Protein Kinase C (PKC)

Inhibitory Selectivity
Catalog No.Inhibitor Name PKCPKCαPKCβPKCγPKCδPKCεPKCζPKCηPKCθPKCμOther
A10356Enzastaurin
**
***
*
*
A11554Sotrastaurin
****
****
****
****
****
****
A10864Staurosporine
****
****
**
*
*
****
c-Fgr,phosphorylase kinase,S6 kinase
A13790Go 6983
***
***
***
***
**
*
A13197Bisindolylmaleimide I
**
***
**
PDGFR
A13514Ro 31-8220 Mesylate
****
***
**
**
A12650Midostaurin
**
**
**
*
*
*
*
PPK,KDR,c-Syk
A12419Go6976
***
****
***
FLT3,JAK2
A10766Quercetin
Sirtuin,Src,PI3Kγ
A10616Myricitrin
A10196Chelerythrine chloride
*
A10261Bryostatin 1
***
A10286Daphnetin
*
EGFR, PKA
A12399Ruboxistaurin (LY333531)
*
****
*
*
**
A14871PKC (19-36)
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A12650

PKC 412 (Midostaurin)

PKC inhibitor
PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.
A16213

NSC305787

PKC inhibitor
NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 uM, 9.4 uM, 55 uM for PKC phosphorylation of recombinant ezrin, of moesin, and of radixin.
A16212

PKC-IN-1

PKC inhibitor
PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM; compound example H6 from patent WO 2008096260 A1.
A13043

(-)-Indolactam V

PKC activator
(-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm.
A14871

PKC (19-36)

PKC inhibitor
PKC (19-36), pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 uM).
A14616

12-O-tetradecanoyl phorbol-13-acetate

PKC activator
12-O-tetradecanoyl phorbol-13-acetate is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations.
A13514 SALE

Ro 31-8220

PKC inhibitor
Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.
A13790

GO6983

PKC inhibitor
GO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
A13094

alpha-Amyloid Precursor Protein Modulator

-
A13197 SALE

GF 109203X

PKC inhibitor
GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).
A12014 SALE

Verbascoside

PKC inhibitor
Potentially causes increased protein expression levels of PARP-1 and p53. Inhibitor of Protein Kinase C and shown to be effective against colitis.
A14307

NH125

eEF-2 inhibitor
NH125 is a selective eEF-2 kinase inhibitor.
A14336 SALE

Valrubicin

-
Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin.
A13679

Prostratin

PKC activator
Prostratin is a protein kinase C activator found in the bark of the mamala tree of Samoa, Homalanthus nutans.
A14882

[Ser25] Protein Kinase C (19-31)

-
Protein Kinase C (19-31), this peptide derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, it was used as protein kinase C substrate peptide for testing the protein kinase C activity.
A15557 SALE

TAS 301

PKC inhibitor
TAS 301 is an inhibitor of smooth muscle cell migration and proliferation.
A12399

Ruboxistaurin (LY333531)

PKC inhibitor
Ruboxistaurin (LY333531) is a potent, selective inhibitor of Protein Kinase C isozymes, PKC β I(IC50=4.7 nM) and PKC β II (IC50=5.9 nM).
A12419

Go 6976

PKC inhibitor
Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.
A10356 SALE

LY317615 (Enzastaurin)

PKCβ inhibitor
LY317615 (Enzastaurin) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC50= ~6 nM).
A10286 SALE

Daphnetin

EGFR, PKA,PKC inhibitor
Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.
A10766 SALE

Quercetin (Sophoretin)

MAO-B inhibitor
Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C.
A10196 SALE

Chelerythrine Chloride

PKC inhibitor

Chelerythrine affects translocation of PKC from cytosol to plasma membrane. Shown to prevent neurite growth. Induces apoptosis in a concentration- and schedule-dependent manner.

A10616

Myricitrin (Myricitrine)

-
Myricitrin is the 3-O-rhamnoside of myricetin. Myricitrin is used by several beetle species in their communication system.
A10261

Bryostatin 1

PKC inhibitor
Bryostatin 1 is a macrolactone isolated from the marine bryozoan, Bugula neritina, that modulates protein kinase C (PKC) activity. Bryostain 1 induces an initial rapid activation and autophosphorylation of PKC that results in the translocation of the PKC enzyme to the membrane.
A11554 SALE

Sotrastaurin (AEB071)

PKC inhibitor
Sotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.
A10864 SALE

Staurosporine

PKC inhibitor
Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.
A12963

Ingenol Mebutate (PEP005)

-
Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.

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