Fig. 1 · Structure
Documents & Downloads
Pfn1-IN-2
Cat. No.
A73231
CAS
919010-22-3
Endogenous Metabolite
Pfn1-IN-2 is a selective inhibitor of Profilin1 (Pfn1), designed to disrupt the interaction between Pfn1 and actin filaments. This compound effectively decreases the levels of filamentous (F) actin within cells, leading to diminished migration and proliferation of endothelial cells. Pfn1-IN-2 demonstrates significant inhibition of endothelial cell angiogenic capabilities in both in vitro and in vivo research settings, making it a valuable tool for studies in angiogenesis and cellular dynamics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 919010-22-3 |
| Applications | Endogenous Metabolite |
| Formula | C18H13N7O2 |
| Molecular Weight | 359.34 |
| SMILES | O=C1NN=C(C2=C1NC3=NN=NN3C2C4=CC=CC(O)=C4)C5=CC=CC=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.