Fig. 1 · Structure
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Biotin-PEG5-azide
PROTAC linker
Biotin-PEG5-azide is a PEG-based PROTAC linker designed for targeted protein degradation applications. This compound features an azide moiety that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, facilitating the conjugation of biomolecules containing alkyne, DBCO, or BCN groups. Its utility in synthesizing PROTACs makes it a valuable reagent for researchers investigating protein regulation and degradation pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1163732-89-5 |
| Applications | PROTAC linker |
| Formula | C22H40N6O7S |
| Molecular Weight | 532.65 |
| SMILES | O=C(NCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.