Catalog No.
Product Name
Application
Product Information
Citations
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Anti-Inflammatory Agent
Andrograpanin is a bioactive compound derived from Andrographis paniculata, acting primarily as an anti-inflammatory agent. This molecule demonstrates significant anti-inflammatory and anti-infectious properties, making it a valuable tool for research in inflammatory diseases and infections. Its mechanism of action enables the modulation of inflammatory pathways, providing insight for therapeutic development in related conditions. -
Anti-inflammatory/Anti-fibrotic Agent
GDC-3280 is an orally active anti-inflammatory and anti-fibrotic agent that operates primarily through the inhibition of the ASK1-p38 MAPK pathway. It effectively mitigates the inflammatory and fibrotic responses associated with silicosis and influences macrophage polarization. GDC-3280 is a valuable tool for research aimed at understanding and developing therapeutic strategies for inflammatory and fibrotic diseases. -
WNT7A Inhibitor/Photosensitizer
WNT7A-IN-1 is a WNT7A inhibitor that disrupts the interaction between WNT7A and its receptor FZD5, leading to the upregulation of MHC-I expression. This compound enhances the expression of MHC-I and phosphorylated p65 while decreasing the levels of active β-catenin. Additionally, WNT7A-IN-1 serves as a photosensitizer in the green spectral region, making it valuable for research in cancer immunotherapy and photodynamic therapy applications. -
COX-2 Inhibitor
APHS is a selective and covalent inhibitor of cyclooxygenase-2 (COX-2) that exerts neuroprotective effects. By acetylating serine 516 in the active site of COX-2, APHS effectively inhibits prostaglandin production, which is often upregulated in colorectal cancer. In addition to its role as a COX-2 inhibitor, APHS also co-inhibits the WNT signaling pathway, contributing to its anti-tumor mechanisms. This compound is valuable for research into cancer biology and neuroprotection. -
5-LO/COX-2/DPP-4 Inhibitor
Timosaponin A1 is a natural steroidal saponin that acts as an inhibitor of 5-lipoxygenase (5-LO), cyclooxygenase-2 (COX-2), and dipeptidyl peptidase 4 (DPP-4), with IC50 values of 3.29 µM, 36.43 µM, and 33.25 µM, respectively. This compound exhibits anti-inflammatory properties and is relevant for research on conditions such as asthma and diabetes. Its inhibitory effects on key enzymes involved in inflammatory pathways make it a valuable tool for exploring therapeutic strategies in related biological studies. -
Arginase Inhibitor
nor-NOHA monoacetate is a selective and reversible inhibitor of arginase. It induces apoptosis in cells expressing arginase 2 under hypoxic conditions and demonstrates anti-leukemic activity. This compound is valuable for investigating endothelial dysfunction, immunosuppression, and metabolic processes in various biological contexts. -
Arginase Inhibitor
ABH hydrochloride is a potent arginase inhibitor with a Ki value of 8.5 nM. This compound enhances nitric oxide production and downregulates inflammatory mediators, including ICAM-1, VCAM-1, and MCP-1. ABH hydrochloride is utilized in research focused on erectile dysfunction, lung protection, wound healing, blood pressure regulation, and vascular fibrosis. Its dual role in promoting vasodilation and reducing inflammation makes it a valuable reagent for studying cardiovascular and inflammatory diseases. -
Arginase Inhibitor
OATD-02 is a competitive, reversible, noncovalent inhibitor that targets arginase 1 and 2. It exhibits slow offset kinetics with IC50 values of 20 nM for human arginase 1, 39 nM for human arginase 2, 39 nM for mouse arginase 1, and 28 nM for rat arginase 1. OATD-02 effectively disrupts tumor immunosuppression mediated by arginases, making it a valuable tool for research in melanoma and other cancer immunotherapy studies. -
Arginase Inhibitor
ARG1-IN-1 is a potent arginase inhibitor with an IC50 value of 29 nM. This compound effectively inhibits serum arginase activity, leading to increased levels of arginine in various mouse tumor models. ARG1-IN-1 is particularly useful for research applications focused on tumor biology and arginine metabolism in cancer. -
Arginase Inhibitor
NED-3238 is a potent inhibitor of arginase I and II, exhibiting IC50 values of 1.3 nM and 8.1 nM, respectively. This compound is valuable in research focused on metabolic regulation and immune modulation, facilitating studies related to cancer, cardiovascular diseases, and inflammation. Its high specificity and potency make it a suitable tool for investigating arginine metabolism and its implications in various biological processes. -
