Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Practolol-d7 is the deuterated form of Practolol, a selective antagonist of the β1-adrenergic receptor. This stable isotope is invaluable for pharmacokinetic studies and metabolic research involving β1-adrenergic signaling pathways. Practolol-d7 is useful in the investigation of cardiac arrhythmias and potential therapeutic interventions targeting these conditions. -
Adrenergic Receptor Agonist
PF-610355 is a long-acting β2-adrenoreceptor agonist that exhibits potent activity with an EC50 of 0.26 nM. This compound is primarily utilized in research focusing on asthma and chronic obstructive pulmonary disease (COPD), providing insights into adrenergic signaling pathways and potential therapeutic interventions. Its mechanism of action makes it an essential tool for investigating respiratory therapeutic strategies. -
Adrenergic Receptor
Milveterol is a long-acting β(2)-adrenoceptor agonist that demonstrates high binding affinity. It exhibits potent bronchodilatory effects in vitro and a prolonged duration of action, as evidenced in a guinea pig bronchoprotection model. Milveterol's structural optimization enhances its binding potency, making it a valuable tool for research into respiratory diseases and related pharmacological applications. -
β(3)-adrenergic Receptor Agonist
L-796568 is a potent β(3)-adrenergic receptor agonist. This compound is primarily utilized in research focusing on obesity and metabolic disorders, facilitating studies on weight management and energy expenditure mechanisms. Its selective action on β(3)-adrenergic receptors makes it a valuable tool for investigating potential therapeutic strategies in obesity-related research. -
Adrenergic Receptor
Bedoradrine is a highly selective β2-adrenergic agonist that targets the adrenergic receptor, primarily utilized in the management of asthma and chronic obstructive pulmonary disease (COPD). It has demonstrated significant efficacy in suppressing acute asthma attacks, particularly in patients with stable moderate to severe asthma. Administered via intravenous infusion, Bedoradrine offers the potential for clinical benefits with a favorable safety profile, making it a suitable option for patients who are unable to use inhalers or nebulizers. -
Adrenergic Receptor Agonist
SKF 89748 is an α1-adrenergic receptor agonist known for its role in modulating appetite regulation by inhibiting food and water intake. In studies conducted on adult male rats, SKF 89748 demonstrated an effective dose (ED50) of 0.37 mg/kg for suppressing food consumption. This compound has applications in research focused on feeding behavior, adrenergic signaling pathways, and potential therapeutic strategies for appetite regulation. -
Alpha-2 Adrenoceptor Antagonist
Benalfocin hydrochloride is a selective antagonist of the alpha-2 adrenergic receptor. It is known to effectively reduce both blood pressure and heart rate, making it a valuable tool in cardiovascular research. Benalfocin can be utilized to investigate the physiological and pharmacological effects of alpha-2 adrenoceptor modulation in various experimental models. -
β2-adrenergic Receptor Agonist
Carbuterol is a selective β2-adrenergic receptor agonist that primarily targets bronchial smooth muscle to induce bronchodilation. It exhibits significant anti-allergic effects by inhibiting the immunologically induced release of histamine and slow-reacting substance of anaphylaxis (SRS-A), thus alleviating allergic reactions. Additionally, Carbuterol demonstrates mild β1-mediated cardiac stimulation, making it useful in research related to respiratory and immune disorders, including asthma and allergies. -
β2 Adrenergic Receptor Agonist
Meluadrine is a potent agonist of the β2 adrenergic receptor, which plays a crucial role in mediating physiological responses such as bronchodilation and vasodilation. As a key metabolite of Tulobuterol, Meluadrine exhibits significant biological activity that makes it valuable for research in respiratory conditions and other β2 receptor-related studies. Its application in pharmacological investigations may enhance the understanding of β2 adrenergic signaling pathways and therapeutic potentials. -
β2 Adrenergic Receptor Agonist
Meluadrine tartrate is a potent agonist of the β2 adrenergic receptor, known for its ability to stimulate adrenergic signaling pathways. This compound is primarily utilized in research applications focused on respiratory functions, cardiovascular modulation, and metabolic studies. Its efficacy in activating β2 receptors makes it a valuable tool for investigating the physiological and pharmacological roles of adrenergic signaling in various biological systems. -
