Fig. 1 · Structure
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(S,R,S)-AHPC-C3-NH2 hydrochloride
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-AHPC-C3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, featuring the VHL ligand derived from VH032. This compound is designed for use in PROTAC (Proteolysis Targeting Chimera) technology, facilitating the targeted degradation of specific proteins. Its application in research includes the modulation of protein levels and the exploration of ubiquitin-proteasome system dynamics, making it a valuable tool for studies in cellular signaling and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2940858-65-9 |
| Applications | E3 Ligase Ligand-Linker Conjugates |
| Formula | C26H38ClN5O4S |
| Molecular Weight | 552.13 |
| Synonyms | VH032-C3-NH2 hydrochloride |
| SMILES | NCCCC(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.