Biological Activity
Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex. Flumazenil is a weak partial agonist in some animal models of activity, but has little or no agonist activity in humans.
Targets
GABAA receptor | ||||
In vitro | DMSO | 4 mg/mL (13.18 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 32.97 mL | 164.85 mL | 329.71 mL |
0.5 mM | 6.59 mL | 32.97 mL | 65.94 mL |
1 mM | 3.3 mL | 16.49 mL | 32.97 mL |
5 mM | 0.66 mL | 3.3 mL | 6.59 mL |
*The above data is based on the productmolecular weight 303.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10397 |
---|---|
Actions | Antagonist |
CAS No. | 78755-81-4 |
Formula | C15H14FN3O3 |
M. Wt | 303.3 |
Purity | >98% |
Synonyms | Ro 15-1788 |
SMILES | CCOC(=O)c1ncn2c1CN(C)C(=O)c1c2ccc(c1)F |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy Flumazenil | Flumazenil Supplier | purchase | cost | manufacturer | order | distributor | buy 78755-81-4| 78755-81-4 Supplier | purchase 78755-81-4 | 78755-81-4 cost | 78755-81-4 manufacturer | order 78755-81-4 | 78755-81-4 distributor