H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2), effectively reducing triacylglycerol synthesis in both hepatocytes and preadipocytes. This compound demonstrates significant inhibition of triacylglycerol biosynthesis in HepG2 hepatocytes and 3T3-L1 preadipocytes. Additionally, H2-005 substantially inhibits lipid droplet formation in 3T3-L1 cells when used in conjunction with a DGAT1 inhibitor. This reagent is valuable for research related to DGAT2-mediated lipid metabolism and potential therapeutic strategies for metabolic disorders.
H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2), effectively reducing triacylglycerol synthesis in both hepatocytes and preadipocytes. This compound demonstrates significant inhibition of triacylglycerol biosynthesis in HepG2 hepatocytes and 3T3-L1 preadipocytes. Additionally, H2-005 substantially inhibits lipid droplet formation in 3T3-L1 cells when used in conjunction with a DGAT1 inhibitor. This reagent is valuable for research related to DGAT2-mediated lipid metabolism and potential therapeutic strategies for metabolic disorders.
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