Fig. 1 · Structure
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15-Deoxy-Δ-12,14-prostaglandin J2-d4
Stable Isotope
15-Deoxy-Δ-12,14-prostaglandin J2-d4 is a deuterium-labeled derivative of 15-Deoxy-Δ-12,14-prostaglandin J2, a cyclopentenone prostaglandin and active metabolite of PGD2. This compound functions as a selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ) with an EC50 of 2 μM, and it acts as a covalent agonist of PPARδ. Additionally, 15-Deoxy-Δ-12,14-prostaglandin J2 has been shown to promote the differentiation of C3H10T1/2 fibroblasts into adipocytes, exhibiting an EC50 of 7 μM. It is suitable for various research applications in studying metabolic regulation and adipogenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1542166-82-4 |
| Applications | Stable Isotope |
| Formula | C20H24D4O3 |
| Molecular Weight | 320.46 |
| Synonyms | 15d-PGJ2-d4; 15-Deoxy-Δ12,14-PGJ2-d4 |
| SMILES | CCCCC/C=C/C=C1[C@H](C=CC\1=O)C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.