Flumazenil

Catalog No.: A10397

Benzodiazepine antagonist

Flumazenil Chemical Structure

CAS NO. 78755-81-4

Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex. Flumazenil is a weak partial agonist in some animal models of activity, but has little or no agonist activity in humans.

Availability: In stock

Package Price Qty
50 mg
$90.00
100 mg
$150.00
200 mg
$250.00
500 mg
$450.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex. Flumazenil is a weak partial agonist in some animal models of activity, but has little or no agonist activity in humans.
Targets
GABAA receptor
In vitro DMSO 5 mg/mL (16.48 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.97 mL 164.85 mL 329.71 mL
0.5 mM 6.59 mL 32.97 mL 65.94 mL
1 mM 3.3 mL 16.49 mL 32.97 mL
5 mM 0.66 mL 3.3 mL 6.59 mL

*The above data is based on the productmolecular weight 303.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10397
Actions Antagonist
M. Wt 303.3
Formula C15H14FN3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 78755-81-4
Synonyms Ro 15-1788
SMILES CCOC(=O)c1ncn2c1CN(C)C(=O)c1c2ccc(c1)F

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