LY317615 (Enzastaurin)

Catalog No.: A10356

PKCβ inhibitor

LY317615 (Enzastaurin)

LY317615 (Enzastaurin) Chemical Structure

CAS NO. 170364-57-5

LY317615 (Enzastaurin) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC50= ~6 nM).

Availability: In stock

Package Price Qty
10 mg
$40.00
50 mg
$120.00
100 mg
$200.00
200 mg
$350.00
10mM * 1mL in DMSO
$80.00
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Biological Activity

LY317615 (Enzastaurin) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC50= ~6 nM).
Targets
PKCβ (Cell-free assay) PKCα (Cell-free assay) PKCγ (Cell-free assay) PKCε (Cell-free assay)
6 nM39 nM83 nM110 nM
In vitro (25°C) DMSO 29 mg/mL (56.24 mM)
Water Insoluble
Ethanol Insoluble
In vivo 15% Captisol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.39 mL 96.97 mL 193.95 mL
0.5 mM 3.88 mL 19.39 mL 38.79 mL
1 mM 1.94 mL 9.7 mL 19.39 mL
5 mM 0.39 mL 1.94 mL 3.88 mL

*The above data is based on the productmolecular weight 515.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10356
Actions Inhibitor
CAS No. 170364-57-5
Formula C32H29N5O2
M. Wt 515.6
Solubility DMSO
Purity >98%
Synonyms LY-317615
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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