Fig. 1 · Structure
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Necrosulfonamide-d4
Stable Isotope
Necrosulfonamide-d4 is a deuterium-labeled variant of Necrosulfonamide, a potent inhibitor of MLKL and Gasdermin D (GSDMD). This compound specifically targets the downstream oligomerization step of necroptosis and pyroptosis without affecting upstream signaling pathways. By attenuating the expression of pivotal kinases such as NLRP3 and caspase-1, Necrosulfonamide-d4 modulates inflammatory responses and activates the Nrf2 pathway, enhancing antioxidant enzyme activity. This reagent is valuable for research applications involving neurodegenerative diseases, inflammatory conditions, tissue damage, and programmed necrosis pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1795144-22-7 |
| Applications | Stable Isotope |
| Formula | C18H11D4N5O6S2 |
| Molecular Weight | 465.50 |
| SMILES | COC1=NC=CN=C1NS(=O)(C2=C([2H])C([2H])=C(C([2H])=C2[2H])NC(/C=C/C3=CC=C([N+]([O-])=O)S3)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.