Arginase Inhibitor
(-)-3-O-Acetylcatechin is an arginase inhibitor that demonstrates significant activity against Leishmania amazonensis, with an IC50 value of 3.7 μM. This compound serves as a valuable tool for investigating leishmaniasis and studying arginase-related metabolic pathways in parasitic infections. Its application in biochemical research may contribute to the development of therapeutic strategies for managing leishmaniasis. -
Arginase Inhibitor
BEC is a competitive inhibitor of the binuclear manganese metalloenzyme arginase, functioning as an arginine analogue with slow-binding characteristics. This compound promotes the increased availability of arginine for nitric oxide synthase, thereby facilitating nitric oxide-dependent smooth muscle relaxation in the corpus cavernosum. As a result, BEC is significant in studies related to penile erection and vascular health. -
Arginase Inhibitor
NG-Hydroxy-L-arginine acetate is a selective arginase inhibitor that participates in modulating the nitric oxide pathway. By interfering with the conversion of arginine to citrulline, it facilitates increased nitric oxide production via nitric oxide synthase. This compound is valuable in research related to cardiovascular health, neurobiology, and inflammation, where nitric oxide signaling plays a critical role. -
Antibiotic Agent
Cloxacillin sodium is a β-lactam antibiotic and a potent β-lactamase inhibitor with an IC50 of 0.04 µM. It exhibits significant antibacterial activity, particularly against Staphylococcus aureus, and can effectively attenuate the S. aureus-induced inflammatory response by inhibiting the activation of MAPK, NF-κB, and NLRP3-related proteins. This compound is relevant for research in antimicrobial resistance and inflammation pathways. -
Anti-inflammatory/Antimicrobial Agent
Myricetin 3-O-glucoside, a flavonol derived from Tibouchina paratropica and Hakmeitau beans, primarily functions as an anti-inflammatory and antimicrobial agent. This compound demonstrates notable anti-Leishmanial activity, making it a valuable tool for studying inflammatory pathways and infectious diseases in research. Its diverse biological properties contribute to investigations in pharmacology and natural product chemistry. -
Antiviral/Anti-inflammatory Agent
Retusin, also known as Quercetin-3,3',4',7-tetramethylether, is a natural compound derived from the leaves of Talinum triangulare. It exhibits antiviral and anti-inflammatory properties, making it a valuable reagent for research into viral infections and inflammatory conditions. This compound’s dual activity supports investigations aimed at elucidating the mechanisms underlying viral pathogenesis and the inflammatory response. -
Anti-inflammatory Agent
Morelloflavone is an anti-inflammatory agent that exhibits significant antioxidative and antiviral properties. This compound has been shown to modulate inflammatory pathways, making it valuable for research into inflammatory diseases and potential therapeutic applications. Its diverse biological activities make Morelloflavone a relevant candidate for studies focused on oxidative stress and inflammation-related mechanisms. -
COX-2 Inhibitor
Thymohydroquinone is a selective inhibitor of cyclooxygenase-2 (COX-2) with noted anti-SARS-CoV-2 activity. It exhibits cytotoxic properties, antiproliferative effects, and the ability to suppress tumor growth in various cancer models. This compound is applicable in research focused on squamous cell carcinoma, fibrosarcoma, and the pathogenesis and treatment of COVID-19 caused by SARS-CoV-2. -
HPV Epitope Peptides Fragment
Human Papillomavirus (HPV) E7 protein (49-57) is a fragment of the E7 protein, specifically the epitope spanning amino acid residues 49 to 57, which is restricted by the H-2d MHC class I molecule. This peptide is vital for studying HPV-induced tumorigenesis and immune response mechanisms. It is commonly utilized in research applications focusing on HPV vaccination, T cell recognition, and the understanding of viral oncogenesis. -
Antiviral/Anti-Inflammatory Glycoprotein
Lactoferrin from Bovine Milk is a multifunctional iron-binding glycoprotein that exhibits antiviral and anti-inflammatory properties. Released by neutrophils, it plays a crucial role in inhibiting microbial and viral adhesion, as well as entry into host cells. This compound is also known to prevent cell adhesion and growth, contributing to its potential anti-cancer and immunomodulatory effects. Lactoferrin is widely applied in research focused on immune response modulation and pathogen resistance. -
Anti-inflammatory Agent
