Fig. 1 · Structure
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Methyl 4-chloro-4-oxobutanoate
PROTAC Linker
Methyl 4-chloro-4-oxobutanoate is a PROTAC linker characterized by its ability to facilitate the recruitment of E3 ligases in targeted protein degradation. This compound serves as a crucial component in the synthesis of proteolysis-targeting chimeras (PROTACs), enhancing the specificity and efficacy of therapeutic applications. Methyl 4-chloro-4-oxobutanoate is instrumental in advancing research in drug discovery and protein regulation studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1490-25-1 |
| Applications | PROTAC Linker |
| Formula | C5H7ClO3 |
| Molecular Weight | 150.56 |
| SMILES | O=C(Cl)CCC(=O)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.