β-adrenergic Receptor Antagonist
Toliprolol is a selective β1/β2-adrenergic receptor antagonist. This compound exhibits significant efficacy in modulating cardiovascular responses, making it valuable in the study of conditions such as angina pectoris and hypertension. Its mechanism of action is crucial for researchers exploring therapeutic interventions for various heart-related disorders. -
Stable Isotope
Cimbuterol-d9 is a deuterium-labeled derivative of Cimbuterol, functioning as a β-adrenergic agonist. This compound targets β-adrenergic receptors, exhibiting significant bronchodilator and tocolytic properties. Its stable isotope incorporation facilitates advanced pharmacokinetic studies and metabolic research applications, allowing for more precise investigations into the growth-promoting effects of β-adrenergic agonists. -
Adrenergic Receptor Agonist
GW-597901 is an adrenergic receptor agonist that exhibits significant bronchodilator activity. It demonstrates a stronger bronchodilator effect compared to salbutamol in human lung reperfusion models, albeit with a slightly slower onset of action. This compound is valuable for research applications related to respiratory therapies and the investigation of airway hyperresponsiveness. -
Beta 3 Adrenergic Receptor Agonist
L-749372 is a selective partial agonist of the beta 3 adrenergic receptor, exhibiting an EC50 of 3.6 nM. This compound is instrumental in studying the modulation of metabolic processes and thermogenesis associated with beta 3 adrenergic receptor activity. Its unique properties make it a valuable tool for exploring obesity, metabolic disorders, and related therapeutic avenues in chemical research. -
β-Agonist
Bromchlorbuterol hydrochloride is a potent beta-adrenergic agonist that primarily targets β-adrenergic receptors. It exhibits significant bronchodilator activity, making it useful in the study of pulmonary diseases, particularly asthma. This compound serves as a valuable tool for research focused on respiratory disorders and therapeutic interventions targeting the adrenergic signaling pathway. -
α-adrenergic receptor Antagonist
Azapetine is an α-adrenergic receptor antagonist that exhibits an IC50 of 0.205 μM for rat α1-adrenergic receptors and 1.3 μM for rat α2-adrenergic receptors. By inhibiting α1 and α2-adrenergic receptor-mediated contractions in blood vessels and vascular smooth muscle, Azapetine serves as a valuable tool for investigating peripheral vascular diseases. Its mechanism of action offers insights into the modulation of vascular tone and potential therapeutic approaches for related disorders. -
Dopamine Receptor Antagonist
Clebopride is an orally active dopamine receptor antagonist that primarily targets dopamine D2 receptors. This compound exhibits antiemetic and prokinetic properties, making it useful for investigating functional gastrointestinal disorders. Clebopride's ability to modulate dopamine signaling positions it as a valuable tool in pharmacological research relevant to gastrointestinal motility and related conditions. -
β-Agonist
Clencyclohexerol is a β-agonist that primarily targets beta-adrenergic receptors, promoting anabolic processes in biological systems. This compound exhibits significant growth-promoting activity, making it valuable in animal husbandry research and studies focused on metabolic regulation. Its application in veterinary sciences offers insights into muscle growth and overall performance enhancement in livestock. -
Adrenergic Receptor Agonist
Rec 15/2615 is a potent α(1)-adrenergic receptor agonist known to stimulate small cholangiocyte proliferation by activating calcium-dependent signaling pathways. This compound is utilized in research applications focusing on cholangiocyte biology and the underlying mechanisms of cell proliferation. Its specific target and action provide valuable insights into adrenergic signaling and its implications in liver physiology and disease. -
α2-Adrenergic Receptors Agonist
Methyldopa hydrochloride is an α2-adrenergic receptor agonist primarily utilized for its antihypertensive properties. As a prodrug, it is metabolized into α-methylepinephrine within the central nervous system, leading to a reduction in blood pressure through central sympatholytic mechanisms. This compound is commonly employed in cardiovascular research to study blood pressure regulation and sympathetic nervous system interactions. -
Adrenergic Receptor Antagonist
2-Methoxyidazoxan is an adrenergic receptor antagonist that primarily targets NEα-2 receptors. It has been shown to influence play behavior in F344 rats, indicating its potential role in modulating social interactions and behavior through adrenergic pathways. This compound is valuable for research applications focused on behavioral neuroscience and the mechanisms of neuropharmacology related to adrenergic signaling. -
