Fig. 1 · Structure
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Fmoc-leucine-d3
Stable Isotope
Fmoc-leucine-d3 is a deuterium-labeled version of Fmoc-leucine, a selective modulator of the peroxisome proliferator-activated receptor gamma (PPARγ). This compound activates PPARγ with reduced potency while exhibiting similar maximal efficacy compared to standard activators. Research has demonstrated that Fmoc-leucine-d3 enhances insulin sensitivity in both normal and diet-induced glucose-intolerant mice, as well as in diabetic db/db mice, all while maintaining lower adipogenic activity. Its stable isotope labeling makes it a valuable tool in metabolic studies and pharmacological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 538372-74-6 |
| Applications | Stable Isotope |
| Formula | C21H20D3NO4 |
| Molecular Weight | 356.43 |
| Synonyms | N-FMOC-leucine-d3; NPC 15199-d3; NSC 334290-d3 |
| SMILES | [2H]C([2H])([2H])C(C)C[C@@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.