FKBP12 PROTAC FM4 is a potent PROTAC degrader targeting FKBP12 with demonstrated efficacy in inducing degradation of the MTH1 protein. Its DC50 value ranges from 0.09 to 0.22 nM, effectively inhibiting global protein synthesis and promoting apoptosis in cervical cancer cells that express MTH1-E6 and FKBP12F36V-tagged SARS1. This compound is particularly relevant for research focused on HPV-positive cervical cancer, providing valuable insights into therapeutic strategies against this malignancy.
FKBP12 PROTAC FM4 is a potent PROTAC degrader targeting FKBP12 with demonstrated efficacy in inducing degradation of the MTH1 protein. Its DC50 value ranges from 0.09 to 0.22 nM, effectively inhibiting global protein synthesis and promoting apoptosis in cervical cancer cells that express MTH1-E6 and FKBP12F36V-tagged SARS1. This compound is particularly relevant for research focused on HPV-positive cervical cancer, providing valuable insights into therapeutic strategies against this malignancy.
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