PRT062607 HCL

Catalog No.: A12731

Syk Inhibitor

PRT062607 HCL Chemical Structure

CAS NO. 1370261-97-4

PRT2607, also known as PRT062607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
25 mg
$300.00
50 mg
$480.00
10mM * 1mL in DMSO
$125.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PRT2607, also known as PRT062607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.
Targets
Target Value
SykIC50: 1nM
FGRIC50: 81nM
MLK1IC50: 88nM
YESIC50: 123nM
FLT3IC50: 139nM
PAK5IC50: 166nM
LynIC50: 192nM
c-SrcIC50: 244nM
LCKIC50: 249nM
In vitro (25°C) DMSO 86 mg/mL (200.04 mM)
Water 86 mg/mL (200.04 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.26 mL 116.3 mL 232.61 mL
0.5 mM 4.65 mL 23.26 mL 46.52 mL
1 mM 2.33 mL 11.63 mL 23.26 mL
5 mM 0.47 mL 2.33 mL 4.65 mL

*The above data is based on the productmolecular weight 429.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12731
Actions Inhibitor
M. Wt 429.91
Formula C19H24ClN9O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1370261-97-4
Synonyms P505-15, PRT2607, PRT-2607, PRT 2607, PRT-062607, PRT 062607, P505-15, BIIB057
SMILES C1CC[[email protected]]([[email protected]](C1)N)NC2=NC=C(C(=N2)NC3=CC=CC(=C3)N4N=CC=N4)C(=O)N.Cl

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