Fig. 1 · Structure
Documents & Downloads
Pomalidomide-5-C8-NH2 hydrochloride
CRBN Ligand
Pomalidomide-5-C8-NH2 hydrochloride is a CRBN ligand derived from Pomalidomide. This compound facilitates the recruitment of the cereblon (CRBN) protein, enabling the design of targeted protein degradation strategies. It can be conjugated with a suitable linker to create PROTACs, which are valuable tools in therapeutic applications for modulating protein levels in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2863635-03-2 |
| Applications | CRBN Ligand |
| Formula | C21H29ClN4O4 |
| Molecular Weight | 436.93 |
| SMILES | O=C1C(C=CC(NCCCCCCCCN)=C2)=C2C(N1C(CC3)C(NC3=O)=O)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.