Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Tert-butyl 2-(2-aminoethyl)-2,8-diazaspiro[4.5]Decane-8-carboxylate is a versatile PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the connectivity between target proteins and E3 ubiquitin ligases, promoting targeted protein degradation. Its unique structure allows for the fine-tuning of PROTAC properties, making it a valuable tool in drug discovery and therapeutic development aimed at modulating protein levels within cellular systems. -
PROTAC Linker
1-Isothiocyanato-PEG3-azide is a versatile PEG-based PROTAC linker that facilitates the synthesis of proteolysis targeting chimeras (PROTACs). This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with entities possessing DBCO or BCN groups. Its utility in conjugation chemistry supports various applications in chemical biology and drug development. -
PROTAC Linker
2-(5-Bromopentyl)-1,3-dioxolane serves as a versatile PROTAC linker, enabling the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the modulation of protein degradation pathways, making it a valuable tool for research in targeted protein degradation and therapeutic development. Its unique structure supports the construction of effective PROTACs for various biological targets, advancing studies in cellular regulation and treatment strategies. -
PROTAC Linker
tert-Butyl ((3-oxocyclobutyl)methyl)carbamate serves as a specialized PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). It plays a crucial role in selective protein degradation strategies, enhancing the efficacy of targeted therapeutic interventions. This compound is instrumental in advancing research in drug discovery and the development of innovative treatment modalities. -
PROTAC Linker
HO-PEG6-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of different protein-targeting moieties, enabling the selective degradation of target proteins through the ubiquitin-proteasome pathway. Its incorporation into PROTACs allows for enhanced solubility and improved cellular uptake, making it a valuable tool in targeted protein degradation research. -
PROTAC Linker
Methyl 4-formylbicyclo[2.2.2]octane-1-carboxylate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficacy of targeted protein degradation by providing a scaffold for the assembly of target proteins and E3 ligase recognition elements. It is an essential reagent for researchers investigating novel therapeutic strategies utilizing the PROTAC technology. -
PROTAC Linker
tert-Butyl 4-(2-((methylsulfonyl)oxy)ethyl)piperidine-1-carboxylate is a PROTAC linker specifically designed for the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of undesirable proteins within cells. Its application is essential in drug discovery and development for addressing therapeutic targets that are challenging to inhibit with conventional small molecules. -
PROTAC Linker
Cis-Methyl 3-aminocyclobutanecarboxylate hydrochloride serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is crucial for creating targeted protein degradation molecules, enhancing the specificity and efficacy of therapeutic agents in biological research. Its role in the synthesis of innovative PROTACs makes it valuable for studies in targeted protein modulation and drug discovery. -
PROTAC Linker
3-(Hydroxyimino)-2,2,4,4-tetramethylcyclobutan-1-one is a versatile PROTAC linker utilized in the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins through the recruitment of E3 ubiquitin ligases. Its unique structure enhances bioconjugation capabilities, making it an essential tool for researchers investigating targeted protein degradation and therapeutic applications in various disease models. -
PROTAC Linkers
Fmoc-NH-PEG3-C2-NH2 is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the solubility and overall pharmacokinetic properties of PROTACs, facilitating their application in targeted protein degradation research. By incorporating this linker, researchers can develop more effective PROTACs for the modulation of specific protein targets, contributing to advancements in therapeutic strategies. -
PROTAC Linker
Ethyl 3-(4-bromophenyl)propanoate is a versatile PROTAC linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the selective degradation of target proteins by linking an E3 ligase ligand to a target protein ligand. This compound plays a crucial role in drug development, enabling researchers to explore novel approaches in targeted protein degradation. -
PROTAC Linker
N3-C5-O-C-Boc is a versatile PROTAC linker designed to facilitate the synthesis of targeted protein degraders. It plays a critical role in the development of PROTAC SARS-CoV-2 Mpro degrader-3, enabling precise modulation of protein levels in cell-based systems. This compound is suitable for research applications focusing on protein degradation pathways and therapeutic strategies against viral targets. -
PROTAC Linker
