Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
N-Boc-serinol serves as an alkyl/ether-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. Its structural properties facilitate the formation of drug conjugates that enable targeted degradation of proteins. This compound is essential for researchers developing novel therapeutic strategies in targeted protein degradation and drug discovery. -
PROTAC Linker
3,6-Dioxaoctanedioic acid is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTACs. This compound facilitates the development of targeted protein degradation mechanisms by linking E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent proteasomal degradation. Its structural properties support effective binding and stability, making it a valuable reagent in research applications focused on targeted therapy and modalities in protein regulation. -
PROTAC Linker
Acid-PEG3-C2-Boc is a PEG- and alkyl/ether-based PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This linker enables the targeted degradation of proteins, including epidermal growth factor receptor (EGFR), and offers potential for the inhibition of mechanistic target of rapamycin (mTOR). Its versatile structure supports research applications in targeted protein degradation and therapeutic development in cancer research. -
PROTAC Linker
tert-Butyl (10-aminodecyl)carbamate functions as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs) and other conjugation applications. This compound features an alkane chain with a terminal amine and a Boc-protected amino group, enabling reactivity with carboxylic acids, activated NHS esters, and carbonyl compounds such as ketones and aldehydes. The Boc group can be deprotected under mild acidic conditions, yielding a free amine suitable for further coupling reactions in chemical research. -
PROTAC Linker
tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate serves as an effective PROTAC linker, facilitating target protein degradation through proteolysis-targeting chimeras (PROTACs). This compound is integral in the synthesis of specific PROTACs, such as ER Degrader-12 and AR Degrader-9, contributing to advancements in targeted protein degradation research and therapeutic development. Its unique structural properties make it suitable for manipulating protein interactions in various biological studies. -
PROTAC Linker
tert-Butyl but-3-yn-1-ylcarbamate serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins, making it a valuable reagent in drug discovery and protein research applications. Its unique structure allows for improved conjugation efficiency and stability in various biochemical contexts. -
PROTAC Linker
tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate functions as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). This compound is integral in the synthesis of innovative therapeutic agents aimed at selectively degrading target proteins. Its unique structural properties support the creation of effective PROTACs for a variety of research applications, including drug discovery and development in targeted protein degradation. -
PROTAC Linker
2-((tert-Butyldimethylsilyl)oxy)ethanol is a versatile PROTAC linker that enables the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation by linking an E3 ligase ligand and a target protein ligand, offering valuable applications in drug discovery and development. Its effectiveness in modifying the pharmacokinetic properties of PROTACs supports research in targeted therapy and cellular regulation. -
PROTAC Linker
tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate functions as a PROTAC linker, facilitating the conjugation of target proteins with E3 ligases. This compound is instrumental in the development of PROTACs for targeted protein degradation, enabling precise modulation of protein levels in various biological contexts. Its molecular structure supports efficient assembly of bifunctional molecules, contributing to advancements in therapeutic strategies for diseases driven by dysregulated protein expression. -
PROTAC Linker
3-Chloropropan-1-amine hydrochloride acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs, enabling the selective degradation of protein targets through the ubiquitin-proteasome system. Its application is significant in drug discovery and therapeutic research aimed at modulating protein function. -
PROTAC Linker
Hydroxy-PEG1-(CH2)2-Boc is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the assembly of PROTACs by enhancing solubility and biocompatibility. It is suitable for applications in medicinal chemistry and targeted protein degradation studies, contributing to advancements in therapeutic strategies. -
PROTAC Linkers
Bromo-PEG3-bromide is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bromo functionality that facilitates the selective recruitment of E3 ligases, enhancing targeted protein degradation. Its unique structure and properties make it an essential tool for researchers aiming to explore targeted protein modulation and degradation pathways in various biological contexts. -
PROTAC Linkers
Amino-PEG7-amine is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, promoting targeted protein degradation. It is valuable in drug discovery and biochemical studies aimed at modulating protein levels within cellular systems. -
PROTAC Linkers
Boc-NH-PEG3-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound enhances solubility and stability, making it suitable for the conjugation of ligand and E3 ligase components in drug development. Its role in chemical biology enables researchers to effectively study protein interactions and functions, contributing to advancements in therapeutic strategies. -
PROTAC Linkers
Nonaethylene glycol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the formation of PROTACs by conjugating target proteins to E3 ligases, enabling targeted protein degradation. Its utility in research applications includes the development of novel therapeutic strategies in cancer and other diseases by harnessing the power of targeted protein modulation. -
PROTAC Linker
1-Boc-4-carboxymethyl piperazine is a PROTAC linker that facilitates the development of targeted protein degraders. It plays a crucial role in the synthesis of PROTACs, enabling the selective degradation of specific proteins through the ubiquitin-proteasome pathway. This compound is particularly useful in research applications aimed at exploring new therapeutic strategies in various diseases, including cancer and other pathologies associated with dysregulated protein levels. -
PROTAC Linker
