CGP 12177 is a selective β-Adrenergic receptor (β-AR) ligand that primarily acts as a β3-AR agonist (Ki = 88 nM) while displaying antagonist activity at β1 (Ki = 0.9 nM) and β2-AR (Ki = 4 nM). Additionally, it demonstrates partial agonist characteristics for α1-AR in rat pulmonary artery tissues. This compound is relevant for research investigating the regulation of metabolic pathways, particularly the expression of ucp and leptin genes in adipose tissues, and holds potential applications in cardiovascular and metabolic disease studies.
CGP 12177 is a selective β-Adrenergic receptor (β-AR) ligand that primarily acts as a β3-AR agonist (Ki = 88 nM) while displaying antagonist activity at β1 (Ki = 0.9 nM) and β2-AR (Ki = 4 nM). Additionally, it demonstrates partial agonist characteristics for α1-AR in rat pulmonary artery tissues. This compound is relevant for research investigating the regulation of metabolic pathways, particularly the expression of ucp and leptin genes in adipose tissues, and holds potential applications in cardiovascular and metabolic disease studies.
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