Ro 31-8220 mesylate

Catalog No.: A13514

PKC inhibitor

Ro 31-8220 mesylate

Ro 31-8220 mesylate Chemical Structure

CAS NO. 138489-18-6

Ro 31-8220 mesylate is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.

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Package Price Qty
10 mg
$120.00
25 mg
$250.00
50 mg
$420.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Dao-Lai Zhang, .et al. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851

Biological Activity

Ro 31-8220 mesylate is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.
Targets
PKCα PKCβ2 PKCβ1 PKCε PKCγ
5 nM14 nM24 nM24 nM27 nM
In vitro DMSO 85 mg/mL (153.52 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.06 mL 90.3 mL 180.6 mL
0.5 mM 3.61 mL 18.06 mL 36.12 mL
1 mM 1.81 mL 9.03 mL 18.06 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13514
Actions Inhibitor
CAS No. 138489-18-6
Formula C25H23N5O2SCH3SO3H
M. Wt 553.7
Purity >98%
Synonyms BIM IX, Bisindolylmaleimide IX (mesylate)
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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