Cbz-NH-PEG5-CH2COOH is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, promoting selective degradation pathways. Its hydrophilic properties enhance solubility and improve pharmacokinetic profiles, making it a valuable tool in targeted protein degradation research and drug development. -
PROTAC Linker
Benzyl 5-Bromopentanoate is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for the conjugation of target proteins to ubiquitin ligases, enabling the degradation of specific proteins within a cellular context. Research applications include the study of targeted protein degradation mechanisms and the design of novel PROTACs for therapeutic interventions. -
PROTAC Linker
Benzyl 4-(4-((Tert-butoxycarbonyl)amino)butyl)piperazine-1-carboxylate functions as a PROTAC linker, facilitating the development of targeted protein degradation therapeutics. This compound is essential in the synthesis of PROTACs, enabling the selective modulation and degradation of specific proteins within cellular systems. Its utilization in research expands the exploration of protein dynamics and therapeutic interventions in various biological contexts. -
PROTAC Linkers
m-PEG16-NH2 is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides a flexible and biocompatible connection between the ligand and the E3 ligase, enhancing the efficiency and selectivity of target protein degradation. m-PEG16-NH2 is particularly valuable in research applications focused on targeted protein modulation and the development of novel therapeutic agents in the field of drug discovery. -
PROTAC Linker
BocNH-PEG2-CH2CH2NHMe is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances ligand efficiency and stability in targeted protein degradation applications. Its functional groups allow for effective conjugation and optimization of PROTACs, supporting research in cellular mechanisms and therapeutic development. -
PROTAC Linker
tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of heterobifunctional molecules that promote targeted protein degradation. Its unique structure enhances the interaction between E3 ubiquitin ligases and the degradation substrates, making it valuable for research applications in targeted therapy and drug discovery. -
PROTAC Linker
11-Cyanoundecanoic acid functions as a PROTAC linker, facilitating the construction of proteolysis-targeting chimera (PROTAC) molecules. This compound plays a critical role in the development of targeted protein degradation strategies, enabling researchers to modulate protein levels and investigate biological pathways. Its unique structure supports the design of innovative therapeutic agents in chemical biology and drug discovery applications. -
PROTAC Linker
2-(4-Chlorophenyl)ethanol serves as an effective PROTAC linker, facilitating the synthesis of proteolysis targeting chimeras (PROTACs). This compound enables precise ubiquitination and degradation of target proteins through the recruitment of E3 ligases. Its utility in chemical biology research supports the development of targeted protein degradation strategies, providing valuable insights into cellular processes and potential therapeutic applications. -
PROTAC Linker
2-((1-(tert-Butoxycarbonyl)azetidin-3-yl)oxy)acetic acid serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras. This compound enhances the selective degradation of target proteins by linking E3 ligases to protein of interest, enabling the study of protein function and potential therapeutic applications in targeted protein degradation research. Its utility makes it a valuable component for advancing PROTAC technology in chemical biology. -
PROTAC Linker
Tert-butyl 4-(4-(aminomethyl)benzyl)piperazine-1-carboxylate is a PROTAC linker designed to facilitate the synthesis of targeted protein degradation compounds. Its structure enables effective conjugation to protein-targeting motifs, enhancing the ability to selectively degrade specific proteins within cellular environments. This compound is relevant in the field of targeted therapeutics and plays a crucial role in the development of innovative treatments for various diseases. -
PROTAC Linker
2-Boc-2-Azaspiro[3.3]heptane-6-carbonitrile is a specialized PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in enhancing the selectivity and efficacy of targeted protein degradation. It is integral in research applications focusing on cellular signaling, cancer therapy, and the study of protein interactions and turnover. -
PROTAC Linker
Tert-butyl 4-(cyanomethyl)piperazine-1-carboxylate serves as a versatile PROTAC linker, facilitating the development of protein-targeting chimeras. Its unique chemical structure allows for improved stabilization and connectivity between the target protein and E3 ligase, enhancing targeted protein degradation. This compound is essential for researchers focused on therapeutic applications involving targeted protein modulation and cellular regulation. -
PROTAC Linker
Methyl 7-aminoheptanoate is a key linker used in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates targeted degradation of specific proteins within cellular environments, making it a valuable tool for researchers investigating protein functions and disease mechanisms. Its versatile structure supports the development of novel therapeutic candidates aimed at controlling protein levels in various biological contexts. -
