Fig. 1 · Structure
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PEG-bis-amine (MW 2000)
PROTAC Linkers
PEG-bis-amine (Poly(ethylene glycol)-bis-amine, MW 2000) serves as a PEG-based linker for the synthesis of PROTACs, facilitating the targeted degradation of proteins. Its unique structure enhances solubility and biocompatibility, making it an essential component for constructing bifunctional molecules that promote the ubiquitin-proteasome system. This reagent is crucial for research applications involving targeted protein degradation and therapeutic discovery.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 24991-53-5 |
| Applications | PROTAC Linkers |
| Formula | (C2H4O)nC4H12N2O |
| Molecular Weight | 2000(Average) |
| Synonyms | Poly(ethylene glycol)-bis-amine (MW 2000) |
| SMILES | NCCOCCOCCN.[n] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.