Astin C is a cyclopeptide derived from Aster tataricus that acts as an anti-inflammatory agent. It specifically inhibits the cGAS-STING signaling pathway, preventing the recruitment of IRF3 to the STING signalosome, thereby modulating the innate inflammatory response. Astin C is valuable for research into autoimmune diseases and cancer, making it a key reagent for studying inflammation-related mechanisms. -
iNOS Inhibitor
S-Methylisothiourea sulfate serves as a potent, selective, and competitive inhibitor of inducible nitric oxide synthase (iNOS). This compound has demonstrated significant biological activity in reducing nitric oxide production and exhibits protective effects in rodent models of septic shock. Its role in modulating iNOS activity makes it a valuable reagent for research focused on inflammation and immune response mechanisms. -
Anti-inflammatory/Antiinfection Agent
Forsyshiyanine A is a triterpenoid alkaloid known for its anti-inflammatory and antiviral properties. It effectively inhibits the release of β-glucuronidase from rat polymorphonuclear leukocytes, thereby demonstrating notable anti-inflammatory activity. Forsyshiyanine A also exhibits antiviral efficacy, with an EC50 of 4.5 μM against respiratory syncytial virus (RSV) and an IC50 of 7.3 μM against influenza A virus (H1N1), reducing viral load through disruption of viral replication and entry. This compound is valuable for research in the fields of inflammation and infection. -
Bioactive Peptide
Influenza NP (311-325) is a bioactive peptide derived from the nucleoprotein (NP) of the influenza virus, acting as an MHC class II restricted epitope to stimulate host immune responses. This peptide is known for its ability to induce substantial interferon gamma (IFN-γ) production while avoiding activation of CD8 T cells in murine models. Its unique properties make Influenza NP (311-325) a valuable tool for research in immunology and vaccine development. -
Anti-Inflammatory Agent
Agathisflavone is a flavonoid compound primarily recognized for its anti-inflammatory properties. It exhibits a range of biological activities, including antioxidant, antiviral, antiparasitic, cytotoxic, neuroprotective, and hepatoprotective effects. Research indicates that Agathisflavone may enhance tissue repair processes, particularly in spinal cord injury models in rodents, making it a valuable reagent for studies in inflammation and regenerative medicine. -
Nonimmunosuppressive Cyclophilin Inhibitor
NIM258 is a potent nonimmunosuppressive cyclophilin inhibitor, specifically targeting cyclophilin A with a Kd of 1.2 nM. It exhibits significant anti-HCV activity, with an EC50 of 40 nM. This compound serves as a valuable tool for research into HCV infection and its associated pathways. -
CXCR4 Antagonist
Mavorixafor trihydrochloride is a potent and selective antagonist of the CXCR4 receptor, exhibiting an IC50 of 13 nM in inhibiting CXCR4 125I-SDF binding. This compound has demonstrated significant antiviral activity by inhibiting the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs, with IC50 values of 1 nM and 9 nM, respectively. Mavorixafor trihydrochloride is applicable in research studying WHIM syndrome and various CXCR4-related biological processes. -
CCR7 and CXCR2 Antagonist
Cosalane is a dual antagonist of the chemokine receptors CCR7 (IC50 = 2.43 μM) and CXCR2 (IC50 = 0.66 μM). This compound effectively inhibits HIV replication across a variety of strains, including HIV-1, HIV-2, Rauscher murine leukemia virus, as well as herpes simplex viruses HSV-1 and HSV-2, and human cytomegalovirus. Cosalane disrupts the interaction between gp120 and CD4, inhibiting signaling downstream of CCR7 in response to its ligands CCL19 and CCL21. Research applications include studies on HIV and the potential modulation of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. -
CCR5 Inhibitor
DAPTA is a synthetic peptide that acts as a selective inhibitor of the CCR5 receptor. By blocking CCR5, DAPTA interferes with viral entry into host cells, exhibiting significant anti-HIV activity. This compound is valuable for research in virology and the development of therapeutic strategies against HIV. -
CXCR4 Antagonist
TC14012 is a peptidomimetic antagonist targeting the chemokine receptor CXCR4, exhibiting a high level of selectivity with an IC50 of 19.3 nM. In addition, TC14012 acts as a potent agonist for CXCR7, demonstrating an EC50 of 350 nM in β-arrestin 2 recruitment assays. This compound is utilized in research focused on HIV and cancer therapy, showcasing its potential in modulating chemokine signaling pathways. -
CXCR4 Antagonist
