MPEP

Catalog No.: A12589

mGlu5 receptor antagonist

MPEP

MPEP Chemical Structure

CAS NO. 96206-92-7

MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors.

Availability: In stock

Package Price Qty
10 mg
$50.00
25 mg
$100.00
50 mg
$160.00
100 mg
$280.00
10mM * 1mL in DMSO
$70.00
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Biological Activity

MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors.
Targets
mGluR5
36 nM
In vitro (25°C) DMSO 36 mg/mL (186.3 mM)
Water Insoluble
Ethanol 36 mg/mL (186.3 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 51.75 mL 258.73 mL 517.47 mL
0.5 mM 10.35 mL 51.75 mL 103.49 mL
1 mM 5.17 mL 25.87 mL 51.75 mL
5 mM 1.03 mL 5.17 mL 10.35 mL

*The above data is based on the productmolecular weight 193.249. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12589
Actions Antagonist
CAS No. 96206-92-7
Formula C14H11N
M. Wt 193.249
Purity >98%
SMILES CC1=CC=CC(=N1)C#CC2=CC=CC=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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