Fig. 1 · Structure
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Mal-amido-PEG4-NHS ester
PROTAC Linker
Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in coupling target proteins to E3 ligases, enhancing the ubiquitination and subsequent degradation of specific proteins within cells. Its versatile application in synthetic biology assists in the design of innovative therapeutics aimed at selectively eliminating disease-associated proteins.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 756525-99-2 |
| Applications | PROTAC Linker |
| Formula | C22H31N3O11 |
| Molecular Weight | 513.50 |
| SMILES | O=C(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)ON2C(CCC2=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.