Fig. 1 · Structure
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4-(Benzyloxy)-4-oxobutanoic acid
PROTAC Linker
4-(Benzyloxy)-4-oxobutanoic acid serves as a PROTAC linker, facilitating the assembly of PROTACs for targeted protein degradation. Its structural properties enable efficient conjugation to target proteins and E3 ligases, promoting selective ubiquitination and subsequent proteasomal degradation. This compound is valuable in chemical biology research, particularly for studies focused on modulating protein levels and exploring therapeutic strategies in drug discovery.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 103-40-2 |
| Applications | PROTAC Linker |
| Formula | C11H12O4 |
| Molecular Weight | 208.21 |
| SMILES | O=C(O)CCC(=O)OCC=1C=CC=CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.