Metabotropic glutamate receptors (mGluR)



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Catalog No. Product Name Application Product Information
A15053

CPPHA

mGluR1 modulator
CPPHA is a selective positive allosteric modulator of mGluR5 receptor.
A15174

MTEP hydrochloride

mGlu5 antagonist
MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively.
A15378

DL-AP3

mGluR1 antagonist
DL-AP3, a racemic preparation of D-AP3 and L-AP3, is an inhibitor of phosphoserine phosphatase and an antagonist of the metabotropic glutamate receptor (mGluR), blocking phosphoinositide turnover mediated by the mGluR.
A15811

CBiPES HCl

mGlu2 receptor modulator
CBiPES hydrochloride is a selective positive allosteric modulator of the mGluR-2 with IC50 value of 98.2 nM
A12467

VU 0361737

mGlu4 receptors modulator
VU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively).
A13236

MPEP HCl

mGlu5 receptor antagonist
MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 uM.
A12498 SALE

Perampanel

GluR antagonist
Perampanel is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical trials.
A14330

JNJ 42153605

mGluR-2 modulator
JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor.
A11484

LY341495

mGluR-2 antagonist
LY 341495 has been shown to be a highly potent and selective group II metabotropic glutamate receptor (mGluR-2) antagonist with Ki / IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGluR-2, mGluR-3, mGluR-8 , mGluR-7a, mGluR-1a, mGluR-5a and mGluR-4a.
A13854

A-841720

mGluR-1 antagonist
A 841720 is a potent, non-competitive mGluR-1 antagonist that displays 34-fold selectivity over mGluR-5 (IC50 values are 10 and 342 nM respectively).
A14006

Ibotenic Acid

NMDA& mGlu receptor agonist
Ibotenic acid is a neuroexcitatory amino acid originally isolated from Amanita species that functions as a NMDA and metabotropic glutamate receptor agonist.
A13485

Kainic acid monohydrate

Kainate receptor agonist
Kainate class of ionotropic glutamate receptor agonist. Has been shown to induce seizures and neurodegeneration in vivo and has also been used to induce experimental epilepsy in rodents and to examine excitation-induced neuronal apoptosis mechanisms.
A15189

Noopept

-
Noopept is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.
A15832

VU0364289

mGluR5 Modulator
VU0364289 is a novel N-aryl piperazine mGlu5 positive allosteric modulator.
A16108

(S)-3,5-DHPG

mGluR agonist
(S)-3,5-DHPG is an agonist of the group I metabotropic glutamate receptors (mGluRs), binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 uM, respectively) but not ionotropic glutamate receptors.
A13758 SALE

SIB 1757

mGluR antagonist
SIB 1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype.
A13759

SIB 1893

mGluR antagonist
SIB 1893 is a highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype.
A10006 SALE

(-)-Huperzine A

GluR inhibitor
(-)-Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata.
A11181

ADX-47273

mGluR5 modulator

ADX-47273 is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5.

A11126 SALE

BINA

mGluR2 modulator
BINA is a selective positive allosteric modulator of mGlu2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2).
A10544 SALE

LY2140023 (LY404039)

mGluR Agonist
LY-404039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation. Early human trials using a prodrug form of LY-404,039 called LY-214,0023 have also given encouraging results.
A11754

VU 0357121

mGluR5 PAM
VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax.
A11968 SALE

CTEP

-
CTEP is a highly potent, selective and orally bioavailable allosteric antagonist of mGlu5 receptor with an IC50 of 2.2 nM.
A12589

MPEP hydrochloride

mGlu5 receptor antagonist
MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors.
A12664

VU 0364439

GluR modulator
VU 0364439 is a positive allosteric modulator (PAM) of mGlu4 receptors (EC50 = 19.8 nM in vitro for human mGlu4).
A12705

PHCCC

mGluR antagonist
PHCCC is a group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM).
A13123

LY 379268

mGlu2 receptor agonist
LY 379268 is a highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors.
A12909

JNJ-40411813

mGluR2 PAM
JNJ-40411813 is a novel mGluR2 PAM.
A12139 SALE

VU 0364770

mGlu4 receptors modulator
VU 0364770 is a positive allosteric modulator at mGlu4 receptors with EC50 value of 290 nM in mGlu4-expressing HEK 293 cells.

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