Fig. 1 · Structure
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2-((tert-Butyldimethylsilyl)oxy)ethanol
PROTAC Linker
2-((tert-Butyldimethylsilyl)oxy)ethanol is a versatile PROTAC linker that enables the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation by linking an E3 ligase ligand and a target protein ligand, offering valuable applications in drug discovery and development. Its effectiveness in modifying the pharmacokinetic properties of PROTACs supports research in targeted therapy and cellular regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 102229-10-7 |
| Applications | PROTAC Linker |
| Formula | C8H20O2Si |
| Molecular Weight | 176.33 |
| SMILES | OCCO[Si](C)(C)C(C)(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.