Syk

Inhibitory Selectivity
Catalog No.Inhibitor Name SykOther
A10769R406 besylate
**
Flt3
A10770R406 (Tamatinib)
**
Flt3
A10771R788 Disodium
**
A12731PRT062607 HCl
****
FGR,MLK1,YES
A11926Fostamatinib
**
Adenosine A3 receptor,Adenosine transporter,Monoamine transporter
A16240MNS
*
p97,Src
A15524PRT-060318
****
A13884Entospletinib
***
A11320BAY-61-3606
***
A12162Piceatannol
Lyn,PKA,PKC
A11952P505-15 (PRT062607, BIIB057)
****
FGR, MLK1
A14161R112
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



13 Item(s)

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Catalog No. Product Name Application Product Information
A11320 SALE

BAY 61-3606

Syk Inhibitor
BAY 61-3606 is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
A15017

BAY 61-3606 dihydrochloride

Syk Inhibitor
BAY 61-3606 is a potent (Ki = 7.5 nM) and selective inhibitor of Syk kinase.
A13884 SALE

GS-9973

Syk inhibitor
GS-9973 is an oral inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity.
A16240

MNS

Src/Syk inhibitor
MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases.
A11952 SALE

P505-15 (PRT062607, BIIB057)

Syk inhibitor
P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.
A12162

Piceatannol

Syk Inhibitor
Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-??B activation and gene expression.
A15524

PRT-060318

Syk inhibitor
PRT-060318 is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment.
A12731 SALE

PRT062607 HCL

Syk Inhibitor
PRT2607, also known as PRT062607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.
A14161

R112

Syk inhibitor
R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells and also blocked leukotriene C4 production and all proinflammatory cytokines tested.
A10770 SALE

R406 (Tamatinib)

Syk Inhibitor
R406 is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling.
A10769 SALE

R406 besylate

Syk Inhibitor
R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.
A11926 SALE

R788 (Fostamatinib)

Syk inhibitor
R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling.
A10771

R935788 (Fostamatinib disodium, R788)

Syk Inhibitor
R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.

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