FC131 TFA is a potent CXCR4 antagonist that effectively inhibits the binding of [125I]-SDF-1 to CXCR4, demonstrating an IC50 value of 4.5 nM. This compound exhibits significant anti-HIV activity, making it a valuable tool for research in HIV treatment and other CXCR4-related studies. Its ability to disrupt CXCR4 signaling can be explored in various biological contexts, including cancer metastasis and immune response regulation. -
CXCR4 Antagonist
AMD 3465 is a potent antagonist of the CXCR4 chemokine receptor. It effectively inhibits the binding of both the 12G5 monoclonal antibody and CXCL12AF647 to CXCR4, demonstrating IC50 values of 0.75 nM and 18 nM in SupT1 cells, respectively. Additionally, AMD 3465 significantly impedes the replication of X4-tropic HIV strains, with IC50 values ranging from 1 to 10 nM, while showing no activity against CCR5-using (R5) viruses. This compound is suitable for research applications focusing on HIV treatment and CXCR4-related signaling pathways. -
CCR5 Antagonist
Aplaviroc hydrochloride is a potent CCR5 antagonist targeting the CCR5 co-receptor. It demonstrates biological activity with IC50 values ranging from 0.1 to 0.4 nM against various HIV-1 strains, including HIV-1Ba-L, HIV-1JRFL, and HIV-1MOKW. This compound is valuable for research applications focused on HIV entry inhibition and the development of antiviral therapies. -
HIV-1 Nef Binder, IKZF1 Modulator
FC-14369 is a PROTAC degrader that selectively targets the HIV-1 Nef protein, exhibiting a DC50 value of 160 nM. By engaging both Nef and the Cereblon E3 ubiquitin ligase, FC-14369 facilitates the ubiquitination and subsequent proteasomal degradation of Nef, leading to the restoration of CD4 and MHC-I expression on the cell surface and effectively inhibiting HIV-1 replication. This compound is valuable for research focused on HIV infection and AIDS, advancing understanding of therapeutic strategies in viral infections. -
CXCR4 Antagonist
KRH-3955 hydrochloride is a potent CXCR4 antagonist that effectively inhibits the binding of SDF-1α to CXCR4 with an IC50 of 0.61 nM. This compound demonstrates strong selectivity and efficacy against X4 HIV-1, with an EC50 ranging from 0.3 to 1.0 nM. KRH-3955 hydrochloride is suitable for research applications focused on HIV-1 pathogenesis and CXCR4-related signaling pathways. -
CXCR4 Antagonist
FC131 is a potent antagonist of the CXCR4 chemokine receptor. It effectively inhibits the binding of [125I]-SDF-1 to CXCR4 with an IC50 value of 4.5 nM. Due to its mechanism of action, FC131 demonstrates significant anti-HIV activity, making it a valuable tool for research into HIV pathogenesis and potential therapeutic interventions. -
Stable Isotope
Plerixafor-d4 is a deuterated derivative of Plerixafor, a selective antagonist of the CXCR4 receptor with an IC50 of 44 nM. This compound serves as an immunostimulant and is known for its ability to mobilize hematopoietic stem cells (HSCs). Additionally, Plerixafor has demonstrated efficacy in inhibiting HIV-1 and HIV-2 replication, with an EC50 ranging from 1 to 10 nM. Plerixafor-d4 is useful in research applications requiring stable isotopes for tracking and quantification purposes. -
HIV-1 Entry Inhibitor
RPR103611 is a derivative of betulinic acid that functions as a potent HIV-1 entry inhibitor. It displays IC50 values of 80 nM for CCR5-tropic virus YU2, 0.27 nM for CXCR4-tropic virus NL4-3, and 0.17 nM for dual tropic virus 89.6. This compound is valuable for research focused on the mechanisms of HIV-1 entry and the development of antiviral therapies. -
CCR5 Antagonist
CCR5 antagonist 3 is a potent inhibitor of the CCR5 receptor, exhibiting an IC50 of 15.90 nM. This compound demonstrates broad-spectrum anti-HIV-1 activity, making it a valuable tool for research focused on HIV-1 infection mechanisms and therapeutic development. Its specificity for CCR5 enhances its potential utility in studying chemokine receptor modulation and viral entry inhibition in various biological contexts. -
CCR5 Antagonist
Ancriviroc is a small molecule CCR5 antagonist that demonstrates potent antiviral activity against various HIV-1 isolates that utilize CCR5 as an entry coreceptor, with IC50 values ranging from 0.4 to 9 nM. This compound effectively inhibits the replication of R5-utilizing HIV-1 strains in the SCID-hu Thy/Liv mice model of HIV-1 infection. Ancriviroc is a valuable tool for research focused on HIV infection and the exploration of therapeutic strategies targeting CCR5. -
CXCR4 Antagonist
CXCR4 antagonist 7 is a potent CXCR4 antagonist with an IC50 of 9.3 nM. It effectively inhibits CXCR4 receptor activity, making it a valuable tool in the investigation of HIV infection, inflammatory diseases, cancer, and WHIM syndrome. This compound provides essential insights into the roles of CXCR4 signaling in various pathological conditions. -
