GO6983

Catalog No.: A13790

PKC inhibitor

GO6983

GO6983 Chemical Structure

CAS NO. 133053-19-7

GO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.

Availability: In stock

Package Price Qty
10 mg
$150.00
25 mg
$300.00
50 mg
$480.00
10mM * 1mL in DMSO
$95.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
Targets
Target Value
PKCγIC50: 6nM
PKCαIC50: 7nM
PKCβIC50: 7nM
PKCδIC50: 10nM
PKCζIC50: 60nM
PKCμIC50: 20μM
In vitro (25°C) DMSO 59 mg/mL (133.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.6 mL 112.99 mL 225.98 mL
0.5 mM 4.52 mL 22.6 mL 45.2 mL
1 mM 2.26 mL 11.3 mL 22.6 mL
5 mM 0.45 mL 2.26 mL 4.52 mL

*The above data is based on the productmolecular weight 442.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13790
Actions Inhibitor
M. Wt 442.51
Formula C26H26N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 133053-19-7
Synonyms Go-6983, Go 6983
SMILES CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

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