Fig. 1 · Structure
Documents & Downloads
Lu AF58801
Cat. No.
A73251
CAS
1531592-40-1
Endogenous Metabolite
Lu AF58801 is a selective positive allosteric modulator of the α7 nicotinic acetylcholine receptors, demonstrating potent oral bioavailability and effective brain penetration. This compound has been shown to enhance receptor activity and improve cognitive function in animal models, specifically in a novel object recognition task in mice subjected to subchronic exposure to fluchlorothiazol. Lu AF58801 serves as a valuable tool for investigating the role of α7 nicotinic receptors in cognitive processes and related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1531592-40-1 |
| Applications | Endogenous Metabolite |
| Formula | C20H23NO3 |
| Molecular Weight | 325.40 |
| SMILES | OC[C@@H](C1=CC=C(C=C1)OCC)NC([C@@H]2[C@@H](C3=CC=CC=C3)C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.