CCR5 Antagonist
INCB9471 is a potent and selective CCR5 antagonist that serves as a critical resource for HIV-1 research. This orally active compound effectively inhibits CCR5-mediated entry of HIV-1 into host cells, demonstrating significant anti-HIV-1 activity. Its targeted mechanism of action makes INCB9471 a valuable tool for studying HIV pathogenesis and developing therapeutic strategies against HIV infection. -
CCR5 Antagonist
Vicriviroc is a potent CCR5 antagonist with an IC50 of 10 nM. It effectively inhibits the release of MIP-1α and intracellular calcium levels induced by the ligand RANTES, with IC50 values of 0.91 nM and 16 nM, respectively. Vicriviroc is primarily utilized in research related to human immunodeficiency virus type 1 (HIV-1) infection and holds potential for cancer studies. -
CXCR Inhibitor
AMD 3329 octahydrobromide is a potent CXCR4 inhibitor that effectively reduces HIV-1 and HIV-2 viral replication. It demonstrates exceptional antiviral activity with EC50 values of 0.8 nM and 1.6 nM, surpassing the efficacy of related compounds. Additionally, AMD 3329 significantly obstructs the binding of specific CXCR4 monoclonal antibodies and inhibits SDF-1 alpha-induced Ca(2+) influx. This compound also disrupts virus-induced syncytium formation, with an EC50 of 12 nM, making it a valuable tool for HIV research and therapeutic development. -
Antibacterial Agent
Cloxacillin is an orally active antibacterial agent and β-lactamase inhibitor, exhibiting an IC50 of 0.04 µM. It effectively suppresses the inflammatory response induced by Staphylococcus aureus by inhibiting the activation of mitogen-activated protein kinases (MAPKs), nuclear factor kappa B (NF-κB), and proteins associated with the NLRP3 inflammasome. This compound is useful for research applications focused on bacterial infections and inflammatory processes. -
COX1/2 Inhibitor
Indomethacin sodium is a potent inhibitor of cyclooxygenase enzymes COX-1 and COX-2, exhibiting IC50 values of 18 nM and 26 nM, respectively. This compound demonstrates significant anticancer and anti-infective properties, making it valuable in various biological research applications. Indomethacin sodium is essential for investigating mechanisms related to cancer treatment, inflammation, and viral infections. -
Nrf2 Activator
Ginnalin A, a potent Nrf2 activator, demonstrates significant antiproliferative activity against HCT116, SW480, and SW620 cancer cell lines, with IC50 values of 24.8, 22.0, and 39.7 μM, respectively. This compound induces S phase arrest in cancer cells and activates the p62-Keap1-Nrf2 signaling pathway, leading to the upregulation of mRNA and protein expressions of key protective markers such as Nrf2, HO-1, and NQO1. Additionally, Ginnalin A promotes the translocation of Nrf2 from the cytoplasm to the nucleus, making it a valuable tool for research into colon cancer mechanisms and potential therapies. -
Keap1/S349-p-p62 Interaction Inhibitor
K67 is a selective inhibitor targeting the interaction between Keap1 and S349 phosphorylated p62, with an IC50 of 1.5 μM. This compound demonstrates a weaker inhibitory effect on the Keap1-Nrf2 interaction (IC50 of 6.2 μM) and functions by competitively binding to Keap1's binding site, disrupting the aberrant activation of the p62-dependent Nrf2 pathway. K67 has been shown to inhibit tumor cell proliferation and increase the sensitivity of hepatocellular carcinoma (HCC) cells to chemotherapeutic agents by restoring Keap1-mediated ubiquitination and subsequent degradation of Nrf2. This makes K67 a valuable tool for investigating therapeutic strategies in cancer research. -
Anti-Inflammatory Agent
Triptohypol C is a Tripterin derivative that functions as a potent anti-inflammatory agent by specifically targeting Nur77. It exhibits a Kd value of 0.87 μM, facilitating the modulation of inflammatory responses through enhanced interactions between Nur77 and TRAF2 as well as p62/SQSTM1. This compound is valuable for research applications focusing on inflammation and related signaling pathways. -
AUTAC Ligand
TSPO ligand-3 serves as a ligand for AUTAC2, which features a p-fluorobenzylguanine (FBnG) moiety alongside a synthetic FKBP ligand (SLF). This compound exhibits notable biological activity by significantly silencing FKBP12 in HeLa cells. Research applications include studying targeted protein degradation and investigating the mechanistic pathways of autophagy-related and intracellular degradation processes.
