. Its role is essential in various research applications focused on therapeutic development and the modulation of protein activity. -
PROTAC Linker
Boc-NH-(1-Methylbicyclo[2.2.2]octane)-amino is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances binding efficiency and stability between the target protein and E3 ligase, enabling controlled degradation of specific proteins within cellular systems. It is applicable in chemical biology and drug discovery research, particularly for studies focusing on targeted protein degradation. -
PROTAC Linker
Piperazin-C-benzoic acid dihydrochloride serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. This compound enhances the efficacy of PROTAC synthesis by providing a stable and versatile linker, essential for the selective modulation of protein function. Its application in chemical biology research supports the investigation of novel therapeutic strategies within drug discovery and proteomics. -
PROTAC Linker
4-Iodobutan-1-ol functions as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). Its structural properties promote efficient conjugation of target proteins with E3 ligases, enhancing the targeted degradation of unwanted proteins in cellular systems. This compound is valuable in research applications focused on targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
1,13-Dibromotridecane is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins through the modulation of the ubiquitin-proteasome system. It is particularly useful in the design of PROTACs for research applications in targeted protein degradation and therapeutic development. -
PROTAC Linker
Piperidine-4-carbaldehyde is a versatile PROTAC linker that plays a crucial role in enhancing protein degradation efficiency through targeted molecular interactions. Its structure allows for optimization of target protein affinity, making it an essential component in the development of novel PROTACs. This compound has demonstrated utility in the formulation of CDK2 PROTACs, facilitating advances in therapeutic strategies for targeted protein degradation. -
PROTAC Linker
BnO-PEG3-COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) molecules. This compound serves as a crucial component for the effective delivery of E3 ligase recruiting moieties to target proteins, facilitating their ubiquitination and subsequent degradation. BnO-PEG3-COOH is utilized in chemical biology research to investigate protein function and develop novel therapeutic strategies targeting protein misfolding and degradation pathways. -
PROTAC Linker
Octane-1,8-diamine-Glycolic acid is a versatile PROTAC linker designed for the synthesis of PROTAC molecules. Its primary application lies in cancer research, facilitating targeted protein degradation to investigate and modulate specific biological pathways. This compound plays a crucial role in the development of therapeutic strategies aimed at combating various malignancies. -
PROTAC Linker
Tert-butyl (5-aminopentyl)(methyl)carbamate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound effectively connects target proteins to E3 ligases, enabling targeted protein degradation and allowing researchers to investigate cellular processes, signaling pathways, and disease mechanisms. Its application is essential in the study of targeted therapeutics and in advancing drug discovery efforts. -
PROTAC Linker
m-PEG6-Hydrazide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of E3 ligase ligands to target proteins by providing a flexible and hydrophilic spacer. Its unique structure enhances the solubility and stability of PROTACs, making it an essential tool for studies focused on targeted protein degradation and drug discovery applications. -
PROTAC Linker
NHBoc-PEG3-CO-OBn is a PROTAC linker featuring a polyethylene glycol (PEG) moiety that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound is designed to enhance the solubility and stability of PROTACs while enabling efficient ubiquitination of target proteins. Its application in chemical research supports the exploration of targeted protein degradation and therapeutic interventions. -
PROTAC Linker
tert-Butyl 4-(4-(ethoxycarbonyl)phenoxy)piperidine-1-carboxylate serves as a key linker in the synthesis of PROTAC molecules, facilitating targeted protein degradation. Its structural features enable the effective conjugation of degrading agents to specific target proteins, enhancing selectivity and efficacy in research applications. This compound is valuable in the development of innovative therapeutic strategies aimed at modulating protein levels within cellular environments. -
PROTAC Linker
tert-Butyl (4-(aminooxy)butyl)carbamate is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in linking target proteins to E3 ubiquitin ligases, facilitating targeted protein degradation. Its application in research enhances the study of protein function and offers potential avenues for therapeutic intervention in various diseases. -
PROTAC Linker
