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NLRP3 modulator 8

NLRP3 modulator

NLRP3 Modulator 8 is a selective modulator targeting the NLRP3 inflammasome, exhibiting a DC50 of 9 nM for NEK7 degradation. It effectively inhibits caspase-1 activity and IL-1β release in macrophages, demonstrating dose-dependent effects upon NLRP3 activation. This compound is valuable for research into autoinflammatory and autoimmune diseases, such as multiple sclerosis and Alzheimer's disease, as well as cardiovascular and metabolic disorders, including pericarditis and Type 2 diabetes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	3069891-88-6
Applications	NLRP3 modulator
Formula	C₂₀H₁₉Cl₂FN₄O₃
Molecular Weight	453.29
SMILES	O=C1NC(C(CC1)C2=C(C=C(CNC(C(C)(C)C3=NC=C(C=N3)F)=O)C=C2Cl)Cl)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.