α2 Agonist
Apraclonidine, an α2 adrenergic receptor agonist, is primarily utilized for its ability to reduce intraocular pressure (IOP) in individuals with glaucoma or ocular hypertension. This compound demonstrates selective agonist activity for α2 receptors, while exhibiting weak activity at α1 receptors. It is formulated as a topical ophthalmic solution for direct application to the eye, providing a targeted approach in managing elevated IOP. -
β2AR Activitor
CACPD2011a-0001278239 acts as a mixed agonist of the β2 adrenergic receptor (β2AR), exhibiting high-affinity binding to both wild-type and T164I β2AR variants. This compound is non-cytotoxic and non-mutagenic, making it an appropriate choice for studies related to asthma and respiratory disorders. Its unique profile allows for exploration of β2AR-related signaling pathways and therapeutic interventions. -
Stable Isotope
Phenylethanolamine A-d3 is a deuterium-labeled analogue of Phenylethanolamine A, which functions as a β-adrenergic agonist. This stable isotope is primarily utilized in metabolic studies and pharmacokinetic research to trace and quantify drug behavior in biological systems. It serves as a valuable tool for investigating the mechanisms of action and physiological effects associated with β-adrenergic receptor engagement. Additionally, Phenylethanolamine A is a byproduct of Ractopamine synthesis, highlighting its relevance in both metabolic and synthetic research. -
Adrenergic Receptor Inhibitor
Moprolol is a beta-adrenergic receptor inhibitor that primarily targets beta-adrenergic receptors to modulate cardiovascular responses. This compound is useful in research related to essential hypertension studies, enabling investigations into its effects on blood pressure regulation and heart rate modulation. Its properties make it a valuable tool for exploring the role of adrenergic signaling in hypertensive conditions. -
Adrenergic Receptor
NGD9002 free base is a selective antagonist of the corticotropin-releasing factor-1 (CRF-1) receptor, primarily targeting adrenergic receptors. It demonstrates significant inhibitory activity on CRF-induced colonic function stimulation, reducing fecal output responses with an IC50 value of 4.3 mg/kg. NGD9002 free base effectively blocks CRF-induced colonic secretory motility and mitigates acute water avoidance-induced defecation, while also preventing pain hypersensitivity reactions associated with repeated colonic distension. This compound is valuable for research into stress-related gastrointestinal disorders and the role of CRF in gut function. -
β3-Adrenergic Receptor Agonist
CP-114271 is a potent and selective agonist of the β3-adrenergic receptor, known for its ability to stimulate lipolysis and improve metabolic parameters. This compound demonstrates in vivo efficacy in rodent models, making it valuable for obesity research. CP-114271 is suitable for studies investigating metabolic disease mechanisms and potential therapeutic interventions related to obesity and related conditions. -
Sympathomimetic Agent
Pholedrine is an indirectly acting sympathomimetic amine that primarily targets adrenergic receptors. This compound exhibits significant cardiovascular activity, resulting in hypertensive effects, and induces mydriasis. Pholedrine is utilized as a topical eye drop for diagnostic purposes, particularly in the evaluation of Horner's syndrome, aiding in the localization of disruptions in the oculosympathetic pathway. -
α-adrenergic Receptor Blocker
Ethoxomane is an α-adrenergic receptor blocker that exerts antihypertensive effects by modulating adrenergic signaling. It elevates the hissing threshold induced by perifornical hypothalamic stimulation in feline models, providing insight into autonomic regulation. This compound is valuable for research applications focused on cardiovascular and cerebrovascular diseases, helping to elucidate mechanisms underlying hypertension and related disorders. -
β3-adrenergic Receptor Agonist
N-5984 is a potent and selective agonist of the β3-adrenergic receptor. This compound exhibits significant biological activity in promoting lipolysis and enhancing insulin sensitivity. Due to its targeted action, N-5984 is a valuable reagent for research into obesity management and diabetes treatment strategies. -
β1-Adrenergic Receptor Blocker
