Metabotropic glutamate receptors (mGluR)

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  1. Agonist (3)
  2. Antagonist (6)
  3. Modulator (7)


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Catalog No. Product Name Application Product Information
A16108

(S)-3,5-DHPG

mGluR agonist
(S)-3,5-DHPG is an agonist of the group I metabotropic glutamate receptors (mGluRs), binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 uM, respectively) but not ionotropic glutamate receptors.
A11181

ADX-47273

mGluR5 modulator

ADX-47273 is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5.

A11126

BINA

mGluR2 modulator
BINA is a selective positive allosteric modulator of mGlu2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2).
A15811

CBiPES HCl

mGlu2 receptor modulator
CBiPES hydrochloride is a selective positive allosteric modulator of the mGluR-2 with IC50 value of 98.2 nM
A15053

CPPHA

mGluR1 modulator
CPPHA is a selective positive allosteric modulator of mGluR5 receptor.
A11968

CTEP

-
CTEP is a highly potent, selective and orally bioavailable allosteric antagonist of mGlu5 receptor with an IC50 of 2.2 nM.
A15378

DL-AP3

mGluR1 antagonist
DL-AP3, a racemic preparation of D-AP3 and L-AP3, is an inhibitor of phosphoserine phosphatase and an antagonist of the metabotropic glutamate receptor (mGluR), blocking phosphoinositide turnover mediated by the mGluR.
A13123

LY 379268

mGlu2 receptor agonist
LY 379268 is a highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors.
A10544

LY2140023 (LY404039)

mGluR Agonist
LY-404039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation. Early human trials using a prodrug form of LY-404,039 called LY-214,0023 have also given encouraging results.
A12589

MPEP hydrochloride

mGlu5 receptor antagonist
MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors.
A15174

MTEP hydrochloride

mGlu5 antagonist
MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively.
A12705

PHCCC

mGluR antagonist
PHCCC is a group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM).
A13758

SIB 1757

mGluR antagonist
SIB 1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype.
A13759

SIB 1893

mGluR antagonist
SIB 1893 is a highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype.
A11754

VU 0357121

mGluR5 PAM
VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax.
A12467

VU 0361737

mGlu4 receptors modulator
VU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively).
A12664

VU 0364439

GluR modulator
VU 0364439 is a positive allosteric modulator (PAM) of mGlu4 receptors (EC50 = 19.8 nM in vitro for human mGlu4).
A15832

VU0364289

mGluR5 Modulator
VU0364289 is a novel N-aryl piperazine mGlu5 positive allosteric modulator.

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