Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. This compound enhances the selective degradation of specific proteins by linking an E3 ligase ligand to a protein of interest. It plays a critical role in chemical biology and therapeutic research, enabling novel approaches in drug discovery and development. -
PROTAC Linker
5-Bromopentan-1-amine hydrobromide is a versatile PROTAC linker designed for the synthesis of targeted protein degradation agents. Its structure facilitates the conjugation of target proteins and E3 ligase components, enabling the development of bifunctional molecules that promote selective ubiquitination and degradation. This reagent is essential for researchers investigating targeted therapy and novel drug discovery approaches in the fields of oncology and cell biology. -
PROTAC Linker
Decanedioic acid disodium acts as a PROTAC linker facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is critical in promoting targeted protein degradation through its ability to connect an E3 ligase and a protein of interest. Its application in drug development and research enhances studies focused on protein regulation and degradation pathways. -
PROTAC Linker
tert-Butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate is a specialized PROTAC linker designed to facilitate the development of targeted protein degradation applications. This compound enables the effective synthesis of PROTACs by serving as a versatile building block, promoting selective degradation of proteins within cellular contexts. Its unique structure supports research in protein homeostasis and therapeutic strategies targeting aberrant proteins in various diseases. -
PROTAC Linker
Methyl 4-piperazin-1-ylbenzoate serves as a versatile PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). This compound plays a critical role in connecting target proteins to E3 ligase, enabling targeted degradation of specific proteins within cells. It is essential for researchers focused on protein modulation, targeted therapy, and the advancement of novel drug delivery systems in chemical biology. -
PROTAC Linker
2-(Prop-2-yn-1-yloxy)acetic acid functions as a PROTAC linker, facilitating the design and assembly of PROTAC molecules. This compound plays a crucial role in the development of targeted protein degradation strategies, allowing for the selective modulation of protein activity in cellular systems. Its utility in chemical biology makes it a valuable tool for researchers exploring novel therapeutic interventions. -
PROTAC Linker
3-Benzyl-3,9-diazaspiro[5.5]undecane serves as a linker for PROTAC (Proteolysis Targeting Chimera) technology. This compound facilitates the design and synthesis of PROTACs, which are innovative molecules utilized for targeted protein degradation in cellular systems. Its unique structural features contribute to the effective engagement of E3 ubiquitin ligases, enabling researchers to explore novel therapeutic pathways in drug development and basic biological research. -
PROTAC Linker
tert-Butyl (4-hydroxybutyl)carbamate is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation by connecting E3 ligases to specific protein targets, enhancing the efficacy of therapeutic interventions. Its structural properties support the development of novel research tools in drug discovery and cellular regulation studies. -
PROTAC Linker
1,4-Bis(aminomethyl)benzene serves as a versatile PROTAC linker, integral to the design and synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the targeted degradation of specific proteins by linking an E3 ligase ligand to a protein of interest. Its application is essential in studies focused on protein homeostasis, cellular signaling, and therapeutic intervention in various diseases. -
PROTAC Linker
2-(4-Ethynylphenyl)acetonitrile acts as a versatile PROTAC linker, facilitating the development of PROTAC (PROteolysis TArgeting Chimeras) molecules. Its structural properties enhance the selective degradation of target proteins by the ubiquitin-proteasome system. This compound is valuable for research in targeted protein degradation, enabling studies in cancer biology and therapeutic development. -
PROTAC Linker
1-Boc-4-(Aminomethyl)piperidine hydrochloride functions as a PROTAC linker, facilitating the design and synthesis of targeted protein degraders. This compound is essential for creating bifunctional molecules that engage ligands for protein of interest and E3 ligases, thereby enabling targeted degradation pathways. It is widely used in research applications aimed at elucidating protein functions and developing novel therapeutic strategies through targeted protein modulation. -
PROTAC Linker
3-(benzyloxy)propanoic acid serves as a PROTAC linker, facilitating the construction of bifunctional small molecules that can induce targeted protein degradation. This compound enhances the stability and efficiency of PROTACs, making it valuable for research in the field of targeted therapeutics. Its incorporation into PROTAC design supports investigations into cellular mechanisms and treatment strategies for various diseases, including cancer. -
PROTAC Linker