PROTAC Linker
14-(Fmoc-amino)-tetradecanoic acid serves as a versatile PROTAC linker in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups, enabling efficient conjugation strategies. The Fmoc group can be removed under basic conditions to yield a free amine suitable for subsequent reactions. The terminal carboxylic acid can react with primary amines in the presence of coupling agents, such as EDC or HATU, facilitating the formation of stable amide bonds crucial for PROTAC development. -
PROTAC Linker
Methyl 3-(aminomethyl)bicyclo[1.1.1]pentane-1-carboxylate hydrochloride serves as a PROTAC linker, crucial for the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins within cells by linking an E3 ligase with the protein of interest. It is an important tool for researchers investigating targeted protein degradation mechanisms and developing therapeutic strategies in various diseases. -
PROTAC Linker
Tert-butyl 4-(2-Ethoxy-1,1-difluoro-2-oxoethyl)-5,6-dihydropyridine-1(2H)-carboxylate is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of bifunctional molecules that can selectively degrade target proteins through the ubiquitin-proteasome system. It is valuable in drug discovery and development, particularly in strategies targeting challenging disease-related proteins for therapeutic intervention. -
PROTAC Linker
tert-Butyl (azetidin-3-ylmethyl)(methyl)carbamate is a PROTAC linker designed to facilitate the development of protein degradation therapeutics through targeted protein degradation mechanisms. This compound plays a crucial role in the synthesis of PROTACs, enabling effective ubiquitination and subsequent proteasomal degradation of specific target proteins. Its application in chemical biology and pharmacology holds promise for advancing research in targeted therapies and protein regulation studies. -
PROTAC Linker
1,8-Nonadiyne is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the effective coupling of ligand pairs, enhancing target degradation through the ubiquitin-proteasome pathway. Its structural properties make it an excellent choice for researchers aiming to develop novel therapeutic strategies in targeted protein degradation. -
PROTAC Linker
tert-Butyl (4-chlorobutyl)carbamate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound is crucial for the synthesis of PROTACs, enabling targeted degradation of specific proteins through the ubiquitin-proteasome system. Its application in research allows for innovative approaches in cellular regulation and therapeutic strategies in cancer and other diseases. -
PROTAC Linker
Dimethyl bicyclo[1.1.1]pentane-1,3-dicarboxylate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the synthesis of PROTACs by providing a spatially appropriate linker that enables effective targeting and degradation of specific proteins. Its application is essential in chemical biology and therapeutic research focused on targeted protein degradation. -
PROTAC Linker
1,15-Dibromopentadecane serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the effective recruitment of E3 ligases to target proteins, allowing for targeted protein degradation. It is essential in studies focused on modulating cellular protein levels and investigating the therapeutic potential of PROTAC technology in various diseases. -
PROTAC Linker
4-(4-((tert-Butoxycarbonyl)amino)phenyl)butanoic acid serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent degradation of specific proteins within cellular systems. Its application is essential in the development of targeted protein degradation strategies for therapeutic intervention in various diseases. -
PROTAC Linker
6-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-hexanamine serves as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras. By efficiently connecting target proteins to E3 ubiquitin ligases, this compound enhances protein degradation pathways. It is crucial for researchers investigating targeted protein degradation and related therapeutic applications. -
PROTAC Linker
tert-Butyl N-[cis-3-(aminomethyl)cyclobutyl]carbamate serves as a PROTAC linker utilized in the synthesis of protein-targeting chimeras. This compound facilitates the selective degradation of target proteins by engaging the ubiquitin-proteasome system. Its effectiveness makes it a valuable tool in drug discovery and development, particularly in the context of targeted protein degradation strategies. -
PROTAC Linker
16-((tert-Butoxycarbonyl)amino)hexadecanoic acid is a PROTAC linker that facilitates targeted protein degradation by coupling to E3 ligases and protein targets. This compound plays a crucial role in the design and synthesis of PROTAC molecules, enabling the selective modulation of protein levels within cellular systems. Its application is vital in drug discovery and the development of innovative therapeutic strategies for various diseases. -
