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Sotrastaurin (AEB071)

Catalog No.: A11554

PKC inhibitor

Sotrastaurin (AEB071)

Sotrastaurin (AEB071) Chemical Structure

CAS NO. 425637-18-9

Sotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.

Availability: In stock

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5 mg
10 mg
25 mg
50 mg
10mM * 1mL in DMSO
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Biological Activity

Sotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.
Target Value
PKCθki: 0.22nM
PKCβ1ki: 0.64nM
PKCαki: 0.95nM
PKCηki: 1.8nM
PKCδki: 2.1nM
PKCεki: 3.2nM
In vitro (25°C) DMSO 79 mg/mL (180.17 mM)
Water Insoluble
Ethanol 2 mg/mL (4.56 mM)
In vivo 2% DMSO+30% PEG 300+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.81 mL 114.03 mL 228.05 mL
0.5 mM 4.56 mL 22.81 mL 45.61 mL
1 mM 2.28 mL 11.4 mL 22.81 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11554
Actions Inhibitor
CAS No. 425637-18-9
Formula C25H22N6O2
M. Wt 438.5
Purity >98%
Synonyms AEB 071, AEB-071

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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