tert-Butyl 2-(4-aminophenyl)acetate serves as a key PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins via the ubiquitin-proteasome system. Its significant role in the synthesis of PROTACs makes it valuable for research applications in targeted protein degradation and therapeutic development. -
PROTAC Linker
NHBoc-PEG3-I is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) compounds. This linker facilitates the conjugation of targeting ligands to E3 ligase recruiters, enhancing the efficacy of PROTACs in targeted protein degradation. Its application is critical in research focused on developing novel therapeutic strategies for diseases driven by abnormal protein expression. -
PROTAC Linker
1,14-Dibromotetradecane is a versatile PROTAC linker, designed to facilitate the synthesis of PROTACs by providing a robust connection between target proteins and E3 ligases. Its unique brominated structure enhances molecular interactions, aiding in the effective development of targeted protein degradation pathways. This compound is essential for researchers aiming to explore targeted therapies and functional proteomics in various biological systems. -
PROTAC Linker
Boc-12-Ado-OH serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain with a terminal carboxylic acid and Boc-protected amino groups, enabling it to react with primary amines in the presence of coupling reagents such as EDC or HATU to form stable amide linkages. The Boc group can be selectively deprotected under mild acidic conditions, yielding a free amine suitable for further chemical modifications and biological applications in targeted protein degradation studies. -
PROTAC Linker
Benzyl 4-(2-hydroxyethyl)piperidine-1-carboxylate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound is instrumental in the formation of targeted protein degradation systems, enhancing the specificity and efficacy of therapeutic agents. Its application in synthetic biology allows for the precise modulation of protein levels, contributing to innovative research in drug discovery and developmental biology. -
PROTAC Linker
Boc-Pip-cyclohexane-OH is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of covalent interactions between target proteins and E3 ligases, enabling targeted protein degradation. Its application is particularly valuable in drug discovery and development, advancing research in targeted therapies. -
PROTAC Linker
2-(2-Iodoethoxy)ethan-1-ol functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the targeted degradation of specific proteins by connecting an E3 ligase ligand to a target protein ligand. Its application in research enables the exploration of protein regulation and presents potential therapeutic strategies for various diseases. -
PROTAC Linker
Methyl 4-chloro-4-oxobutanoate is a PROTAC linker characterized by its ability to facilitate the recruitment of E3 ligases in targeted protein degradation. This compound serves as a crucial component in the synthesis of proteolysis-targeting chimeras (PROTACs), enhancing the specificity and efficacy of therapeutic applications. Methyl 4-chloro-4-oxobutanoate is instrumental in advancing research in drug discovery and protein regulation studies. -
PROTAC Linker
4-((tert-Butyldimethylsilyl)oxy)butan-1-amine serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the delivery of specific proteins for degradation, contributing to targeted therapeutic strategies. It is applicable in drug discovery and development, particularly in studies focused on protein modulation and the exploration of novel treatment pathways. -
PROTAC Linker
Rel-((1S,2R)-2-(Methoxycarbonyl)cyclopropane-1-carboxylic acid) serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and efficacy of PROTAC constructs by enabling selective target degradation. Its application in medicinal chemistry supports the advancement of innovative therapeutic strategies for various diseases through targeted protein modulation. -
PROTAC Linker
5-(Benzyloxy)pentan-1-ol is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound plays a key role in the synthesis of bifunctional molecules that can recruit E3 ligases to specific protein targets, enabling targeted protein degradation. Its use in research supports the exploration of targeted therapies and the study of protein regulation pathways. -
PROTAC Linker
4-(Benzyloxy)-4-oxobutanoic acid serves as a PROTAC linker, facilitating the assembly of PROTACs for targeted protein degradation. Its structural properties enable efficient conjugation to target proteins and E3 ligases, promoting selective ubiquitination and subsequent proteasomal degradation. This compound is valuable in chemical biology research, particularly for studies focused on modulating protein levels and exploring therapeutic strategies in drug discovery. -
PROTAC Linker
Boc-azetidine-cyclohexanamine is a PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in enhancing the cellular degradation of target proteins by facilitating the formation of active PROTAC complexes. Its application extends to various research areas, including targeted protein degradation and drug discovery, making it a valuable tool for studying protein interactions and functional genomics. -
PROTAC Linkers