Bucindolol hydrochloride is a selective β1-adrenergic receptor blocker. It exhibits significant activity in reducing heart rate and preventing new-onset atrial fibrillation. This compound is primarily utilized in research related to heart failure and atrial fibrillation, aiding investigations into cardiovascular pharmacology and the mechanisms underlying cardiac rhythm disorders. -
Stable Isotope
Sotalol-d6 is a deuterium-labeled derivative of Sotalol, a non-selective β-adrenergic receptor antagonist. This compound exhibits potent antiarrhythmic activity, making it valuable for studying pediatric arrhythmias. Additionally, Sotalol-d6 inhibits β-receptors and potassium KCNH2 channels, highlighting its utility in the investigation of cardiac electrophysiology and as a potential antiepileptic agent. -
Stable Isotope
Betaxolol-d5 is a deuterated form of Betaxolol, a selective beta-1 adrenergic receptor antagonist. This stable isotope is primarily utilized in pharmacokinetic studies to investigate hypertension and glaucoma treatment mechanisms. The use of Betaxolol-d5 allows for enhanced studies on drug metabolism, distribution, and elimination in various biological contexts. -
β3-AR Agonist
L742791 is a selective β3-adrenergic receptor (β3-AR) agonist known to stimulate lipolysis. It promotes a lipolytic response in isolated nonhuman primate adipocytes, making it a valuable tool for research into metabolic regulation and obesity. This compound can be utilized in studies investigating the mechanisms of adipocyte function and energy expenditure. -
α2-Adrenergic Receptor Antagonist
Delequamine hydrochloride is a selective antagonist of α2-adrenergic receptors, exhibiting a pKi of 9.5 in rat cortex. This compound demonstrates greater than 1000-fold selectivity over 5-HT1A receptors and α1-adrenoceptors. Delequamine hydrochloride is primarily utilized in research relating to erectile dysfunction, providing insights into adrenergic signaling pathways and potential therapeutic targets. -
Adrenergic Receptor Antagonist
Bethanidine sulfate is a potent adrenergic receptor antagonist that functions primarily as an adrenergic neurone blocker. It inhibits the release of noradrenaline during nerve stimulation, resulting in sympathomimetic effects, particularly observed in animal models such as cats. This compound enhances smooth muscle responses to both adrenaline and noradrenaline and increases pressor responses to tyramine at lower doses. Additionally, while it briefly inhibits autonomic cholinergic mechanisms and can induce temporary neuromuscular paralysis at elevated doses, it does not lead to the depletion of pressor amine content in the iris, distinguishing it from other adrenergic blockers. -
Adrenergic Receptor Agonist
Metaproterenol is a selective β2-adrenergic receptor agonist, acting as a direct-acting sympathomimetic with an IC50 of 68 nM. This compound exhibits notable anti-inflammatory activity, making it relevant for research applications in respiratory conditions and bronchospasm relief. Its mechanism of action supports its use in studies related to asthma and chronic obstructive pulmonary disease (COPD) management. -
Adrenergic Receptor Control
(+)-ORM-10921 Free Base is a compound that predominantly interacts with adrenergic receptors, showcasing significant biological activity. It serves as a versatile reagent in the synthesis of pyrido[1,2-b]isoquinoline derivatives and is employed in multi-component reactions with alkynes and isoquinolinium ylides. This compound is pivotal for advancing synthetic organic chemistry by facilitating the formation of complex molecular architectures, thereby contributing to the development of novel compounds and research in related fields. -
Adrenergic Receptor Agonist
DL-Phenylephrine hydrochloride is a selective agonist of the alpha1-adrenergic receptor, known for its potent vasoconstrictive activity. This compound primarily mediates increases in vascular resistance and blood pressure, making it a valuable tool in cardiovascular research. Its application extends to studies involving hypertension, nasal decongestion, and various pharmacological investigations related to adrenergic signaling pathways. -
Adrenergic Agonist
Dipivefrin is a potent adrenergic agonist that acts as a pro-agent. It primarily functions by stimulating adrenergic receptors, leading to a reduction in intraocular pressure (IOP). This compound is utilized in research applications related to chronic open-angle glaucoma, where it helps to alleviate elevated IOP in affected patients. -
β2-Adrenergic Receptor Agonist
Levalbuterol, an (R)-enantiomer of Salbutamol, functions as a potent β2-adrenergic receptor agonist. It exhibits strong bronchodilation activity, making it particularly effective in the management of respiratory conditions such as chronic obstructive pulmonary disease (COPD). This compound serves as a valuable tool for researchers investigating bronchial responsiveness and airway inflammation. -
