Fig. 1 · Structure
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Binimetinib-d3
Stable Isotope
Binimetinib-d3 is a deuterated analog of Binimetinib, a selective inhibitor of MEK1/2. It demonstrates potent inhibition of MEK with an IC50 of 12 nM, making it a valuable tool for evaluating MEK signaling pathways. This stable isotope is useful in pharmacokinetic studies and metabolic profiling of Binimetinib in research applications involving cancer therapeutics and signal transduction investigations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2890696-59-8 |
| Applications | Stable Isotope |
| Formula | C17H12D3BrF2N4O3 |
| Molecular Weight | 444.25 |
| Synonyms | MEK162-d3; ARRY-162-d3; ARRY-438162-d3 |
| SMILES | O=C(C1=C(NC2=CC=C(Br)C=C2F)C(F)=C3C(N(C([2H])([2H])[2H])C=N3)=C1)NOCCO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.