R1498 is a multi-target kinase inhibitor primarily affecting Aurora kinases and VEGFR2, associated with tumorigenesis. This compound exhibits notable anti-angiogenic and anti-proliferative properties, demonstrating moderate in vitro growth inhibition across various tumor cell lines with IC50 values in the micromolar range. In vivo studies reveal that R1498 surpasses sorafenib in anti-tumor efficacy within gastric cancer and hepatocellular carcinoma xenograft models, achieving tumor growth inhibition rates exceeding 80% along with substantial tumor shrinkage in select models. Additionally, R1498 effectively inhibits Aurora A activity and reduces tumor vascularization, underscoring its potential as a therapeutic candidate in oncology research.
R1498 is a multi-target kinase inhibitor primarily affecting Aurora kinases and VEGFR2, associated with tumorigenesis. This compound exhibits notable anti-angiogenic and anti-proliferative properties, demonstrating moderate in vitro growth inhibition across various tumor cell lines with IC50 values in the micromolar range. In vivo studies reveal that R1498 surpasses sorafenib in anti-tumor efficacy within gastric cancer and hepatocellular carcinoma xenograft models, achieving tumor growth inhibition rates exceeding 80% along with substantial tumor shrinkage in select models. Additionally, R1498 effectively inhibits Aurora A activity and reduces tumor vascularization, underscoring its potential as a therapeutic candidate in oncology research.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
