Fig. 1 · Structure
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3,6-Dioxaoctanedioic acid
PROTAC Linker
3,6-Dioxaoctanedioic acid is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTACs. This compound facilitates the development of targeted protein degradation mechanisms by linking E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent proteasomal degradation. Its structural properties support effective binding and stability, making it a valuable reagent in research applications focused on targeted therapy and modalities in protein regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 23243-68-7 |
| Applications | PROTAC Linker |
| Formula | C6H10O6 |
| Molecular Weight | 178.14 |
| SMILES | O=C(O)COCCOCC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.