3-(Hydroxymethyl)cyclobutanecarboxylic acid serves as a versatile PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and selectivity of PROTACs, making it a valuable tool for targeted protein degradation studies. Its unique structural properties promote efficient binding and ease of synthesis, contributing to advancements in research applications focused on protein modulation and therapeutic interventions. -
PROTAC Linker
Ethyl 7-aminoheptanoate functions as a PROTAC linker, facilitating the development of PROTAC compounds. This molecule is utilized in the synthesis of proteolysis-targeting chimeras, which promote targeted protein degradation. Its structural properties enable efficient conjugation to various biological entities, making it valuable for research in targeted protein modulation and therapeutic applications. -
PROTAC Linker
15-Aminopentadecanoic acid acts as a PROTAC linker, facilitating the design and synthesis of PROTACs. This compound features a long alkane chain with terminal carboxylic acid and amine groups, allowing for versatile reactivity. The amino group (NH2) readily engages with carboxylic acids, activated NHS esters, and carbonyls to form stable amide bonds, making it an essential reagent for targeted protein degradation research applications. -
PROTAC Linkers
Fmoc-Gly-Gly-Gly-NH-PEG4-C2-COOH is a PEG-derived linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of targeting ligands and E3 ligase recruiters, playing a pivotal role in the development of selective protein degradation strategies. Its unique structure enhances solubility and biological compatibility, making it suitable for various applications in drug discovery and research focused on targeted protein degradation mechanisms. -
PROTAC Linker
Methyl 11-aminoundecanoate hydrochloride serves as a PROTAC (Proteolysis Targeting Chimera) linker, facilitating the development of targeted protein degradation strategies. This compound plays a critical role in the synthesis of PROTACs, which are designed to selectively induce the degradation of specific proteins within cellular systems. Its utility in chemical biology and drug discovery enhances its relevance for researchers focused on innovative therapeutic approaches. -
PROTAC Linker
Tert-butyl 4-(2-prop-2-ynoxyethyl)piperazine-1-carboxylate is a specialized PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking them to E3 ligases, thereby modulating biological pathways. It is valuable in chemical biology and drug discovery for exploring targeted protein degradation mechanisms. -
PROTAC Linker
N-Methylpropane-1,3-diamine serves as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the design and development of targeted protein degradation strategies, enhancing the efficacy of therapeutic agents. Its utility in chemical biology makes it an essential tool for researchers exploring novel approaches in targeted therapy and drug discovery. -
PROTAC Linker
1-(2-(But-3-yn-1-yloxy)ethoxy)-6-chlorohexane serves as a versatile PROTAC linker, facilitating the construction of Proteolysis Targeting Chimeras (PROTACs). This compound enables the selective degradation of target proteins by engaging the ubiquitin-proteasome system. Its unique chemical structure enhances the efficacy of target engagement and modulation in various biochemical applications. Researchers can utilize this linker for advancing studies in targeted protein degradation and related therapeutic strategies. -
PROTAC Linker
6-(Benzyloxycarbonylamino)caproic acid functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of these bifunctional molecules, enhancing selectivity and efficacy in targeted protein degradation studies. Applications include research in cancer therapy, drug discovery, and the investigation of protein function through regulated degradation. -
PROTAC Linker
Ph-PEG9-NH2 is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the connection between E3 ligases and target proteins, enabling targeted protein degradation. Its application is crucial in research focused on protein regulation and therapeutic development in oncology and other disease areas. -
PROTAC Linker
Methyl 4-(((tert-butoxycarbonyl)amino)methyl)benzoate is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its structure facilitates the conjugation of target proteins to E3 ligases, enabling the selective degradation of unwanted proteins within cells. This compound is essential for researchers exploring novel therapeutic approaches in areas such as cancer and neurodegenerative diseases through targeted protein degradation. -
PROTAC Linker
NHBoc-PEG4-methyl acetate is a PROTAC linker designed for the synthesis of proteolysis targeting chimeras (PROTACs). Its flexible PEG4 spacer enhances solubility and bioavailability, facilitating targeted protein degradation. This compound is essential for researchers investigating novel therapeutic strategies involving targeted protein modulation through the use of PROTAC technology. -
PROTAC Linker
Ethyl 3-(piperidin-4-yl)propanoate serves as an efficient PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the ability to design and study targeted protein degradation pathways. Its application in chemical biology research supports advances in therapeutic development and targeted modulation of protein function.
