Fig. 1 · Structure
Documents & Downloads
(E/Z)-Necrosulfonamide
Racemic Compound
(E/Z)-Necrosulfonamide is a racemic compound that inhibits MLKL and Gasdermin D (GSDMD), targeting distinct programmed necrosis pathways, specifically necroptosis and pyroptosis. This compound impedes the oligomerization process of downstream executors without interfering with upstream signaling activation. It has been shown to reduce the expression of key kinases such as NLRP3 and caspase-1, activate the Nrf2 pathway, and downregulate various inflammatory factors. Research applications include studies related to neurodegenerative diseases, tissue damage, ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis, and hair loss.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 432531-71-0 |
| Applications | Racemic Compound |
| Formula | C18H15N5O6S2 |
| Molecular Weight | 461.47 |
| SMILES | O=C(/C=C/C1=CC=C(S1)[N+]([O-])=O)NC2=CC=C(C=C2)S(=O)(NC3=NC=CN=C3OC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.