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Biological Activity
PRT2607, also known as PRT062607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.
Targets
| Target | Value |
|---|---|
| Syk | IC50: 1nM |
| FGR | IC50: 81nM |
| MLK1 | IC50: 88nM |
| YES | IC50: 123nM |
| FLT3 | IC50: 139nM |
| PAK5 | IC50: 166nM |
| Lyn | IC50: 192nM |
| c-Src | IC50: 244nM |
| LCK | IC50: 249nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.26 mL | 116.3 mL | 232.61 mL |
| 0.5 mM | 4.65 mL | 23.26 mL | 46.52 mL |
| 1 mM | 2.33 mL | 11.63 mL | 23.26 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.65 mL |
*The above data is based on the productmolecular weight 429.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12731 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1370261-97-4 |
| Formula | C19H24ClN9O |
| M. Wt | 429.91 |
| Purity | >98% |
| Synonyms | P505-15, PRT2607, PRT-2607, PRT 2607, PRT-062607, PRT 062607, P505-15, BIIB057 |
| SMILES | C1CC[[email protected]]([[email protected]](C1)N)NC2=NC=C(C(=N2)NC3=CC=CC(=C3)N4N=CC=N4)C(=O)N.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
United StatesAdooq Bioscience
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