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H2-005

Name: H2-005
Brand: Adooq Bioscience
SKU: A73309
Availability: OutOfStock

Cat. No. A73309 CAS 1060478-12-7

Endogenous Metabolite

H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2), effectively reducing triacylglycerol synthesis in both hepatocytes and preadipocytes. This compound demonstrates significant inhibition of triacylglycerol biosynthesis in HepG2 hepatocytes and 3T3-L1 preadipocytes. Additionally, H2-005 substantially inhibits lipid droplet formation in 3T3-L1 cells when used in conjunction with a DGAT1 inhibitor. This reagent is valuable for research related to DGAT2-mediated lipid metabolism and potential therapeutic strategies for metabolic disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1060478-12-7
Applications	Endogenous Metabolite
Formula	C₂₄H₃₂N₄O₄
Molecular Weight	440.54
SMILES	O=C(C1=C(C2=C(N1CCC(C)C)N=CC(NC(CC)CC)=C2)NC(C3=CC=CO3)=O)OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.