PEG-bis-amine (Poly(ethylene glycol)-bis-amine, MW 2000) serves as a PEG-based linker for the synthesis of PROTACs, facilitating the targeted degradation of proteins. Its unique structure enhances solubility and biocompatibility, making it an essential component for constructing bifunctional molecules that promote the ubiquitin-proteasome system. This reagent is crucial for research applications involving targeted protein degradation and therapeutic discovery. -
PROTAC Linker
3-(4-Cyanophenyl)propanoic acid serves as an effective PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras. This compound plays a crucial role in the assembly of targeted protein degraders, enabling selective degradation of specific proteins within cellular systems. Its incorporation in research applications aids in the exploration of protein regulation and therapeutic intervention strategies. -
PROTAC Linker
4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylic acid functions as a PROTAC linker, essential for the construction of proteolysis-targeting chimeras (PROTACs). It facilitates the effective linkage of cellular proteins to E3 ubiquitin ligases, enabling targeted degradation of specific proteins in various biological studies. This compound is pivotal for research applications in targeted protein degradation and drug discovery. -
PROTAC Linker
tert-Butyl 2-bromo-7-azaspiro[3.5]nonane-7-carboxylate serves as a PROTAC linker, facilitating the development of PROTACs for targeted protein degradation. Its unique structure enables the formation of potent and selective bispecific degraders, allowing researchers to investigate the therapeutic potential of targeted protein downregulation. This compound is an essential tool for studies in targeted protein engineering and drug discovery applications. -
PROTAC Linker
tert-Butyl cis-4-(hydroxymethyl)cyclohexylcarbamate functions as a versatile PROTAC linker, facilitating the development of bifunctional molecules that induce proteolysis of target proteins. Its structural features enhance target specificity and enable effective recruitment of E3 ligases. This compound is instrumental in proteomics research, aiding in targeted protein degradation studies and drug discovery applications. -
PROTAC Linker
tert-Butyl 2-formyl-6-azaspiro[3.4]octane-6-carboxylate is a specialized linker for PROTAC (proteolysis targeting chimera) synthesis, facilitating the development of targeted protein degradation strategies. This compound enhances the binding of E3 ligases to the target proteins, promoting effective ubiquitination and subsequent proteasomal degradation. Its unique structure allows for increased specificity and efficiency in research applications focusing on targeted therapeutics and protein regulation studies. -
PROTAC Linker
tert-Butyl 4-(4-hydroxybutyl)piperidine-1-carboxylate functions as a PROTAC linker, facilitating the design and synthesis of PROTACs for targeted protein degradation. This compound plays a crucial role in the development of therapeutics aimed at selectively regulating protein levels in various biological pathways. Its application in research supports the advancement of innovative strategies in drug discovery and development. -
PROTAC Linker
tert-Butyl (4-aminobutyl)(methyl)carbamate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound effectively connects target proteins with E3 ligases, thereby enhancing the targeted degradation of specific proteins in various biological contexts. Its utility in research applications includes enabling studies in targeted protein degradation and drug discovery initiatives. -
PROTAC Linker
3-(Piperazin-1-yl)propanoic acid functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the efficient conjugation of target proteins to E3 ligases, enhancing targeted protein degradation. It is valuable in chemical biology studies focused on modulating protein levels for therapeutic applications. -
PROTAC Linker
tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in optimizing the pharmacological properties of PROTACs, enhancing their efficacy in selectively degrading target proteins. Its application in research supports advancements in targeted protein degradation strategies, offering potential therapeutic avenues in various diseases. -
PROTAC Linker
13-Bromotridecan-1-ol functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables selective degradation of target proteins, advancing research in targeted protein modulation and therapeutic applications. Its chemical structure allows for versatile use in creating effective PROTAC constructs for studying protein function and cellular pathways. -
PROTAC Linker
4-Ethynylcyclohexanone functions as a PROTAC linker, facilitating the construction of PROTAC molecules. It plays a crucial role in the targeted protein degradation pathway, enabling the design of selective degraders. This compound is utilized in research applications focused on protein regulation and therapeutic development through the use of PROTAC technology. -
PROTAC Linker
Monomethyl adipate serves as a versatile PROTAC linker, facilitating the synthesis of targeted protein degradation compounds. By providing a flexible and stable connection between the E3 ligase and the target protein, it enhances the efficacy of PROTAC technology. This compound is crucial for researchers looking to develop innovative therapeutic strategies through the regulation of protein levels in various biological contexts. -
PROTAC Linker
