Sotrastaurin (AEB071)

Catalog No.: A11554

PKC inhibitor

Sotrastaurin (AEB071)

Sotrastaurin (AEB071) Chemical Structure

CAS NO. 425637-18-9

Sotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $120.00

Special Price $108.00

10 mg

Regular Price: $200.00

Special Price $180.00

25 mg

Regular Price: $380.00

Special Price $342.00

50 mg

Regular Price: $620.00

Special Price $558.00

10mM * 1mL in DMSO

Regular Price: $164.00

Special Price $147.60

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Sotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.
Targets
Target Value
PKCθki: 0.22nM
PKCβ1ki: 0.64nM
PKCαki: 0.95nM
PKCηki: 1.8nM
PKCδki: 2.1nM
PKCεki: 3.2nM
In vitro DMSO 87 mg/mL (198.41 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (4.56 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.81 mL 114.03 mL 228.05 mL
0.5 mM 4.56 mL 22.81 mL 45.61 mL
1 mM 2.28 mL 11.4 mL 22.81 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11554
Actions Inhibitor
M. Wt 438.5
Formula C25H22N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 425637-18-9
Synonyms AEB 071, AEB-071
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65

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