Fig. 1 · Structure
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Efavirenz-d5
Stable Isotope
Efavirenz-d5 is a deuterium-labeled analog of Efavirenz, a potent inhibitor of HIV-1 reverse transcriptase, with a reported Ki of 2.93 nM and an IC95 of 1.5 nM for inhibiting HIV-1 replication. This stable isotope is particularly valuable for applications in metabolic studies and drug metabolism investigations. Additionally, Efavirenz-d5 contains an alkyne group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating various bioconjugation processes in chemical biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1132642-95-5 |
| Applications | Stable Isotope |
| Formula | C14H4D5ClF3NO2 |
| Molecular Weight | 320.71 |
| SMILES | C(#CC1(C(C1([2H])[2H])([2H])[2H])[2H])[C@@]2(C(F)(F)F)C=3C(NC(=O)O2)=CC=C(Cl)C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.