2-(Aminooxy)ethanamine dihydrochloride serves as a linker for the development of PROTACs (Proteolysis Targeting Chimeras), facilitating targeted protein degradation. This compound enables the synthesis of novel PROTACs by providing a unique connection between the ligand and the E3 ligase recruiter. Its application is crucial in studying protein function and regulation, with potential implications in therapeutic interventions for various diseases. -
PROTAC Linker
N-Boc-undecane-1,11-diamine is a PROTAC linker featuring a terminal amine and Boc-protected amino groups. This compound serves a pivotal role in the synthesis of PROTACs and facilitates various conjugation applications due to its reactive amine group, which can interact with carboxylic acids, activated NHS esters, and carbonyl compounds. The Boc group can be easily removed under mild acidic conditions to yield the free amine, enabling further functionalization and incorporation into complex biological systems. This reagent is essential for researchers focusing on targeted protein degradation and related bioconjugation strategies. -
PROTAC Linker
Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Cbz is a versatile PROTAC linker designed for targeted protein degradation applications. This compound facilitates the assembly of PROTAC molecules, enabling the selective degradation of target proteins. It is particularly useful in synthesizing complex structures, including those related to Deruxtecan research, thus contributing to studies in cancer therapy and biochemistry. -
PROTAC Linker
Undecane-1,11-diol serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the bioconjugation of Target proteins, allowing for the selective degradation of intracellular proteins. Its linear structure promotes efficient target engagement and contributes to the efficacy of targeted protein degradation strategies in research applications. -
PROTAC Linker
9-Decyn-1-ol serves as an alkyl/ether-based linker in the synthesis of PROTACs, facilitating the conjugation of various compounds. It is central to the generation of INY-03-041 by linking GDC-0068 and Lenalidomide, resulting in a potent pan-Akt degrader that selectively inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. Additionally, 9-Decyn-1-ol features an alkyne group suitable for click chemistry applications, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, which is invaluable in chemical biology research. -
PROTAC Linkers
Amino-PEG16-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves enhancing the solubility and stability of PROTACs while facilitating the selective degradation of target proteins through the ubiquitin-proteasome pathway. This reagent is essential for researchers developing novel approaches for targeted protein degradation in various biological studies and therapeutic applications. -
PROTAC Linkers
m-PEG24-Mal is a polyethylene glycol (PEG)-based linker designed for the synthesis of Protein Targeting Chimeras (PROTACs). This compound features a maleimide moiety that facilitates the conjugation of target proteins, enabling the effective degradation of specific proteins via the ubiquitin-proteasome pathway. Its application in the development of PROTACs supports research in targeted protein degradation and therapeutic strategies against various diseases. -
PROTAC Linker
Boc-PEG4-C2-NHS ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of E3 ligase ligands with target proteins, enhancing the selective degradation of specific proteins via the ubiquitin-proteasome system. Its application in PROTAC development makes it an essential reagent for researchers investigating targeted protein degradation and its therapeutic potential. -
PROTAC Linker
Bromo-PEG6-Boc is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the recruitment of E3 ligases, enhancing the degradation of specific target proteins. Its versatile chemistry supports the development of novel therapeutic agents in drug discovery and chemical biology research. -
PROTAC Linker
Carboxy-PEG4-phosphonic acid is a polyethylene glycol (PEG) based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the development of bifunctional molecules that can selectively target and degrade specific proteins within cells. Its application is crucial in advancing research on targeted protein degradation and the modulation of intracellular protein levels for therapeutic purposes. -
PROTAC Linker
Ald-Ph-PEG2-NH-Boc is a PEG-based linker designed specifically for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of PROTACs by providing a flexible and stable connection between the target protein and the E3 ligase. Its PEG moiety enhances solubility and improves pharmacokinetic properties, making it an essential tool for researchers investigating targeted protein degradation pathways and related therapeutic strategies. -
PROTAC Linker
tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate serves as a versatile linker in the synthesis of PROTAC (Proteolysis Targeting Chimeras) compounds. This compound is particularly utilized in the development of the PROTAC degrader TrimTAC1, facilitating targeted protein degradation through the recruitment of E3 ligases. Its application in chemical biology enables researchers to investigate protein function and modulation in various biological pathways.