Propargyl-PEG4-amine is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. Featuring an alkyne group, it serves as a click chemistry reagent that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling the formation of stable conjugates with azide-containing molecules. This compound is essential for advancing research in drug development and targeted therapeutic strategies. -
PROTAC Linkers
Azido-PEG12-acid is a PEG-based PROTAC linker featuring an azide functional group, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is a key reagent for click chemistry applications, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules and strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN substrates. Its utility in PROTAC development supports the advancement of targeted protein degradation research. -
PROTAC Linker
3-Butyn-1-amine hydrochloride serves as a critical PROTAC linker, essential for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the development of bifunctional molecules that can selectively degrade target proteins, enhancing research in targeted protein degradation and therapeutic applications. Its structural properties facilitate the effective incorporation into a variety of PROTAC designs, making it a valuable tool for discovery and development in chemical biology and drug development. -
PROTAC Linker
tert-Butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by promoting the ubiquitin-proteasome system, enabling precise modulation of protein levels in various biological contexts. Its application in drug discovery and development makes it an essential tool for researchers investigating targeted protein degradation mechanisms. -
PROTAC Linker
tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate serves as an efficient PROTAC linker, facilitating the development of targeted protein degradation agents. This compound enhances the molecular interactions necessary for the effective recruitment of E3 ligases, thereby promoting the ubiquitination and subsequent degradation of specific target proteins. Its application is pivotal in research focused on developing therapeutic strategies that harness the power of the ubiquitin-proteasome system for selective protein manipulation. -
PROTAC Linker
14-Bromotetradecan-1-ol serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. This compound is instrumental in connecting a ligand for an E3 ubiquitin ligase with a protein of interest, enabling selective ubiquitination and subsequent degradation of specific proteins. Its key application lies in advancing research in therapeutic strategies that involve targeted modulation of protein levels. -
PROTAC Linker
8-(tert-Butoxy)-8-oxooctanoic acid serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras. Its structure allows for efficient conjugation to target proteins, enhancing the selective degradation of unwanted proteins within cells. This compound is instrumental in biochemical research applications focused on protein modulation and cellular pathway regulation. -
PROTAC Linker
Methyl 3-bromopropanoate is a key PROTAC linker that facilitates the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound plays a critical role in enabling targeted protein degradation, supporting research into therapeutic strategies for various diseases by modulating protein levels in cellular contexts. Its application in linking warheads to ligands makes it an essential reagent for developing innovative biopharmaceuticals. -
PROTAC Linker
Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in coupling target proteins to E3 ligases, enhancing the ubiquitination and subsequent degradation of specific proteins within cells. Its versatile application in synthetic biology assists in the design of innovative therapeutics aimed at selectively eliminating disease-associated proteins. -
PROTAC Linkers
m-PEG4-NHS ester is a PEG-based PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables selective ubiquitination and degradation of target proteins, providing a powerful tool for studying protein function and facilitating targeted protein degradation in therapeutic research. Its versatility in linking various targeting ligands makes it essential for advancing PROTAC technology. -
PROTAC Linker
Methyltetrazine-acid is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the efficient conjugation of ligands to E3 ligases, enhancing the targeted degradation of specific proteins. This compound is essential for researchers focusing on protein modulation and degradation in various cellular contexts. -
PROTAC Linker
m-PEG3-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of bifunctional molecules, enabling targeted protein degradation through the ubiquitin-proteasome pathway. Its unique properties enhance solubility and improve conjugation efficiency, making it an essential tool in chemical biology for drug discovery and development research. -
PROTAC Linkers
Amino-PEG4-Boc is a PEG-based PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). Its unique structure enhances cellular permeability and solubility, making it suitable for achieving targeted protein degradation in various biological systems. This compound is valuable in chemical biology and medicinal chemistry for developing innovative therapeutics that modulate protein levels with high specificity and efficiency. -
PROTAC Linker
tert-Butyl (5-bromopentyl)carbamate functions as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the recruitment of E3 ligases to target proteins, thereby promoting targeted protein degradation. Its application is crucial in drug development and studies focused on modulating protein levels for therapeutic purposes. -
PROTAC Linker
Thiol-PEG2-thiol is a polyethylene glycol (PEG) linker designed for use in the development of PROTAC (proteolysis-targeting chimera) compounds. This bifunctional reagent facilitates the synthesis of PROTACs by enabling the conjugation of target proteins to E3 ligase, thereby promoting targeted protein degradation. Its unique structure enhances solubility and biocompatibility, making it a valuable tool in chemical biology and drug development research. -
PROTAC Linker
tert-Butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the targeted degradation of specific proteins by promoting the ubiquitin-proteasome system. Its application is crucial in the study of protein regulation and offers potential in therapeutic research for various diseases, including cancer. -
PROTAC Linker
2-(Piperidin-4-yl)ethan-1-ol is a PROTAC linker utilized in the assembly of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of proteins by linking a target protein ligand to an E3 ligase ligand, allowing for controlled modulation of protein levels in cellular systems. Its application is instrumental in drug discovery and development, particularly in studying protein function and therapeutic interventions in various diseases. -