PROTAC Linker
Tert-butyl 2-(2-hydroxyethyl)-7-azaspiro[3.5]Nonane-7-carboxylate functions as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound exhibits the ability to enhance target protein degradation through the harnessing of the ubiquitin-proteasome system. Its application in PROTAC synthesis enables efficient modulation of protein levels for various research endeavors, including drug discovery and functional genomics. -
PROTAC Linker
18-Mercaptooctadecanoic acid serves as a PROTAC linker, facilitating the creation of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the development of targeted protein degradation strategies, allowing for the selective modulation of protein levels in various biological contexts. Its application is particularly valuable in drug discovery and development, aiding researchers in exploring therapeutic avenues in molecular biology and pharmacology. -
PROTAC Linker
CbzNH-(C5-O)2-C4-Boc is a PROTAC linker designed to facilitate targeted protein degradation. This compound is instrumental in synthesizing PROTACs such as CRBN-6-5-5-VHL, enabling the selective degradation of target proteins. Its structural properties enhance the development of innovative therapeutic strategies in chemical biology and medicinal research. -
PROTAC Linkers
m-PEG9-SH is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of E3 ligase ligands to target proteins, enhancing protein ubiquitination and subsequent degradation. m-PEG9-SH is essential for researchers investigating targeted protein degradation as a therapeutic strategy, enabling studies on protein function and regulation in various biological contexts. -
PROTAC Linker
Cis-3-[(Benzyloxy)methyl]cyclobutanol functions as a PROTAC linker, facilitating the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). Its structural properties enhance the connectivity between target proteins and E3 ligases, promoting targeted degradation pathways. This compound is crucial for researchers exploring targeted protein degradation mechanisms in various biological systems. -
PROTAC Linkers
Thiol-PEG5-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of specific proteins via the ubiquitin-proteasome system. Thiol-PEG5-alcohol is essential for researchers investigating protein regulation, cellular signaling pathways, and therapeutic interventions through targeted protein degradation. -
PROTAC Linker
TBS-PEG4-COOH is a versatile PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a polyethylene glycol (PEG) moiety that enhances solubility and improves cellular permeability. Its primary application lies in the targeted degradation of specific proteins, making it a valuable tool in drug discovery and development focused on targeted protein modulation. -
PROTAC Linker
Benzyl 2-(4-(bromomethyl)phenyl)acetate is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins via the ubiquitin-proteasome pathway. Its utility in small molecule drug discovery allows researchers to explore novel therapeutic strategies for various diseases by modulating protein levels. -
PROTAC Linker
Ethyl 11-bromoundecanoate is an effective PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by connecting E3 ligases to the substrates of interest, enhancing the therapeutic potential in targeted protein degradation research. Its unique structure allows for improved solubility and bioavailability in various biological applications. -
PROTAC Linker
Piperazin-C3-OH dihydrochloride is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of bifunctional molecules by linking target proteins to E3 ligases, enabling targeted protein degradation. Its application is crucial in drug development for investigating protein function and therapeutic interventions. -
PROTAC Linker
Boc-azetidine-piperazin dihydrochloride is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the selective degradation of target proteins by linking ligands that bind to the E3 ubiquitin ligase. This compound is essential in the development of targeted protein degradation strategies, enabling researchers to explore potential therapeutic applications in various disease models. -
PROTAC Linker
tert-Butyl (7-oxoheptyl)carbamate serves as a PROTAC linker, facilitating the development of protein degradation methods through targeted protein degradation targeting. Its structure enables effective conjugation with E3 ligases and protein targets, making it a valuable compound in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is essential for advancing research in targeted therapy and drug discovery. -
PROTAC Linker
4-(4-Piperidyl)-1-butanol is a versatile PROTAC linker that facilitates the development of targeted protein degradation compounds. This compound plays a crucial role in enhancing the stability and efficacy of PROTACs by serving as a molecular bridge between the target protein and an E3 ligase. Its application is key in advancing research in targeted therapy and the modulation of protein expression in various biological systems.
