Homoeriodictyol is a flavanone metabolite of Eriocitrin that exhibits a range of biological activities. It enhances synaptic-related protein expression via NCOA4-mediated ferritin autophagy and offers potential cognitive benefits by improving memory impairment in mice through inhibition of the NLRP3 inflammasome. Additionally, Homoeriodictyol protects human endothelial cells against oxidative stress by activating the Nrf2 pathway and preventing mitochondrial dysfunction. Its anticancer properties are demonstrated through the inhibition of survival and migration in androgen-resistant prostate cancer cells, as well as its ability to induce apoptosis and enhance reactive oxygen species activity. Moreover, Homoeriodictyol displays antinociceptive effects in vivo.
Homoeriodictyol is a flavanone metabolite of Eriocitrin that exhibits a range of biological activities. It enhances synaptic-related protein expression via NCOA4-mediated ferritin autophagy and offers potential cognitive benefits by improving memory impairment in mice through inhibition of the NLRP3 inflammasome. Additionally, Homoeriodictyol protects human endothelial cells against oxidative stress by activating the Nrf2 pathway and preventing mitochondrial dysfunction. Its anticancer properties are demonstrated through the inhibition of survival and migration in androgen-resistant prostate cancer cells, as well as its ability to induce apoptosis and enhance reactive oxygen species activity. Moreover, Homoeriodictyol displays antinociceptive effects in vivo.
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