PROTAC Linkers
4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol functions as a versatile alkyl chain-based linker for PROTAC (proteolysis-targeting chimera) synthesis. This compound enables targeted protein degradation by connecting an E3 ligase with a target protein, facilitating the modulation of protein levels within a cellular context. It is suitable for research applications in the development of novel therapeutic agents and the study of protein homeostasis. -
PROTAC Linker
1-Boc-4-bromomethylpiperidine is a versatile PROTAC linker that plays a crucial role in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing targeted protein degradation. It is particularly useful in the development of novel therapeutics aimed at modulating cellular pathways through precise protein regulation. -
PROTAC Linker
tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate is a PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases and the targeted degradation of specific proteins, enabling researchers to investigate protein functions and cellular pathways. Its application is particularly relevant in drug discovery and development for therapeutic targets associated with various diseases. -
PROTAC Linker
1,3-Diiodopropane functions as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound is crucial for forming covalent links between target proteins and E3 ligases, enabling targeted protein degradation. Its applications are significant in chemical biology and drug discovery, particularly in the development of novel therapeutic agents aimed at selective protein modulation. -
PROTAC Linkers
NH2-PEG5-C6-Cl hydrochloride is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) compounds. This versatile linker facilitates targeted protein degradation by connecting the target protein and an E3 ligase, thereby promoting their interaction. It is essential for research applications involving PROTAC development, enabling investigations into protein regulation and therapeutic strategies for various diseases. -
PROTAC Linker
Azido-PEG2-azide is a PEG-based linker designed for use in the synthesis of PROTACs through its azide functional group. This compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules and can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) derivatives. Azido-PEG2-azide serves as an essential tool in the development of targeted protein degradation strategies, enhancing research in drug discovery and protein regulation studies. -
PROTAC Linkers
Amine-PEG4-Desthiobiotin is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of targeting ligands to ubiquitin ligase components, promoting targeted protein degradation. Its application in PROTAC development supports investigations into protein regulation and therapeutic interventions in various diseases. -
PROTAC Linker
(3R)-3-Pyrrolidinemethanol is a linker compound used in PROTAC (Proteolysis Targeting Chimeras) technology. It plays a crucial role in connecting target proteins to E3 ligases, facilitating the targeted degradation of specific proteins within the cellular context. This compound is essential for researchers exploring targeted protein degradation and the development of innovative therapeutic strategies. Its utility in creating effective PROTAC molecules makes it a valuable tool in chemical biology and drug discovery. -
PROTAC Linker
endo-BCN-PEG8-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its unique structure. As a click chemistry reagent, it features a BCN moiety capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound is essential for advancing targeted protein degradation research and enhancing the efficiency of PROTAC assembly in various biological applications. -
PROTAC Linkers
Azido-PEG8-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide functional group that enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-functionalized molecules. This compound is vital for researchers aiming to develop targeted protein degradation strategies in chemical biology applications. -
PROTAC Linker
Boc-NH-C4-acid is a PROTAC linker that serves as an alkyl/ether chemical moiety. It plays a crucial role in the synthesis of PROTAC1 and facilitates the targeted degradation of key components in the PRC2 complex, including EED, EZH2, and SUZ12. This linker is essential for research involving proteolysis-targeting chimeras, enabling advancements in targeted protein degradation studies. -
PROTAC Linker
Methyl-PEG3-bromide is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of protein ligands, enhancing targeted protein degradation. Its application in PROTAC development allows researchers to explore novel therapeutic strategies in targeted therapy and cellular regulation. -
PROTAC Linkers
Propargyl-PEG3-amine is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. With its ability to connect various bioactive components, Propargyl-PEG3-amine is essential for developing targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
Biotin-PEG2-NHS ester is a biotin-conjugated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. It serves as a valuable tool in chemical biology and drug discovery applications, providing insights into protein regulation and therapeutic development. -
PROTAC linker
Biotin-PEG5-azide is a PEG-based PROTAC linker designed for targeted protein degradation applications. This compound features an azide moiety that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, facilitating the conjugation of biomolecules containing alkyne, DBCO, or BCN groups. Its utility in synthesizing PROTACs makes it a valuable reagent for researchers investigating protein regulation and degradation pathways. -
PROTAC Linker
Bromo-PEG2-C2-Boc is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras). Its bromo group facilitates the conjugation of target proteins to E3 ligases, enhancing the selective degradation of specific proteins. This compound is essential for researchers developing PROTACs to investigate targeted protein degradation mechanisms and therapeutic applications. -
PROTAC Linker
tert-Butyl trans-4-aminocyclohexanecarboxylate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This reagent is essential for linking target proteins to E3 ligases, enabling the targeted degradation of intracellular proteins. Its application is pivotal in drug discovery and biochemical research, particularly in exploring therapeutic strategies for diseases where protein misregulation occurs.
