Fig. 1 · Structure
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NHBoc-PEG3-I
PROTAC Linker
NHBoc-PEG3-I is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) compounds. This linker facilitates the conjugation of targeting ligands to E3 ligase recruiters, enhancing the efficacy of PROTACs in targeted protein degradation. Its application is critical in research focused on developing novel therapeutic strategies for diseases driven by abnormal protein expression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1801273-41-5 |
| Applications | PROTAC Linker |
| Formula | C13H26INO5 |
| Molecular Weight | 403.26 |
| SMILES | O=C(OC(C)(C)C)NCCOCCOCCOCCI |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.