β2-adrenoceptor Agonist
Abediterol napadisylate is a long-acting β2-adrenoceptor agonist (LABA) that functions by selectively activating β2-adrenergic receptors to promote bronchodilation. This compound is primarily utilized in research related to asthma and chronic obstructive pulmonary disease (COPD), aiming to explore its therapeutic potential and mechanisms of action in respiratory conditions. -
β2-adrenergic Agonist
Clenproperol-d7 is a deuterium-labeled variant of Clenproperol, a selective β2-adrenergic agonist. It is utilized primarily in pharmacological research to study β2-adrenergic receptor signaling pathways. Its unique isotopic labeling enables tracing and quantification studies in metabolic processes, contributing to the understanding of β2-adrenergic activity in various biological contexts. -
α2 Adrenergic Receptor Agonist
Romifidine hydrochloride is an α2 adrenergic receptor agonist known for its sedative properties. This compound exhibits significant sedation effects in vivo, making it a valuable reagent for studies related to neuropharmacology and anesthesia. Its ability to modulate adrenergic signaling pathways provides insights into the regulatory mechanisms of sedation and analgesia, facilitating research in both clinical and preclinical settings. -
α1 Adrenergic Receptor Antagonist
Anisodamine hydrochloride is a potent α1 adrenergic receptor antagonist with anticholinergic properties. It has demonstrated efficacy in improving blood circulation in conditions such as septic shock. Additionally, Anisodamine hydrochloride exhibits pharmacological effects similar to those of atropine and scopolamine, including the inhibition of salivation, gastrointestinal motility, respiratory secretion, and urinary bladder contraction, making it valuable in various biochemical and physiological research applications. -
β2AR Antagonist
(2S,3S)-Zenidolol hydrochloride is a selective β2-adrenergic receptor (β2AR) antagonist, exhibiting pKi values of 7.51 for β1AR and 9.27 for β2AR. This compound is valuable in research related to cardiovascular conditions such as heart failure, ischemic heart disease, and hypertension, providing insights into β2AR modulation in these diseases. Its potency and specificity make it an essential tool for studying the role of adrenergic signaling in heart-related pathologies. -
Adrenergic Receptor
(R)-Bambuterol is a selective β2-adrenergic receptor agonist known for its anti-asthmatic properties. This compound has demonstrated efficacy in treating asthma and chronic obstructive pulmonary disease (COPD), offering the advantage of once-daily administration with minimal side effects. In preclinical studies, (R)-Bambuterol effectively alleviated disease severity in colitis models, significantly lowering inflammatory cytokines and macrophage infiltration in affected tissues. Additionally, it upregulates β2-adrenoceptor levels and suppresses the expression of pro-inflammatory markers such as IL-6 and IL-17 in colon tissue in a dose-dependent manner, making it a valuable tool for research in inflammatory diseases. -
β-adrenergic Receptor Agonist
L-665871 is an orally active β-adrenergic receptor agonist that enhances adrenergic signaling. It is primarily utilized in research applications related to growth promotion in swine. By stimulating β-adrenergic receptors, L-665871 can influence metabolic processes, making it a valuable tool for studying growth modulation and related physiological effects in livestock. -
Adrenergic Receptor Inhibitor
JNJ-7925476 hydrochloride is a triple monoamine uptake inhibitor that targets adrenergic receptors to modulate neurotransmitter availability. It demonstrates significant antidepressant activity, as evidenced by increased extracellular levels of serotonin, dopamine, and norepinephrine in the rat cerebral cortex. This compound is applicable in preclinical research to investigate the mechanisms underlying mood disorders and therapeutic interventions. Additionally, its rapid absorption and higher concentration in the brain support its potential for effective neurological studies. -
Dopamine D2/β2-adrenoceptor Agonist
Sibenadet is a dual agonist for dopamine D2 and β2-adrenoceptors, exhibiting selective activity at the β2-adrenoceptor. It has been shown to inhibit capsaicin-induced plasma protein extravasation in rat trachea, effectively suppressing edema resulting from sensory nerve fiber activation through β2-adrenoceptor activation. Sibenadet holds potential for advancing research into chronic obstructive pulmonary disease (COPD).
