Fig. 1 · Structure
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tert-Butyl 2,7-diazaspiro3.5nonane-2-carboxylate
PROTAC Linker
tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate serves as an effective PROTAC linker, facilitating target protein degradation through proteolysis-targeting chimeras (PROTACs). This compound is integral in the synthesis of specific PROTACs, such as ER Degrader-12 and AR Degrader-9, contributing to advancements in targeted protein degradation research and therapeutic development. Its unique structural properties make it suitable for manipulating protein interactions in various biological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 236406-55-6 |
| Applications | PROTAC Linker |
| Formula | C12H22N2O2 |
| Molecular Weight | 226.32 |
| SMILES | O=C(N1CC2(CCNCC2)C1)OC(C)(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.